Frontier applications of retinal nanomedicine: progress, challenges and perspectives
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 25, 2025
The
human
retina
is
a
fragile
and
sophisticated
light-sensitive
tissue
in
the
central
nervous
system.
Unhealthy
retinas
can
cause
irreversible
visual
deterioration
permanent
vision
loss.
Effective
therapeutic
strategies
are
restricted
to
treatment
or
reversal
of
these
conditions.
In
recent
years,
nanoscience
nanotechnology
have
revolutionized
targeted
management
retinal
diseases.
Pharmaceuticals,
theranostics,
regenerative
medicine,
gene
therapy,
prostheses
indispensable
for
interventions
been
significantly
advanced
by
nanomedical
innovations.
Hence,
this
review
presents
novel
insights
into
use
versatile
nanomaterial-based
nanocomposites
frontier
applications,
including
non-invasive
drug
delivery,
theranostic
contrast
agents,
nanoagents,
stem
cell-based
optogenetics
prostheses,
which
mainly
reported
within
last
5
years.
Furthermore,
progress,
potential
challenges,
future
perspectives
field
highlighted
discussed
detail,
may
shed
light
on
clinical
translations
ultimately,
benefit
patients
with
disorders.
Язык: Английский
Compartmentalization of proteasomes in lipid rafts and exosomes: unveiling molecular interactions in vaping-related cellular processes
Archives of Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Язык: Английский
Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics
Molecular Cancer,
Год журнала:
2025,
Номер
24(1)
Опубликована: Май 7, 2025
Abstract
Protein
lipidation
is
a
pivotal
post-translational
modification
that
increases
protein
hydrophobicity
and
influences
their
function,
localization,
interaction
network.
Emerging
evidence
has
shown
significant
roles
of
in
the
tumor
microenvironment
(TME).
However,
comprehensive
review
this
topic
lacking.
In
review,
we
present
an
integrated
in-depth
literature
context
TME.
Specifically,
focus
on
three
major
modifications:
S-
prenylation,
palmitoylation,
N-
myristoylation.
We
emphasize
how
these
modifications
affect
oncogenic
signaling
pathways
complex
interplay
between
cells
surrounding
stromal
immune
cells.
Furthermore,
explore
therapeutic
potential
targeting
mechanisms
cancer
treatment
discuss
prospects
for
developing
novel
anticancer
strategies
disrupt
lipidation-dependent
pathways.
By
bridging
with
dynamics
TME,
our
provides
insights
into
relationship
them
drives
initiation
progression.
Язык: Английский
哺乳动物细胞蛋白质折叠和内质网相关降解的研究进展
Journal of Zhejiang University SCIENCE B,
Год журнала:
2024,
Номер
25(3), С. 212 - 232
Опубликована: Март 1, 2024
Язык: Английский
Precise control of transmembrane current via regulating bionic lipid membrane composition
Science Advances,
Год журнала:
2024,
Номер
10(35)
Опубликована: Авг. 30, 2024
The
transport
of
ions
through
biological
ion
channels
is
regulated
not
only
by
their
structural
characteristics
but
also
the
composition
phospholipid
membrane,
which
serves
as
a
carrier
for
nanochannels.
Inspired
modulation
currents
lipid
membrane
composition,
exemplified
activation
K
Язык: Английский
Regulation of Transmembrane Current through Modulation of Biomimetic Lipid Membrane Composition
Faraday Discussions,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 23, 2024
Ion
transport
through
biological
channels
is
influenced
not
only
by
the
structural
properties
of
themselves
but
also
composition
phospholipid
membrane,
which
acts
as
a
scaffold
for
these
nanochannels.
Drawing
inspiration
from
how
lipid
membrane
modulates
ion
currents,
seen
in
activation
K
Язык: Английский
Targeting n-myristoyltransferases promotes a pan-Mammarenavirus inhibition through the degradation of the Z matrix protein
PLoS Pathogens,
Год журнала:
2024,
Номер
20(12), С. e1012715 - e1012715
Опубликована: Дек. 3, 2024
Several
Old
World
and
New
Mammarenavirus
are
responsible
for
hemorrhagic
fever
in
humans.
These
enveloped
viruses
have
a
bi-segmented
ambisense
RNA
genome
that
encodes
four
proteins.
All
identified
to
date
share
common
dependency
on
myristoylation:
the
addition
of
C14
myristic
acid
N-terminal
G2
residue
two
their
The
myristoylation
Z
matrix
protein
is
required
viral
particle
budding,
while
signal
peptide
envelope
glycoproteins
important
entry
mechanism.
Using
Mopeia
virus
as
model,
we
characterized
interaction
with
N-Myristoyltransferases
(NMT)
1
2,
enzymes
mammals.
While
both
were
capable
interact
Z,
showed
only
NMT1
was
production
progeny,
endogenous
expression
NMT2
being
insufficient
make
up
its
absence.
high
affinity
inhibitors
NMTs,
IMP1088
DDD85646,
demonstrated
strong,
dose
dependent
specific
inhibition
at
nanomolar
range
all
tested,
including
highly
pathogenic
Lassa,
Machupo,
Junin
Lujo
viruses.
Mechanistically,
DDD85646
blocked
between
preventing
further
formation,
egress
spread.
Unexpectedly,
found
devoid
myristate,
despite
fully
translated,
did
not
accumulate
other
proteins
infected
cells
but
instead
degraded
proteasome-
autophagy-independent
manner.
molecules
represent
new
broad-spectrum
class
against
.
Язык: Английский
Inhibition of hostN-myristoylation compromises the infectivity of SARS-CoV-2 due to Golgi-bypassing egress from lysosomes and endoplasmic reticulum
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 3, 2023
Abstract
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2),
which
caused
the
disease
2019
(COVID-19)
pandemic,
remains
a
global
health
concern
despite
vaccines,
neutralizing
antibodies,
and
antiviral
drugs.
Emerging
mutations
can
reduce
effectiveness
of
these
treatments,
suggesting
that
targeting
host
cell
factors
may
be
valuable
alternative.
N
-myristoyltransferases
(NMT)
are
essential
enzymes
for
protein
-myristoylation,
affecting
stability,
interaction,
localization,
function
numerous
proteins.
We
demonstrate
selective
inhibition
NMT
decreases
SARS-CoV-2
infection
by
90%
in
human
lung
primary
nasal
epithelial
cells,
choroid
plexus-cortical
neuron
organoids.
does
not
affect
viral
entry,
replication
or
release,
but
impairs
maturation
incorporation
envelope
proteins
into
newly
assembled
virions,
leading
to
compromised
infectivity
released
virions.
The
triggers
Golgi-bypassing
pathway
progeny
virion
egress,
occurs
through
endoplasmic
reticulum
lysosomal
intermediates.
Язык: Английский