Sleep disorders increase the risk of dementia, Alzheimer’s disease, and cognitive decline: a meta-analysis
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Abstract
Sleep
disorders,
particularly
insomnia
and
obstructive
sleep
apnea,
are
increasingly
implicated
as
significant
contributors
to
cognitive
decline,
dementia,
neurodegenerative
diseases
such
Alzheimer’s
disease
(AD)
vascular
impairment
dementia
(VCID).
However,
the
extent
specificity
of
these
associations
remain
uncertain.
This
meta-analysis
evaluates
impact
common
disorders
on
risk
developing
decline.
A
comprehensive
search
literature
was
conducted
identify
prospective
cohort
studies
assessing
risk.
Studies
reporting
estimates
for
AD,
or
decline
associated
with
insomnia,
other
(e.g.,
restless
legs
syndrome,
circadian
rhythm
excessive
daytime
sleepiness)
were
included.
Meta-analyses
performed
using
a
random-effects
model
calculate
pooled
hazard
ratios
(HRs)
95%
confidence
intervals
(CIs).
Thirty-nine
included,
subgroup
analyses
showing
between
all-cause
apnea
(HR
1.33,
CI
1.09–1.61),
1.36,
1.19–1.55),
1.24–1.43).
Obstructive
increased
AD
1.45,
1.24–1.69),
though
its
association
did
not
reach
statistical
significance
1.35,
0.99–1.84).
Insomnia
significantly
both
1.59,
1.01–2.51)
1.49,
1.27–1.74).
highlights
critical
role
in
risk,
emphasizing
need
early
detection
management
disturbances.
Targeted
interventions
could
play
pivotal
reducing
among
high-risk
populations.
Язык: Английский
OLFACTORY INTERVENTIONS FOR SLEEP ENHANCEMENT: A REVIEW
Universal Journal of Pharmaceutical Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Sleep
is
essential
for
cognitive
function,
emotional
balance,
and
overall
well-being.
Disruptions
like
insomnia
or
poor
sleep
quality
can
have
negative
consequences.
Various
methods,
including
bedtime
perfumes,
been
studied
to
improve
sleep.
This
review
examines
the
scientific
basis
of
scent-based
enhancement,
focusing
on
olfactory
system
effects
specific
aromatic
compounds
The
plays
a
crucial
role
in
how
scents
influence
Odor
molecules
bind
receptors
nasal
cavity,
sending
signals
bulb,
which
processes
these
relays
them
limbic
system.
connection
allows
evoke
responses
impact
Historically,
scent
therapy
has
used
across
cultures.
effectiveness
perfumes
depends
their
delivery
methods.
Diffusers,
sprays
roll-on
oils
are
common
ways
disperse
oils.
Incorporating
into
comprehensive
hygiene
routine,
consistent
schedule
calming
environment,
maximizes
benefits.
Future
research
should
identify
that
induce
sleep,
explore
interaction
between
stimuli
stages
investigate
long-term
safety
efficacy
perfumes.
In
conclusion,
through
power
scent.
Understanding
pathways,
historical
context
helps
individuals
make
informed
choices
about
using
fragrances.
Peer
Review
History:
Received
2
October
2024;
Reviewed
11
November;
Accepted
20
December;
Available
online
15
January
2025
Academic
Editor:
Dr.
Gehan
Fawzy
Abdel
Raoof
Kandeel,
Pharmacognosy
Department,
National
Research
Centre,
Dokki,
12622,
Giza,
Egypt,
[email protected]
Average
marks
at
initial
stage:
6.5/10
publication
7.0/10
Язык: Английский
Exploring the effects of combined nostalgic activities and music therapy on Alzheimer's disease outcomes
Frontiers in Psychology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 30, 2025
Objective
Exploring
the
effects
of
combination
nostalgic
activity-based
therapies,
including
music
therapy
on
cognitive
function,
negative
emotions,
and
sleep
quality
in
patients
with
mild
to
moderate
Alzheimer's
disease.
Methods
A
total
63
disease
who
were
treated
at
Sichuan
Provincial
Psychiatric
Center
People's
Hospital
Province
from
January
June
2023
selected
as
research
subjects.
They
randomly
divided
into
a
study
group
(
n
=
31)
control
32)
using
random
number
table
method.
The
received
routine
treatment
nursing
care,
while
intervention
basis
group.
Mini
Mental
State
Examination
(MMSE),
Montreal
Cognitive
Assessment
Scale
(MOCA),
Self
Rating
Anxiety
Depression
(SAS,
SDS),
Pittsburgh
Sleep
Quality
Index
(PSQI)
two
groups
compared.
Results
30
cases
each
completed
study.
After
12
weeks
intervention,
MMSE
MOCA
scores
both
increased,
was
higher
than
P
<
0.05);
SAS,
SDS
PSQI
decreased
compared
those
before
lower
0.05).
Conclusion
Nostalgic
can
improve
alleviate
Язык: Английский
Decoding Multifaceted Roles of Sleep-Related Genes as Molecular Bridges in Chronic Disease Pathogenesis
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 2872 - 2872
Опубликована: Март 21, 2025
Sleep
is
a
fundamental
process
essential
for
all
organisms.
deprivation
can
lead
to
significant
detrimental
effects,
contributing
various
physiological
disorders
and
elevating
the
risk
of
several
diseases.
Investigating
relationship
between
sleep
human
diseases
offers
valuable
insights
into
molecular
mechanisms
governing
regulation,
potentially
guiding
development
more
effective
treatments
associated
This
study
explored
roles
sleep-related
genes
in
biological
processes
their
associations
with
chronic
diseases,
mainly
including
neurological,
metabolic,
cardiovascular
cancer.
Additionally,
an
analysis
on
was
also
performed
understand
potential
role
tumorigenesis.
review
aims
enhance
understanding
link
novel
therapeutic
approaches
targeting
circadian
rhythm-related
Язык: Английский