Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Май 22, 2024
Recent
years
have
witnessed
a
surge
in
the
application
of
microrobots
within
medical
sector,
with
hydrogel
standing
out
due
to
their
distinctive
advantages.
These
microrobots,
characterized
by
exceptional
biocompatibility,
adjustable
physico-mechanical
attributes,
and
acute
sensitivity
biological
environments,
emerged
as
pivotal
tools
advancing
applications
such
targeted
drug
delivery,
wound
healing
enhancement,
bio-imaging,
precise
surgical
interventions.
The
capability
navigate
perform
tasks
complex
systems
significantly
enhances
precision,
efficiency,
safety
therapeutic
procedures.
Firstly,
this
paper
delves
into
material
classification
properties
compares
advantages
different
materials.
Furthermore,
it
offers
comprehensive
review
principal
categories
recent
innovations
synthesis,
actuation
mechanisms,
biomedical
hydrogel-based
microrobots.
Finally,
manuscript
identifies
prevailing
obstacles
future
directions
microrobot
research,
aiming
furnish
insights
that
could
propel
advancements
field.
Cyborg and Bionic Systems,
Год журнала:
2024,
Номер
5
Опубликована: Янв. 1, 2024
Untethered
and
self-transformable
miniature
robots
are
capable
of
performing
reconfigurable
deformation
on-demand
locomotion,
which
aid
the
traversal
toward
various
lumens,
bring
revolutionary
changes
for
targeted
delivery
in
gastrointestinal
(GI)
tract.
However,
viscous
non-Newtonian
liquid
environment
plicae
gastricae
obstacles
severely
hamper
high-precision
actuation
payload
delivery.
Here,
we
developed
a
low-friction
soft
robot
by
assembly
densely
arranged
cone
structures
grafting
hydrophobic
monolayers.
The
magnetic
orientation
encoded
can
move
multiple
modes,
with
substantially
reduced
drag,
terrain
adaptability,
improved
motion
velocity
across
liquids.
Notably,
stiffness
be
reversibly
controlled
magnetically
induced
hardening,
enabling
on-site
scratching
destruction
antibiotic-ineradicable
polymeric
matrix
biofilms
low-frequency
field.
Furthermore,
magnetocaloric
effect
utilized
to
eradicate
bacteria
under
high-frequency
alternating
To
verify
potential
applications
inside
body,
clinical
imaging-guided
platforms
were
vision-based
control
robots.
show
their
high
perform
bacterial
infection
therapy
lumens
body.
Catheters
navigating
through
complex
vessels,
such
as
sharp
turns
or
multiple
U-turns,
remain
challenging
for
vascular
embolization.
Here,
we
propose
a
novel
multistage
embolization
strategy
hard-to-reach
vessels
that
releases
untethered
swimming
shape-memory
magnetic
microrobots
(SMMs)
from
the
prior
catheter
to
vessel
bifurcation.
SMMs,
made
of
organo-gel
with
particles,
ensure
biocompatibility,
radiopacity,
thrombosis,
and
fast
thermal
responses.
An
SMM
is
initially
linear
shape
0.5-mm
diameter
at
20
°C
inserted
in
catheter.
It
transforms
into
predetermined
helix
within
2
s
38
blood
temperature
after
being
pushed
out
blood.
SMMs
enable
agile
confined
tortuous
can
swim
upstream
using
helical
propulsion
rotating
fields.
Moreover,
validated
this
living
rabbits,
completing
100-cm
travel
renal
artery
min.
After
4
weeks,
maintained
embolic
position,
kidney
volume
decreased
by
36%.
ACS Nano,
Год журнала:
2023,
Номер
17(14), С. 13081 - 13109
Опубликована: Июль 13, 2023
Untethered
small-scale
machines
(USSMs)
that
can
actively
adjust
their
motion,
deformation,
and
collective
states
in
response
to
external
stimuli
have
gained
enormous
interest
various
manipulation,
sensing,
biomedical
applications.
Because
they
be
efficiently
operated
confined
tortuous
environments,
USSMs
are
capable
of
conducting
wireless
microrobotic
manipulation
tasks
tethered
find
hard
achieve.
Over
the
past
decade
development,
significant
research
progress
has
been
achieved
designing
USSM-based
strategies,
which
enabled
by
investigating
machine-object,
machine-environment,
machine-machine
interactions.
This
review
summarizes
latest
developments
for
utilizing
individual
machines,
coordinating
multiple
inducing
behaviors.
Providing
recent
studies
relevant
applications
areas,
we
also
discuss
challenges
future
perspectives
facing
USSMs-based
intelligent
systems
achieve
complex
environments
with
imaging-guided
processes
increasing
autonomy
levels.
Nano-Micro Letters,
Год журнала:
2023,
Номер
16(1)
Опубликована: Ноя. 30, 2023
Abstract
Untethered
micro/nanorobots
that
can
wirelessly
control
their
motion
and
deformation
state
have
gained
enormous
interest
in
remote
sensing
applications
due
to
unique
characteristics
various
media
diverse
functionalities.
Researchers
are
developing
as
innovative
tools
improve
performance
miniaturize
systems,
enabling
situ
detection
of
substances
traditional
methods
struggle
achieve.
Over
the
past
decade
development,
significant
research
progress
has
been
made
designing
strategies
based
on
micro/nanorobots,
employing
coordinated
approaches.
This
review
summarizes
latest
developments
for
by
utilizing
self-generated
signals
robots,
robot
behavior,
microrobotic
manipulation,
robot-environment
interactions.
Providing
recent
studies
relevant
sensing,
we
also
discuss
challenges
future
perspectives
facing
micro/nanorobots-based
intelligent
platforms
achieve
complex
environments,
translating
lab
achievements
into
widespread
real
applications.
Advanced Materials,
Год журнала:
2023,
Номер
36(9)
Опубликована: Окт. 30, 2023
Nanorobots
capable
of
active
movement
are
an
exciting
technology
for
targeted
therapeutic
intervention.
However,
the
extensive
motion
range
and
hindrance
blood-brain
barrier
impeded
their
clinical
translation
in
glioblastoma
therapy.
Here,
a
marsupial
robotic
system
constructed
by
integrating
chemical/magnetic
hybrid
nanorobots
(child
robots)
with
miniature
magnetic
continuum
robot
(mother
robot)
intracranial
cross-scale
targeting
drug
delivery
is
reported.
For
primary
on
macroscale,
enters
cranial
cavity
through
minimally
invasive
channel
(e.g.,
Ommaya
device)
skull
transports
to
pathogenic
regions.
Upon
circumventing
barrier,
released
perform
secondary
microscale
further
enhance
spatial
resolution
delivery.
In
vitro
experiments
against
cells
derived
from
different
patients
conducted
personalized
treatment
guidance.
The
operation
feasibility
within
organisms
shown
ex
vivo
swine
brain
experiments.
biosafety
suggested
Owing
hierarchical
method,
rate,
accuracy,
efficacy
have
improved
greatly.
offers
novel
local
strategy
constitutes
key
milestone
development
platforms.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 23, 2024
Swarm
behaviors
are
common
in
nature,
where
individual
organisms
collaborate
via
perception,
communication,
and
adaptation.
Emulating
these
dynamics,
large
groups
of
active
agents
can
self-organize
through
localized
interactions,
giving
rise
to
complex
swarm
behaviors,
which
exhibit
potential
for
applications
across
various
domains.
This
review
presents
a
comprehensive
summary
perspective
synthetic
swarms,
bridge
the
gap
between
microscale
swarms.
It
is
begun
by
examining
agents,
fundamental
units
understand
origins
their
motility
functionality
presence
external
stimuli.
Then
inter-agent
communications
agent-environment
that
contribute
generation
summarized.
Furthermore,
reported
date
emergence
machine
intelligence
within
reviewed.
Eventually,
enabled
distinct
swarms
By
discussing
emergent
insights
offered
into
design
deployment
autonomous
real-world
applications.
Lab on a Chip,
Год журнала:
2024,
Номер
24(4), С. 832 - 842
Опубликована: Янв. 1, 2024
A
high-performance
pure-nickel
magnetically-actuated
microrobot
(Ni-MAR)
is
printed
by
a
‘femtosecond
laser
polymerization
+
sintering’
method
with
great
potential
applications
in
controlled
locomotion
fast-flowing
blood
and
massive
drugs
delivery.
