Materials Today, Год журнала: 2024, Номер unknown
Опубликована: Дек. 1, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101595 - 101595
Опубликована: Фев. 19, 2025
Язык: Английский
Процитировано
5
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Янв. 12, 2025
The management of diabetic wounds faces significant challenges due to the excessive activation reactive oxygen species (ROS), dysregulation inflammatory response, and impaired angiogenesis. A substantial body evidence suggests that aforementioned diverse factors contributing delayed healing may be associated with autophagy. Impaired autophagy leads endothelial fibroblast dysfunction impedes macrophage phenotypic transformation. This disruption hinders angiogenesis extracellular matrix deposition, ultimately culminating in wound healing. Therefore, biomaterials possessing regulatory functions hold potential for clinical applications enhancing wounds. hybrid multifunctional hydrogel (GelMa@SIS-Qu) has been developed, comprising methacrylamide gelatin (GelMa), a small intestine submucosal acellular (SIS), quercetin nanoparticles, which demonstrates capability promote promotion not only reduces ROS levels cells enhances their antioxidant activity but also mitigates ROS-induced cell apoptosis, thereby promoting Furthermore, facilitates transformation macrophages from M1 phenotype M2 phenotype. study investigates distinctive mechanisms GelMa@SIS-Qu proposes promising therapeutic strategy treating diabetes-related
Язык: Английский
Процитировано
3
Bioactive Materials, Год журнала: 2024, Номер 41, С. 385 - 399
Опубликована: Июль 30, 2024
Infected wounds pose a significant clinical challenge due to bacterial resistance, recurrent infections, and impaired healing. Reactive oxygen species (ROS)-based strategies have shown promise in eradicating infections. However, the excess ROS infection site after treatments may cause irreversible damage healthy tissues. To address this issue, we developed bovine serum albumin-iridium oxide nanoclusters (BSA-IrO
Язык: Английский
Процитировано
10
Research, Год журнала: 2025, Номер 8
Опубликована: Янв. 1, 2025
Slow wound healing in the elderly has attracted much attention recently due to associated infection risks and decreased longevity. The “brain–skin axis” theory suggests that abnormalities brain nervous system can lead skin degeneration because abnormal mental states, like chronic stress, have negative physiological functional effects on through a variety of processes, resulting delayed accelerated aging. However, it remains unclear whether maintaining youthful beneficial aged healing. In light this, we identified brain-derived extracellular vesicles (YBEVs) created composite GelMA hydrogel material encourages scarless skin. We found YBEVs reduce expression senescence, senescence-associated secretory phenotypes, inflammation-associated proteins, even restore dysfunction senescent cells. Furthermore, by encouraging collagen deposition, angiogenesis, epidermal dermal regeneration, folliculogenesis, demonstrated YBEV-containing hydrogels wounds rats. pro-repairing speed effect this matched young Subsequent proteomic analysis revealed presence numerous proteins within YBEVs, some which may play role regulation energy intake, particularly oxidative phosphorylation mitochondrial function. conclusion, findings suggest could potentially alleviate aging, proposed YBEVs-GelMA emerges as promising strategy for addressing age-related impairments
Язык: Английский
Процитировано
1
Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112255 - 112255
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Molecules, Год журнала: 2025, Номер 30(4), С. 816 - 816
Опубликована: Фев. 10, 2025
Aging represents a complex biological phenomenon marked by the progressive deterioration of physiological functions over time, reduced resilience, and increased vulnerability to age-related diseases, ultimately culminating in mortality. Recent research has uncovered diverse molecular mechanisms through which metformin extends its benefits beyond glycemic control, presenting it as promising intervention against aging. This review delves into anti-aging properties metformin, highlighting role mitochondrial energy modulation, activation AMPK-mTOR signaling pathway, stimulation autophagy, mitigation inflammation linked cellular Furthermore, we discuss influence on epigenetic modifications that underpin genomic stability homeostasis. Metformin's potential addressing age-associated disorders including metabolic, cardiovascular, neurodegenerative diseases is also explored. The Targeting with Metformin (TAME) trial aims provide key evidence efficacy delaying aging humans. Despite these insights, significant challenges persist gaining more comprehensive understanding underlying mechanisms, determining optimal dosing strategies, evaluating long-term safety non-diabetic populations. Addressing crucial fully realizing metformin's an therapeutic.
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2024, Номер 497, С. 154433 - 154433
Опубликована: Июль 31, 2024
Язык: Английский
Процитировано
6
Bioactive Materials, Год журнала: 2024, Номер 36, С. 524 - 540
Опубликована: Июнь 1, 2024
Pulpitis, an inflammatory disease of dental pulp tissues, ultimately results in the loss defense properties. Existing clinical modalities cannot effectively promote inflamed repair. Oxidative stress is a major obstacle inhibiting Due to their powerful antioxidative capacity, mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) exhibit potential for treating oxidative stress-related disorders. However, whether MSC-sEVs shield tissues from damage largely unknown. Here, we showed that follicle sEVs (DFSC-sEVs) have and prohealing effects on rat LPS-induced pulpitis model by enhancing survival, proliferation odontogenesis H2O2-injured cells (DPSCs). Additionally, DFSC-sEVs restored oxidative/antioxidative balance DPSC mitochondria had comparable ameliorating mitochondrial dysfunction with mitochondrion-targeted antioxidant Mito-Tempo. To improve efficacy DFSC-sEVs, fabricated intelligent injectable hydrogel release combining sodium alginate (SA) ROS sensor RhB-AC. The newly formed SA-RhB efficiently encapsulates exhibits controlled HClO/ClO− concentration-dependent manner, providing synergistic effect DFSC-sEVs. These suggest DFSC-sEVs-loaded promising minimally invasive treatment tissue repair wound microenvironment.
Язык: Английский
Процитировано
5
Опубликована: Янв. 1, 2025
Periodontitis is an intractable chronic inflammatory disease characterized by excessive proinflammatory factors production and reactive oxygen species (ROS) accumulation. Nanodrugs have made significant contributions in the biomedical field but fall short as periodontitis therapeutics because of their singular effects, low retention rates, poor specificity, insufficient biocompatibility. Herein, we report a functionalized periodontal ligament stem cell (PDLSC) membrane-camouflaged MnO2 nanoplatform (MnO2@hPM) to target reprogram microenvironment periodontitis. PDLSC-affinity biological molecules hypoxia-educated proteins on membrane coating endow MnO2@hPM with capacities actively PDLSCs under environment, concurrently neutralize various factors, scavenge overburdened ROS. The synergistic effects inflammation inhibition ROS elimination mitigate mitochondrial dysfunction, improve metabolic disturbance, restore osteogenic potential inflammation-impaired PDLSCs. In vivo, effectively accumulates at sites, significantly ameliorates inflammation, alleviates bone loss artificial periodontitis, showing optimized therapeutic performance for tissue reconstruction. This multirisk-rescuing biomimetic nanozyme good biocompatibility exhibits inflammation-targeting ability benefits against highlighting its advanced therapy other diseases.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер 506, С. 160119 - 160119
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0