Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug
Nature Communications,
Год журнала:
2025,
Номер
16(1)
Опубликована: Март 15, 2025
Abstract
Motor
disability
is
a
critical
impairment
in
stroke
patients.
Rehabilitation
has
limited
effect
on
recovery;
but
there
no
medical
therapy
for
post-stroke
recovery.
The
biological
mechanisms
of
rehabilitation
the
brain
remain
unknown.
Here,
using
photothrombotic
model
male
mice,
we
demonstrate
that
after
selectively
enhances
synapse
formation
presynaptic
parvalbumin
interneurons
and
postsynaptic
neurons
rostral
forelimb
motor
area
with
axonal
projections
to
caudal
where
was
induced
(stroke-projecting
neuron).
improves
performance
neuronal
functional
connectivity,
while
inhibition
stroke-projecting
diminishes
Stroke-projecting
show
decreased
dendritic
spine
density,
reduced
external
synaptic
inputs,
lower
proportion
total
GABAergic
input.
Parvalbumin
regulate
their
activation
during
training
necessary
Furthermore,
gamma
oscillation,
parvalbumin-regulated
rhythm,
increased
rehabilitation-induced
recovery
animals
Pharmacological
enhancement
interneuron
function
stroke,
reproducing
These
findings
identify
circuits
mediate
rehabilitation-recovery
possibility
rational
selection
pharmacological
agents
deliver
first
molecular-rehabilitation
therapeutic.
Язык: Английский
Parvalbumin interneuron cell-to-network plasticity: mechanisms and therapeutic avenues
Trends in Pharmacological Sciences,
Год журнала:
2024,
Номер
45(7), С. 586 - 601
Опубликована: Май 18, 2024
Alzheimer's
disease
(AD)
and
schizophrenia
(SCZ)
represent
two
major
neuropathological
conditions
with
a
high
burden.
Despite
their
distinct
etiologies,
patients
suffering
from
AD
or
SCZ
share
common
burden
of
disrupted
memory
functions
unattended
by
current
therapies.
Recent
preclinical
analyses
highlight
cell-type-specific
contributions
parvalbumin
interneurons
(PVIs),
particularly
the
plasticity
cellular
excitability,
towards
intact
neuronal
network
function
(cell-to-network
plasticity)
performance.
Here
we
argue
that
deficits
PVI
cell-to-network
may
underlie
in
SCZ,
explore
therapeutic
avenues:
targeting
PVI-specific
neuromodulation,
including
neuropeptides,
recruitment
synchrony
gamma
frequency
range
(40
Hz)
external
stimulation.
We
finally
propose
these
approaches
be
merged
under
consideration
recent
insights
into
human
brain
physiology.
Язык: Английский
The Role of Parvalbumin Interneurons in Autism Spectrum Disorder
Journal of Neuroscience Research,
Год журнала:
2024,
Номер
102(10)
Опубликована: Окт. 1, 2024
ABSTRACT
As
an
important
subtype
of
GABAergic
interneurons,
parvalbumin
(
PV
)
interneurons
play
a
critical
role
in
regulating
cortical
circuits
and
neural
networks.
Abnormalities
the
development
or
function
have
been
linked
to
autism
spectrum
disorder
(ASD),
neurodevelopmental
characterized
by
social
language
deficits.
In
this
review,
we
focus
on
abnormalities
ASD
,
including
quantity
discuss
underlying
mechanisms
impairments
pathology
.
Finally,
propose
potential
therapeutic
approaches
targeting
such
as
transplanting
MGE
progenitor
cells
utilizing
optogenetic
stimulation
treatment
ASD.
Язык: Английский
Advancing personalized digital therapeutics: integrating music therapy, brainwave entrainment methods, and AI-driven biofeedback
Frontiers in Digital Health,
Год журнала:
2025,
Номер
7
Опубликована: Фев. 25, 2025
Mental
health
disorders
and
cognitive
decline
are
pressing
global
concerns,
increasing
the
demand
for
non-pharmacological
interventions
targeting
emotional
dysregulation,
memory
deficits,
neural
dysfunction.
This
review
systematically
examines
three
promising
methodologies-music
therapy,
brainwave
entrainment
(binaural
beats,
isochronic
tones,
multisensory
stimulation),
their
integration
into
a
unified
therapeutic
paradigm.
Emerging
evidence
indicates
that
music
therapy
modulates
affect,
reduces
stress,
enhances
cognition
by
engaging
limbic,
prefrontal,
reward
circuits.
Brainwave
entrainment,
particularly
within
gamma
frequency
range
(30-100
Hz),
facilitates
oscillatory
patterns
linked
to
relaxation,
concentration,
memory,
with
40
Hz
showing
promise
enhancement,
albeit
individual
variability.
Synchronized
stimulation,
combining
auditory
visual
inputs
at
frequencies,
has
demonstrated
potential
in
enhancing
supporting
integrity,
Alzheimer's
disease.
However,
challenges
such
as
patient
response
variability,
lack
of
standardization,
scalability
hinder
widespread
implementation.
Recent
research
suggests
synergistic
application
these
modalities
may
optimize
outcomes
leveraging
complementary
mechanisms.
To
actualize
this,
AI-driven
biofeedback,
enabling
real-time
physiological
assessment
individualized
adjustments-such
tailoring
musical
complexity,
components-emerges
solution.
adaptive
model
treatment
accessibility
consistency
while
maximizing
long-term
efficacy.
Although
early
stages,
preliminary
highlights
its
transformative
reshaping
strategies.
Advancing
this
field
requires
interdisciplinary
research,
rigorous
evaluation,
ethical
data
stewardship
develop
innovative,
patient-centered
solutions
mental
rehabilitation.
Язык: Английский
The relationship between neuromagnetic networks and cognitive impairment in self‐limited epilepsy with centrotemporal spikes
Epilepsia Open,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Abstract
Objective
This
was
an
exploratory
study
designed
to
examine
the
alterations
in
neuromagnetic
networks
within
brain
regions
involved
cognitive
functions
children
with
self‐limited
epilepsy
centrotemporal
spikes
(SeLECTS).
Additionally,
it
sought
explore
relationship
between
these
neural
network
differences
and
impairment.
Methods
Magnetoencephalography
(MEG)
data
were
collected
from
63
drug‐naïve
diagnosed
SeLECTS
30
healthy
controls
(HC).
Functional
connectivity
(FC)
across
26
cognitive‐related
regions,
as
defined
by
Desikan‐Killiany,
assessed
using
corrected
amplitude
envelope
correlation
(AEC‐c)
analysis.
The
function
of
evaluated
fourth
edition
Wechsler
Intelligence
Scale
for
Children
(WISC‐IV).
Spearman's
analysis
then
performed
assess
AEC‐c
values
WISC‐IV
indices.
Results
showed
reduced
FC
delta
band
left
rostral
middle
frontal
(rMFG.L)
anterior
cingulate
(rACC.L),
well
gamma2
superior
(SFG.L)
rACC
on
both
sides,
compared
HC
(
p
<
0.05).
On
other
hand,
several
enhanced,
including
those
rMFG
right
rACC,
caudal
(CMF.L),
(CMF.R)
supramarginal
(SMG.R),
specifically
gamma1
A
revealed
a
positive
association
Verbal
Comprehension
Index
(VCI)
scores
(R
=
0.4228,
Significance
findings
this
that
exhibited
significant
associated
cognition,
especially
gamma
frequency
bands,
when
HC.
We
also
found
are
significantly
correlated
verbal
comprehension
ability,
which
may
contribute
understanding
mechanisms
underlying
weaknesses
SeLECTS.
Furthermore,
our
provide
hypotheses
future
work
dedicated
further
exploring
impairment
Plain
Language
Summary
Based
magnetoencephalography
technology
(MEG),
there
HC,
relevant
indicators
Scale.
finding
suggested
serve
imaging
markers
predict
changes
Язык: Английский
Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations
Neurobiology of Disease,
Год журнала:
2025,
Номер
unknown, С. 106937 - 106937
Опубликована: Май 1, 2025
Язык: Английский
Mechanisms and implications of gamma oscillation plasticity
Trends in Neurosciences,
Год журнала:
2024,
Номер
unknown
Опубликована: Май 1, 2024
A
recent
study
by
Hadler
and
colleagues
uncovered
a
novel
form
of
plasticity
gamma
oscillations
in
an
ex
vivo
hippocampal
slice
preparation
which
they
term
'gamma
potentiation'.
We
discuss
the
potential
cellular
mechanisms
this
its
functional
translational
implications.
Язык: Английский
A role for δ subunit-containing GABAAreceptors on parvalbumin positive neurons in maintaining electrocortical signatures of sleep states
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Март 29, 2024
Abstract
GABA
A
receptors
containing
δ
subunits
have
been
shown
to
mediate
tonic/slow
inhibition
in
the
CNS.
These
are
typically
found
extrasynaptically
and
activated
by
relatively
low
levels
of
ambient
extracellular
space.
In
mouse
neocortex,
expressed
on
surface
some
pyramidal
cells
as
well
parvalbumin
positive
(PV+)
interneurons.
An
important
function
PV+
interneurons
is
organization
coordinated
network
activity
that
can
be
measured
EEG;
however,
it
remains
unclear
what
role
inhibitory
control
neurons
may
play
shaping
oscillatory
activity.
After
confirming
a
loss
functional
mediated
tonic
currents
PV
cortical
slices
from
mice
lacking
Gabrd
(PV
δcKO),
we
performed
EEG
recordings
survey
across
wake
sleep
states.
δcKO
showed
altered
spectral
content
during
NREM
REM
was
result
increased
emergence
transient
high
amplitude
bursts
theta
frequency
REM.
Viral
reintroduction
rescued
phenotypes,
supporting
an
for
subunit
maintaining
normal
oscillations.
Significance
statement
The
impact
studied
deleting
receptor
selectively
these
neurons.
We
discovered
unexpected
changes
at
frequencies
were
viral
reintroduction.
Язык: Английский
Defects of parvalbumin-positive interneurons are implicated in psychiatric disorders
Biochemical Pharmacology,
Год журнала:
2024,
Номер
unknown, С. 116599 - 116599
Опубликована: Окт. 1, 2024
Язык: Английский
Bimodal dendritic processing in basket cells drives distinct memory-related oscillations
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 14, 2024
Abstract
Hippocampal
oscillations
regulate
distinct
memory
stages
and
behavioral
states,
yet
the
mechanisms
by
which
interneurons
contribute
to
these
rhythms
remain
elusive.
Here,
we
establish
a
novel
link
between
bimodal
nonlinear
dendritic
processing
of
PV+
fast-spiking
basket
cells
(FSBCs)
hippocampal
oscillations.
Our
model
predicts
that
FSBCs
can
flexibly
adjust
their
activity
without
changes
in
synaptic
input
quantity,
leveraging
supralinear
sublinear
branches
selectively
shape
network
dynamics.
Supralinear
activation
enhances
high-frequency
oscillations,
while
amplifies
slow
oscillatory
power,
dynamically
modulating
excitation/inhibition
(E/I)
balance.
These
findings
reveal
previously
unrecognized
role
FSBC
integration
memory-related
dynamics,
offering
new
insights
into
cellular
governing
rhythm
generation.
Significance
Statement
play
crucial
processes,
how
remains
unresolved.
study
reveals
exploit
fast
components,
independently
quantity.
This
energy-efficient
mechanism
allows
fine-tune
excitation-inhibition
balance,
dynamics
essential
for
learning
consolidation.
By
challenging
conventional
view
interneuron
function,
our
redefine
inhibitory
circuits
generation,
providing
basis
Язык: Английский