Journal of Theoretical Biology,
Год журнала:
2024,
Номер
593, С. 111892 - 111892
Опубликована: Июнь 28, 2024
Across
early
childhood
development,
sleep
behavior
transitions
from
a
biphasic
pattern
(a
daytime
nap
and
nighttime
sleep)
to
monophasic
(only
sleep).
The
transition
consolidated
sleep,
which
occurs
in
most
children
between
2-
5-years-old,
is
major
developmental
milestone
reflects
interactions
the
developing
homeostatic
drive
circadian
system.
Using
physiologically-based
mathematical
model
of
sleep-wake
regulatory
network
constrained
by
observational
experimental
data
preschool-aged
participants,
we
analyze
how
developmentally-mediated
changes
may
contribute
napping
non-napping
patterns.
We
establish
baseline
identifying
parameter
sets
that
typical
2-year-old
5-year-old
behavior.
Then
vary
six
parameters
associated
with
dynamics
sensitivity
values
induce
sleep.
individual
contributions
these
patterning
independently
varying
their
age-dependent
trajectories.
Parameters
according
distinct
evolution
curves
produce
bifurcation
sequences
representing
various
ages
onset,
durations,
transitional
Finally,
consider
ability
light
schedules
reinforce
or
promote
respectively.
These
modeling
results
provide
insight
into
role
promoting
interindividual
variability
lay
foundations
for
identification
light-
behavior-based
interventions
healthy
consolidation
childhood.
eNeuro,
Год журнала:
2024,
Номер
11(3), С. ENEURO.0259 - 23.2024
Опубликована: Март 1, 2024
Nonoscillatory
measures
of
brain
activity
such
as
the
spectral
slope
and
Lempel–Ziv
complexity
are
affected
by
many
neurological
disorders
modulated
sleep.
A
multitude
frequency
ranges,
particularly
a
broadband
(encompassing
full
spectrum)
narrowband
approach,
have
been
used
especially
for
estimating
slope.
However,
effects
choosing
different
ranges
not
yet
explored
in
detail.
Here,
we
evaluated
impact
sleep
stage
task
engagement
(resting,
attention,
memory)
on
(30–45
Hz)
(1–45
range
28
healthy
male
human
subjects
(21.54
±
1.90
years)
using
within-subject
design
over
2
weeks
with
three
recording
nights
days
per
subject.
We
strived
to
determine
how
states
affect
two
perform
comparison.
In
range,
steepened,
decreased
continuously
from
wakefulness
N3
REM
sleep,
however,
was
best
discriminated
Importantly,
also
differed
between
tasks
during
wakefulness.
While
engagement,
flattened
both
ranges.
Interestingly,
only
positively
correlated
performance.
Our
results
show
that
sensitive
indices
state
variations
yields
more
information
could
be
greater
variety
research
questions
than
complexity,
when
is
used.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 20, 2024
Abstract
Contextual
cues
and
prior
evidence
guide
human
goal-directed
behavior.
The
neurophysiological
mechanisms
that
implement
contextual
priors
to
subsequent
actions
in
the
brain
remain
unclear.
Using
intracranial
electroencephalography
(iEEG),
we
demonstrate
increasing
uncertainty
introduces
a
shift
from
purely
oscillatory
mixed
processing
regime
with
an
additional
ramping
component.
Oscillatory
dynamics
reflect
dissociable
signatures,
which
likely
differentially
contribute
encoding
transfer
of
different
cognitive
variables
cue-guided
motor
task.
results
support
idea
prefrontal
activity
encodes
rules
ensuing
distinct
coding
subspaces,
while
theta
oscillations
synchronize
prefrontal-motor
network,
possibly
action
execution.
Collectively,
our
reveal
how
two
key
features
large-scale
neural
population
activity,
namely
continuous
synchrony,
jointly
rule-guided
Epilepsia,
Год журнала:
2024,
Номер
65(5), С. 1360 - 1373
Опубликована: Март 22, 2024
Abstract
Objectives
Responsive
neurostimulation
(RNS)
is
an
established
therapy
for
drug‐resistant
epilepsy
that
delivers
direct
electrical
brain
stimulation
in
response
to
detected
epileptiform
activity.
However,
despite
overall
reduction
seizure
frequency,
clinical
outcomes
are
variable,
and
few
patients
become
seizure‐free.
The
aim
of
this
retrospective
study
was
evaluate
aperiodic
electrophysiological
activity,
associated
with
excitation/inhibition
balance,
as
a
novel
electrographic
biomarker
aid
early
prognostication
the
RNS.
Methods
We
identified
intractable
mesial
temporal
lobe
who
were
implanted
RNS
System
between
2015
2021
at
University
Utah.
parameterized
neural
power
spectra
from
intracranial
recordings
during
first
3
months
following
implantation
into
periodic
components.
then
correlated
circadian
changes
parameters
baseline
most
recent
follow‐up.
Results
Seizure
significantly
patient's
average
change
day/night
exponent
(
r
=
.50,
p
.016,
n
23
patients)
oscillatory
alpha
.45,
.042,
across
recordings.
reached
its
maximum
nighttime
hours
(12
a.m.
6
a.m.)
responders
(i.e.,
least
50%
seizures).
Significance
These
findings
suggest
modulation
broadband
activity
therapy.
This
marker
has
potential
identify
likely
respond
Furthermore,
we
propose
less
may
be
related
dysfunction
balance
interconnected
role
epilepsy,
sleep,
memory.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 26, 2024
Abstract
The
aperiodic
(1/f-like)
component
of
electrophysiological
data
-
whereby
power
systematically
decreases
with
increasing
frequency,
as
quantified
by
the
exponent
has
been
shown
to
differentiate
sleep
stages.
Earlier
work,
however,
typically
focused
on
measuring
across
a
narrow
frequency
range.
In
this
we
sought
further
investigate
activity
during
extending
these
analyses
broader
ranges
and
considering
alternate
model
definitions.
This
included
‘knees’
in
component,
which
reflect
bends
spectrum,
indicating
change
exponent.
We
also
evaluate
temporal
dynamics
sleep.
To
do
so,
analyzed
from
two
sources:
intracranial
EEG
(iEEG)
106
epilepsy
patients
high-density
17
healthy
individuals,
measured
activity,
explicitly
comparing
different
forms.
doing
find
that
fitting
broadband
models
incorporating
‘knee’
feature
effectively
captures
sleep-stage-dependent
differences
well
relate
stage
transitions
responses
external
stimuli.
particular,
knee
parameter
shows
stage-specific
variation,
suggesting
an
interpretation
varying
timescales
These
results
demonstrate
examining
more
complex
reveals
novel
insights
interpretations
for
understanding
neural
Abstract
Despite
extensive
evidence
on
the
roles
of
non-rapid
eye
movement
(NREM)
and
REM
sleep
in
memory
processing,
a
comprehensive
model
that
integrates
their
complementary
functions
remains
elusive
due
to
lack
mechanistic
understanding
REM’s
role
offline
processing.
We
present
Refining
Rescuing
(RnR)
Hypothesis,
which
posits
principal
function
is
increase
signal-to-noise
ratio
within
across
representations.
As
such,
selectively
enhances
essential
nodes
representation
while
inhibiting
majority
(Refine).
Additionally,
modulates
weak
strong
representations
so
they
fall
similar
range
recallability
(Rescue).
Across
multiple
NREM-REM
cycles,
tuning
individual
traces
get
sharpened,
allowing
for
integration
shared
features
hypothesize
sleep’s
unique
cellular,
neuromodulatory,
electrophysiological
milieu,
marked
by
greater
inhibition
mixed
autonomic
state
both
sympathetic
parasympathetic
activity,
underpins
these
processes.
The
RnR
Hypothesis
offers
unified
framework
explains
diverse
behavioral
neural
outcomes
associated
with
sleep,
paving
way
future
research
more
sleep-dependent
cognitive
functions.
Theranostics,
Год журнала:
2025,
Номер
15(8), С. 3257 - 3274
Опубликована: Фев. 18, 2025
Rationale:
The
prelimbic
cortex
(PrL),
enriched
with
oxytocin
(OXT)
receptors,
plays
a
critical
role
in
memory
consolidation.
However,
the
of
OXT
social
consolidation
within
PrL
microcircuit
remains
poorly
understood.
Methods:
To
examine
signaling
consolidation,
we
used
biosensors
and
loss-of-function
approaches,
including
tetanus
toxin-mediated
silencing
neurons
paraventricular
nucleus
(PVNOXT),
optogenetic
inhibition
PVNOXT-PrL
pathway
during
rapid-eye-movement
(REM)
sleep,
local
administration
an
receptor
antagonist
PrL.
In
vivo
molecular
for
vasoactive
intestinal
peptide
(VIP),
somatostatin,
presynaptic
calcium
imaging
were
employed
to
assess
inhibitory
microcircuit.
Optogenetic
activation
intranasal
evaluate
resilience
chronic
sleep
deprivation-induced
deficits.
Results:
We
identified
that
REM-sleep
release
via
PVN
supports
deficiency
reduces
activity
VIP
parvalbumin
(PV)
neurons,
thereby
disrupting
balance
between
somatic
mediated
by
PV
dendritic
disinhibition
microcircuits
REM
sleep.
Chronic
deprivation
(SD)
disrupts
balance,
leading
pyramidal
neuron
hyperactivity
impairments.
Notably,
REM-sleep-specific
or
restores
rescues
deficits
SD
mice.
Conclusion:
Our
results
reveal
how
modulates
support
suggesting
potential
therapeutic
strategies
treating
sleep-related
disorders.
PLoS Computational Biology,
Год журнала:
2024,
Номер
20(10), С. e1012505 - e1012505
Опубликована: Окт. 21, 2024
Humans
sometimes
have
an
insight
that
leads
to
a
sudden
and
drastic
performance
improvement
on
the
task
they
are
working
on.
Sudden
strategy
adaptations
often
linked
insights,
considered
be
unique
aspect
of
human
cognition
tied
complex
processes
such
as
creativity
or
meta-cognitive
reasoning.
Here,
we
take
learning
perspective
ask
whether
insight-like
behaviour
can
occur
in
simple
artificial
neural
networks,
even
when
models
only
learn
form
input-output
associations
through
gradual
gradient
descent.
We
compared
dynamics
humans
regularised
networks
perceptual
decision
included
hidden
regularity
solve
more
efficiently.
Our
results
show
some
discover
this
regularity,
is
marked
by
abrupt
switch
reflects
aha-moment.
Notably,
find
with
rule
constant
rate
closely
mimicked
behavioural
characteristics
switches,
exhibiting
delay
insight,
suddenness
selective
occurrence
networks.
Analyses
network
architectures
revealed
crucially
depended
gating
mechanism
noise
added
updates,
which
allowed
accumulate
"silent
knowledge"
initially
suppressed
gating.
This
suggests
arise
from
where
it
combined
influences
noise,
regularisation.
These
potential
implications
for
systems,
brain,
guide
way
future
research.
