Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development

Published: April 29, 2024

Sleep and feeding patterns lack strong daily rhythms during early life. As diurnal animals mature, is consolidated to the day sleep night. In Drosophila , circadian are initiated with formation of a circuit connecting central clock arousal output neurons; emergence also enables long-term memory (LTM). However, cues that trigger development this clock-arousal unknown. Here, we identify role for nutritional status in driving sleep-wake rhythm larvae. We find 2 nd instar larval period (L2), spread across day; these behaviors become organized into by 3 rd stage (L3). Forcing mature (L3) adopt immature (L2) strategies disrupts ability exhibit LTM. addition, (DN1a)-arousal (Dh44) itself influenced environment. Finally, demonstrate Dh44 neurons act through glucose metabolic genes drive onset rhythms. Together, our data suggest changes energetic demands developing organisms sleep-circadian circuits behaviors.

Language: Английский

Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 22, 2023

Sleep and feeding patterns lack strong daily rhythms during early life. As diurnal animals mature, is consolidated to the day sleep night. In

Language: Английский