Epigenetic and metabolic regulation of developmental timing in neocortex evolution
Trends in Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
The
human
brain
is
characterized
by
impressive
cognitive
abilities.
neocortex
the
seat
of
higher
cognition,
and
expansion
a
hallmark
evolution.
While
developmental
programs
are
similar
in
different
species,
timing
transitions
capacity
neural
progenitor
cells
(NPCs)
to
proliferate
differ,
contributing
increased
production
neurons
during
cortical
development.
Here,
we
review
epigenetic
regulation
corticogenesis,
focusing
mostly
on
humans
while
building
knowledge
from
studies
mice.
We
discuss
metabolic-epigenetic
interplay
as
potential
mechanism
integrate
extracellular
signals
into
chromatin.
Moreover,
synthesize
current
understanding
how
metabolic
deregulation
can
cause
neurodevelopmental
disorders.
Finally,
outline
be
investigated
using
organoid
models.
Язык: Английский
The Critical Balance Between Quiescence and Reactivation of Neural Stem Cells
Biomolecules,
Год журнала:
2025,
Номер
15(5), С. 672 - 672
Опубликована: Май 6, 2025
Neural
stem
cells
(NSC)
are
multipotent,
self-renewing
that
give
rise
to
all
neural
cell
types
within
the
central
nervous
system.
During
adulthood,
most
NSCs
exist
in
a
quiescent
state
which
can
be
reactivated
response
metabolic
and
signalling
changes,
allowing
for
long-term
continuous
neurogenesis
injury.
Ensuring
critical
balance
between
quiescence
reactivation
is
required
maintain
limited
NSC
reservoir
replenishment
throughout
lifetime.
The
precise
mechanisms
pathways
behind
this
at
focus
of
current
research.
In
review,
we
highlight
discuss
recent
studies
using
Drosophila,
mammalian
zebrafish
models
contributing
understanding
molecular
underlying
NSCs.
Язык: Английский