bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 22, 2023
Abstract
Sleep
and
feeding
patterns
lack
strong
daily
rhythms
during
early
life.
As
diurnal
animals
mature,
is
consolidated
to
the
day
sleep
night.
In
Drosophila
,
circadian
are
initiated
with
formation
of
a
circuit
connecting
central
clock
arousal
output
neurons;
emergence
also
enables
long-term
memory
(LTM).
However,
cues
that
trigger
development
this
clock-arousal
unknown.
Here,
we
identify
role
for
nutritional
status
in
driving
sleep-wake
rhythm
larvae.
We
find
2
nd
instar
larval
period
(L2),
spread
across
day;
these
behaviors
become
organized
into
by
3
rd
stage
(L3).
Forcing
mature
(L3)
adopt
immature
(L2)
strategies
disrupts
ability
exhibit
LTM.
addition,
(DN1a)-arousal
(Dh44)
itself
influenced
environment.
Finally,
demonstrate
Dh44
neurons
act
through
glucose
metabolic
genes
drive
onset
rhythms.
Together,
our
data
suggest
changes
energetic
demands
developing
organisms
sleep-circadian
circuits
behaviors.
Sleep
and
feeding
patterns
lack
strong
daily
rhythms
during
early
life.
As
diurnal
animals
mature,
is
consolidated
to
the
day
sleep
night.
In
Drosophila,
circadian
are
initiated
with
formation
of
a
circuit
connecting
central
clock
arousal
output
neurons;
emergence
also
enables
long-term
memory
(LTM).
However,
cues
that
trigger
development
this
clock-arousal
unknown.
Here,
we
identify
role
for
nutritional
status
in
driving
sleep-wake
rhythm
Drosophila
larvae.
We
find
2nd
instar
larval
period
(L2),
spread
across
day;
these
behaviors
become
organized
into
by
3rd
stage
(L3).
Forcing
mature
(L3)
adopt
immature
(L2)
strategies
disrupts
ability
exhibit
LTM.
addition,
(DN1a)-arousal
(Dh44)
itself
influenced
environment.
Finally,
demonstrate
Dh44
neurons
act
through
glucose
metabolic
genes
drive
onset
rhythms.
Together,
our
data
suggest
changes
energetic
demands
developing
organisms
sleep-circadian
circuits
behaviors.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 22, 2023
Abstract
Sleep
and
feeding
patterns
lack
strong
daily
rhythms
during
early
life.
As
diurnal
animals
mature,
is
consolidated
to
the
day
sleep
night.
In
Drosophila
,
circadian
are
initiated
with
formation
of
a
circuit
connecting
central
clock
arousal
output
neurons;
emergence
also
enables
long-term
memory
(LTM).
However,
cues
that
trigger
development
this
clock-arousal
unknown.
Here,
we
identify
role
for
nutritional
status
in
driving
sleep-wake
rhythm
larvae.
We
find
2
nd
instar
larval
period
(L2),
spread
across
day;
these
behaviors
become
organized
into
by
3
rd
stage
(L3).
Forcing
mature
(L3)
adopt
immature
(L2)
strategies
disrupts
ability
exhibit
LTM.
addition,
(DN1a)-arousal
(Dh44)
itself
influenced
environment.
Finally,
demonstrate
Dh44
neurons
act
through
glucose
metabolic
genes
drive
onset
rhythms.
Together,
our
data
suggest
changes
energetic
demands
developing
organisms
sleep-circadian
circuits
behaviors.
