Nutrients,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1500 - 1500
Published: May 16, 2024
As
the
population
ages,
incidence
of
age-related
neurodegenerative
diseases
is
rapidly
increasing,
and
novel
approaches
to
mitigate
this
soaring
prevalence
are
sorely
needed.
Recent
studies
have
highlighted
importance
gut
microbial
homeostasis
its
impact
on
brain
functions,
commonly
referred
as
gut–brain
axis,
in
maintaining
overall
health
wellbeing.
Nonetheless,
mechanisms
by
which
system
acts
remains
poorly
defined.
In
review,
we
will
explore
how
(poly)phenols,
a
class
natural
compounds
found
many
plant-based
foods
beverages,
can
modulate
thereby
promote
neural
health.
While
evidence
indicates
beneficial
role
(poly)phenol
consumption
part
balanced
diet,
human
scarce
mechanistic
insight
still
lacking.
regard,
make
case
that
dietary
(poly)phenols
should
be
further
explored
establish
their
therapeutic
efficacy
through
modulation
with
much
greater
emphasis
carefully
designed
interventions.
Developing
oral
drug
delivery
systems
is
promising
for
ulcerative
colitis
(UC).
However,
the
key
challenges,
including
formulation
degradation
under
harsh
gastric
conditions,
poor
targeting
efficiency,
and
limited
colonic
residence,
lead
to
therapeutic
efficacy
that
still
needs
be
tackled.
Effective
treatment
requires
a
safe,
efficacious,
enzyme-
pH-responsive,
biomucoadhesive
system
overcome
these
challenges.
Therefore,
we
have
developed
chitosan-armored
1,2-dimyristoyl-sn-glycero-3-phosphoglycerol
(DMPG)
nanoliposomes
amalgamated
with
synthesized
beta-sitosterol-sinapic
acid
(Be-S)
conjugate,
further
encapsulated
3,4-methylenedioxy-β-nitrostyrene
(MNS)
as
NLRP3
inhibitor,
termed
C@MN@DMBe-S,
limitation
of
free
MNS
sinapic
acid.
Formulated
by
thin-film
hydration
method
processed
through
extrusion,
unilamellar
liposomes
demonstrated
structural
stability
mucoadhesive
properties
due
chitosan
coating.
This
configuration
protected
from
acidic
environment
allowed
retention
in
inflamed
colon
48
h.
The
enzyme-responsive
C@MN@DMBe-S
nanoliposome
releases
at
site
via
esterase
activity,
providing
sustained
controlled
release
MNS.
synergistic
action
delivers
antioxidant
anti-inflammatory
effects
while
influencing
gut
microbiota
composition
releasing
short-chain
fatty
acids.
Moreover,
investigations
revealed
exhibited
superior
compared
when
administered
orally.
effectively
downregulated
NF-κB,
NLRP3,
Caspase-1,
IL-1β
expression
upregulating
MUC5AC
expression,
indicating
enhanced
protective
thereby
promoting
mucosal
healing.
In
addition,
was
found
regulate
immune
cell
downregulate
neutrophil
infiltration.
armor-
strategy
elucidates
impact
nanomedicines
on
mitigating
UC
an
effective
treatment.
Small,
Journal Year:
2024,
Volume and Issue:
20(46)
Published: Aug. 6, 2024
Abstract
Diabetic
wounds
are
characterized
by
the
disruption
and
cessation
of
essential
healing
stages,
which
include
hemostasis,
inflammation,
proliferation,
remodeling.
However,
traditional
treatments
for
diabetic
concentrate
on
individual
stages
process.
Herein,
this
study
utilizes
mask‐mediated
sequential
polymerization
varied
cross‐linking
techniques
to
develop
dual‐modular
microneedles
(MNs)
with
fast‐
slow‐module,
exhibiting
varying
degradation
rates
tailored
full
spectrum
wound
healing.
First,
MNs
incorporating
calcium
ions
dopamine
synergistically
promote
rapid
hemostasis.
Second,
fast‐module
physically
cross‐linked
rapidly
D‐mannose/dopamine‐enhanced
tripolyphosphate‐quaternized
chitosan
(mDTC)
nanoparticles
(NPs)
loaded
microRNA‐147
(miRNA‐147)
manage
inflammation
oxidative
stress
in
wounds.
Additionally,
these
NPs
enhances
their
internalization
safeguards
miRNA‐147
from
RNase
degradation.
Finally,
slow‐module
chemically
facilitate
continuous
release
deferoxamine
(DFO)
dopamine,
accelerating
angiogenesis
tissue
regeneration
during
proliferation
remodeling
stages.
Manganese/dopamine‐enhanced
peroxide
within
initiate
a
blast‐like
generation
oxygen
bubbles,
not
only
enhancing
delivery
miRNA‐mDTC
DFO
but
also
alleviating
hypoxia.
Consequently,
instrumental
promoting
complete
through
all
Biomaterials Science,
Journal Year:
2024,
Volume and Issue:
12(9), P. 2282 - 2291
Published: Jan. 1, 2024
Polyphenolic
antibacterial
bio-adhesives
were
synthesised
via
polyphenols
and
acid
anhydrides
without
solvent
or
catalyst.
Upon
heating,
these
adhesives
could
induce
strong
adhesion
onto
various
substrates,
while
demonstrating
excellent
antibacterial,
antiinfection
biodegradability
properties.
