Journal of Inorganic Biochemistry,
Год журнала:
2024,
Номер
254, С. 112505 - 112505
Опубликована: Фев. 15, 2024
Platinum-based
anticancer
drugs,
while
potent,
are
associated
with
numerous
and
severe
side
effects.
Hyperthermia
therapy
is
an
effective
adjuvant
in
treatment,
however,
clinically
used
platinum
drugs
have
not
been
optimised
for
combination
hyperthermia.
The
derivatisation
of
existing
appropriately
chosen
thermoresponsive
moieties
results
being
activated
only
at
the
heated
site.
Perfluorinated
chains
varying
lengths
were
installed
on
carboplatin,
a
approved
drug,
leading
to
successful
synthesis
series
mono-
di-
substituted
platinum(IV)
carboplatin
prodrugs.
Some
these
complexes
display
relevant
thermosensitivity
ovarian
cancer
cell
lines,
i.e.,
inactive
37
°C
having
comparable
activity
under
mild
hyperthermia
(42
°C).
Nuclear
magnetic
resonance
spectroscopy
mass
spectrometry
indicated
that
likely
active
platinum(II)
agent
upon
reduction
cyclic
voltammetry
revealed
length
fluorinated
alkyl
chain
has
strong
influence
rate
formation,
regulating
subsequent
cytotoxicity.
Chemical Reviews,
Год журнала:
2024,
Номер
124(13), С. 8307 - 8472
Опубликована: Июнь 26, 2024
Due
to
the
intrinsic
non-invasive
nature,
cost-effectiveness,
high
safety,
and
real-time
capabilities,
besides
diagnostic
imaging,
ultrasound
as
a
typical
mechanical
wave
has
been
extensively
developed
physical
tool
for
versatile
biomedical
applications.
Especially,
prosperity
of
nanotechnology
nanomedicine
invigorates
landscape
ultrasound-based
medicine.
The
unprecedented
surge
in
research
enthusiasm
dedicated
efforts
have
led
mass
multifunctional
micro-/nanosystems
being
applied
biomedicine,
facilitating
precise
diagnosis,
effective
treatment,
personalized
theranostics.
deployment
applications
is
rooted
profound
understanding
relationship
among
composition,
structure,
property,
bioactivity,
application,
performance.
In
this
comprehensive
review,
we
elaborate
on
general
principles
regarding
design,
synthesis,
functionalization,
optimization
abundant
particular,
recent
advancements
imaging
are
meticulously
summarized.
Furthermore,
systematically
elucidate
state-of-the-art
studies
concerning
progress
therapeutic
targeting
various
pathological
abnormalities
including
cancer,
bacterial
infection,
brain
diseases,
cardiovascular
metabolic
diseases.
Finally,
conclude
provide
an
outlook
field
with
in-depth
discussion
challenges
faced
future
developments
further
extensive
clinical
translation
application.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
Coordination Chemistry Reviews,
Год журнала:
2023,
Номер
497, С. 215439 - 215439
Опубликована: Сен. 18, 2023
Oxaliplatin
was
the
third
Pt-based
anticancer
drug
to
be
clinically
used
worldwide.
It
exhibits
a
broad
spectrum
of
activity
and
first
approved
for
treatment
colorectal
cancer.
Significantly
oxaliplatin
can
induce
immunogenic
cell
death
cytotoxicity
via
nucleolar
stress
in
addition
established
Pt(II)
DNA
damage
responses.
In
this
review,
we
describe
oxaliplatin's
discovery,
its
properties
how
it
is
administered
as
an
agent.
We
provide
account
current
understanding
mechanisms
action
resistance,
which
essential
background
information
any
medicinal
inorganic
chemist
interested
designing
developing
derivatives,
or
indeed
novel
classes
drugs.
Furthermore
key
examples
recent
strategies
employed
enhance
ability
overcome
improve
specificity
cancer
cells
Pt
accumulation
at
sites
tumors.
doing
so
cover
(i)
(ii)
functionalised
Pt(IV)
(iii)
photoactivatable
(iv)
probes
(v)
delivery
platforms
accumulation.
certainly
unique
member
class
chemotherapeutics.
Continued
research
required
our
important
develop
new
more
effective
selectively
delivered
analogues
that
resistance.
Nano Letters,
Год журнала:
2024,
Номер
24(28), С. 8741 - 8751
Опубликована: Июль 2, 2024
The
degradation
of
oncoproteins
mediated
by
proteolysis-targeting
chimera
(PROTAC)
has
emerged
as
a
potent
strategy
in
cancer
therapy.
However,
the
clinical
application
PROTACs
is
hampered
challenges
such
poor
water
solubility
and
off-target
adverse
effects.
Herein,
we
present
an
ultrasound
(US)-activatable
PROTAC
prodrug
termed
NP
Abstract
Cellular
senescence,
a
vulnerable
state
of
growth
arrest,
has
been
regarded
as
potential
strategy
to
weaken
the
resistance
tumor
cells,
leading
dramatic
improvements
in
treatment
efficacy.
However,
selective
and
efficient
for
inducing
local
cellular
senescence
not
yet
reported.
Herein,
piezoelectric
catalysis
is
utilized
reduce
intracellular
NAD
+
NADH
cell
first
time.
In
detail,
biocompatible
nanomedicine
(BTO/Rh‐D@M)
constructed
by
wrapping
BaTiO
3
/(Cp
*
RhCl
2
)
(BTO/Rh)
doxorubicin
(DOX)
homologous
cytomembrane
with
target.
After
tumors
are
stimulated
ultrasound,
negative
positive
charges
generated
on
BTO/Rh
catalysis,
which
oxidize
H
O
reactive
oxygen
species
(ROS)
mitochondrial
damage.
Thus,
therapeutic
efficacy
immunogenic
death‐induced
chemo‐immunotherapy
boosted
combining
DOX,
ROS.
The
results
indicate
that
23.9%
catalysis‐treated
cells
senesced,
solid
mice
disappeared
completely
after
therapy.
Collectively,
this
study
highlights
novel
realize
utilizing
significance
improve
Journal of the American Chemical Society,
Год журнала:
2024,
Номер
146(37), С. 25764 - 25779
Опубликована: Авг. 7, 2024
Photoresponsive
ruthenium(II)
complexes
have
recently
emerged
as
a
promising
tool
for
synergistic
photodynamic
therapy
and
chemotherapy
in
oncology,
well
antimicrobial
applications.
However,
the
limited
penetration
power
of
photons
prevents
treatment
deep-seated
lesions.
In
this
study,
we
introduce
sonoresponsive
ruthenium
complex
capable
generating
superoxide
anion
(O2•–)
via
type
I
process
initiating
ligand
fracture
upon
ultrasound
triggering.
Attaching
hydroxyflavone
(HF)
an
"electron
reservoir"
to
octahedral-polypyridyl-ruthenium
resulted
decreased
highest
occupied
molecular
orbital
(HOMO)–lowest
unoccupied
(LUMO)
energy
gaps
triplet-state
metal
charge
transfer
(3MLCT)
state
(0.89
eV).
This
modification
enhanced
generation
O2•–
under
therapeutic
irradiation
at
frequency
1
MHz.
The
produced
rapidly
induced
intramolecular
cascade
reaction
HF
fracture.
As
proof-of-concept,
engineered
Ru
into
metallopolymer
platform
(PolyRuHF),
which
could
be
activated
by
low-power
(1.5
W
cm–2,
1.0
MHz,
50%
duty
cycle)
within
centimeter
range
tissue.
activation
led
release
cytotoxic
complexes.
Consequently,
PolyRuHF
cellular
apoptosis
ferroptosis
causing
mitochondrial
dysfunction
excessive
toxic
lipid
peroxidation.
Furthermore,
effectively
inhibited
subcutaneous
orthotopic
breast
tumors
prevented
lung
metastasis
downregulating
metastasis-related
proteins
mice.
study
introduces
first
sonodynamic
therapy/sonoactivated
chemotherapy,
offering
new
avenues
deep
tumor
treatment.
Advanced Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 17, 2024
Abstract
Nanotheranostics,
which
integrate
diagnostic
and
therapeutic
functionalities,
offer
significant
potential
for
tumor
treatment.
However,
current
nanotheranostic
systems
typically
involve
multiple
molecules,
each
providing
a
singular
or
function,
leading
to
challenges
such
as
complex
structural
composition,
poor
targeting
efficiency,
lack
of
spatiotemporal
control,
dependence
on
single
modality.
This
study
introduces
NP
RBOXA
,
nanoparticle
functionalized
with
surface‐bound
cRGD
targeted
delivery
α
v
β
3
/α
5
receptors
cells,
achieving
theranostic
integration
by
sequentially
switching
its
irradiation
modes.
Under
808
nm
laser
irradiation,
emits
NIR‐II
fluorescence,
aids
in
identifying
the
nanoparticle's
location
fluorescence
intensity,
thereby
determining
optimal
treatment
window.
Following
this,
mode
switches
ultrasound
at
Ultrasound
induces
generate
reactive
oxygen
species,
promoting
reduction
OXA‐IV
OXA‐II,
turn
triggers
immunogenic
cell
death.
mechanism
enables
combination
sonodynamic
therapy,
chemotherapy,
immunotherapy
The
versatile
design
holds
promise
advancing
precision
oncology
through
enhanced
efficacy
real‐time
imaging
guidance.
