Intracranial
recordings
offer
unparalleled
spatiotemporal
resolution
in
the
study
of
human
memory.
In
this
chapter,
we
highlight
key
intracranial
recording
studies
that
have
provided
major
new
insights
into
neural
mechanisms
spatial
memory,
working
episodic
and
emotional
We
discuss
clinical
scenarios
been
used
to
examine
memory
humans
single
neuron,
field
potential,
electrical
stimulation
studies.
summarize
how
cell
by
now
revealed
several
functional
types
including
spatially
tuned
cells,
concept
visually
selective
cells
jointly
provide
cellular
level
insight
architecture
At
whole-brain
level,
emphasize
inter-areal
interactions
mediated
oscillations
are
a
critical
part
thereby
highlighting
interaction
different
perceptual,
cognitive
systems
service
eNeuro,
Год журнала:
2024,
Номер
11(3), С. ENEURO.0259 - 23.2024
Опубликована: Март 1, 2024
Nonoscillatory
measures
of
brain
activity
such
as
the
spectral
slope
and
Lempel–Ziv
complexity
are
affected
by
many
neurological
disorders
modulated
sleep.
A
multitude
frequency
ranges,
particularly
a
broadband
(encompassing
full
spectrum)
narrowband
approach,
have
been
used
especially
for
estimating
slope.
However,
effects
choosing
different
ranges
not
yet
explored
in
detail.
Here,
we
evaluated
impact
sleep
stage
task
engagement
(resting,
attention,
memory)
on
(30–45
Hz)
(1–45
range
28
healthy
male
human
subjects
(21.54
±
1.90
years)
using
within-subject
design
over
2
weeks
with
three
recording
nights
days
per
subject.
We
strived
to
determine
how
states
affect
two
perform
comparison.
In
range,
steepened,
decreased
continuously
from
wakefulness
N3
REM
sleep,
however,
was
best
discriminated
Importantly,
also
differed
between
tasks
during
wakefulness.
While
engagement,
flattened
both
ranges.
Interestingly,
only
positively
correlated
performance.
Our
results
show
that
sensitive
indices
state
variations
yields
more
information
could
be
greater
variety
research
questions
than
complexity,
when
is
used.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Янв. 20, 2024
Abstract
Contextual
cues
and
prior
evidence
guide
human
goal-directed
behavior.
The
neurophysiological
mechanisms
that
implement
contextual
priors
to
subsequent
actions
in
the
brain
remain
unclear.
Using
intracranial
electroencephalography
(iEEG),
we
demonstrate
increasing
uncertainty
introduces
a
shift
from
purely
oscillatory
mixed
processing
regime
with
an
additional
ramping
component.
Oscillatory
dynamics
reflect
dissociable
signatures,
which
likely
differentially
contribute
encoding
transfer
of
different
cognitive
variables
cue-guided
motor
task.
results
support
idea
prefrontal
activity
encodes
rules
ensuing
distinct
coding
subspaces,
while
theta
oscillations
synchronize
prefrontal-motor
network,
possibly
action
execution.
Collectively,
our
reveal
how
two
key
features
large-scale
neural
population
activity,
namely
continuous
synchrony,
jointly
rule-guided
Epilepsia,
Год журнала:
2024,
Номер
65(5), С. 1360 - 1373
Опубликована: Март 22, 2024
Abstract
Objectives
Responsive
neurostimulation
(RNS)
is
an
established
therapy
for
drug‐resistant
epilepsy
that
delivers
direct
electrical
brain
stimulation
in
response
to
detected
epileptiform
activity.
However,
despite
overall
reduction
seizure
frequency,
clinical
outcomes
are
variable,
and
few
patients
become
seizure‐free.
The
aim
of
this
retrospective
study
was
evaluate
aperiodic
electrophysiological
activity,
associated
with
excitation/inhibition
balance,
as
a
novel
electrographic
biomarker
aid
early
prognostication
the
RNS.
Methods
We
identified
intractable
mesial
temporal
lobe
who
were
implanted
RNS
System
between
2015
2021
at
University
Utah.
parameterized
neural
power
spectra
from
intracranial
recordings
during
first
3
months
following
implantation
into
periodic
components.
then
correlated
circadian
changes
parameters
baseline
most
recent
follow‐up.
Results
Seizure
significantly
patient's
average
change
day/night
exponent
(
r
=
.50,
p
.016,
n
23
patients)
oscillatory
alpha
.45,
.042,
across
recordings.
reached
its
maximum
nighttime
hours
(12
a.m.
6
a.m.)
responders
(i.e.,
least
50%
seizures).
Significance
These
findings
suggest
modulation
broadband
activity
therapy.
This
marker
has
potential
identify
likely
respond
Furthermore,
we
propose
less
may
be
related
dysfunction
balance
interconnected
role
epilepsy,
sleep,
memory.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 26, 2024
Abstract
The
aperiodic
(1/f-like)
component
of
electrophysiological
data
-
whereby
power
systematically
decreases
with
increasing
frequency,
as
quantified
by
the
exponent
has
been
shown
to
differentiate
sleep
stages.
Earlier
work,
however,
typically
focused
on
measuring
across
a
narrow
frequency
range.
In
this
we
sought
further
investigate
activity
during
extending
these
analyses
broader
ranges
and
considering
alternate
model
definitions.
This
included
‘knees’
in
component,
which
reflect
bends
spectrum,
indicating
change
exponent.
We
also
evaluate
temporal
dynamics
sleep.
To
do
so,
analyzed
from
two
sources:
intracranial
EEG
(iEEG)
106
epilepsy
patients
high-density
17
healthy
individuals,
measured
activity,
explicitly
comparing
different
forms.
doing
find
that
fitting
broadband
models
incorporating
‘knee’
feature
effectively
captures
sleep-stage-dependent
differences
well
relate
stage
transitions
responses
external
stimuli.
particular,
knee
parameter
shows
stage-specific
variation,
suggesting
an
interpretation
varying
timescales
These
results
demonstrate
examining
more
complex
reveals
novel
insights
interpretations
for
understanding
neural
Journal of Neuroscience Methods,
Год журнала:
2024,
Номер
408, С. 110160 - 110160
Опубликована: Май 9, 2024
Simultaneous
noninvasive
and
invasive
electrophysiological
recordings
provide
a
unique
opportunity
to
achieve
comprehensive
understanding
of
human
brain
activity,
much
like
Rosetta
stone
for
neuroscience.
In
this
review
we
focus
on
the
increasingly-used
powerful
combination
intracranial
electroencephalography
(iEEG)
with
scalp
(EEG)
or
magnetoencephalography
(MEG).
We
first
practical
insight
how
these
technically
challenging
recordings.
then
examples
from
clinical
research
simultaneous
are
advancing
our
epilepsy.
This
is
followed
by
illustration
neuroscience
methodological
advances
could
benefit
conclude
call
open
data
sharing
collaboration,
while
ensuring
neuroethical
approaches
argue
that
only
true
collaborative
approach
promises
will
be
fulfilled.
eNeuro,
Год журнала:
2024,
Номер
unknown, С. ENEURO.0242 - 24.2024
Опубликована: Авг. 13, 2024
Generalized
epilepsy
(GE)
encompasses
a
heterogenous
group
of
hyperexcitability
disorders
that
clinically
manifest
as
seizures.
At
the
whole-brain
level,
distinct
seizure
patterns
well
interictal
epileptic
discharges
(IEDs)
reflect
key
signatures
in
magneto-
and
electroencephalographic
(M/EEG)
recordings.
Moreover,
it
had
been
suggested
aperiodic
activity,
specifically
slope
1/ƒ
x
decay
function
power
spectrum,
might
index
neural
excitability.
However,
remained
unclear
if
encountered
at
cellular
level
directly
translates
to
putative
large-scale
excitability
signatures,
amenable
M/EEG.
In
order
test
whether
spectrum
is
altered
hyperexcitable
states,
we
recorded
resting
state
MEG
from
male
female
GE
patients
(n
=
51;
29
females;
28.82
±
12.18
years;
mean
SD)
age-matched
healthy
controls
49;
22
32.10
12.09
years).
We
parametrized
spectra
using
FOOOF
separate
oscillatory
activity
systematically
patients.
further
identified
IEDs
quantify
temporal
dynamics
around
overt
activity.
The
results
demonstrate
indexes
especially
during
epochs
when
no
were
present
(p
0.0130,
d
0.52).
Upon
IEDs,
circuits
transiently
shifted
less
excitable
network
0.001,
0.68).
sum,
these
uncover
background
based
on
current
brain
does
not
rely
presence
waveforms.
Significance
Statement
It
long
suspected
electric
disorders,
such
epilepsy.
To
date,
how
pathologic
can
be
quantified.
Kopf
et
al.
hyperexcitability,
absent;
hence,
providing
novel
non-invasively
biomarker
possibly
reflects
