The Critical Balance Between Quiescence and Reactivation of Neural Stem Cells DOI Creative Commons
Adam M. Elkin, Sarah Robbins, Claudia S. Barros

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 672 - 672

Published: May 6, 2025

Neural stem cells (NSC) are multipotent, self-renewing that give rise to all neural cell types within the central nervous system. During adulthood, most NSCs exist in a quiescent state which can be reactivated response metabolic and signalling changes, allowing for long-term continuous neurogenesis injury. Ensuring critical balance between quiescence reactivation is required maintain limited NSC reservoir replenishment throughout lifetime. The precise mechanisms pathways behind this at focus of current research. In review, we highlight discuss recent studies using Drosophila, mammalian zebrafish models contributing understanding molecular underlying NSCs.

Language: Английский

Epigenetic and metabolic regulation of developmental timing in neocortex evolution DOI Creative Commons

Matilde Aquilino,

Nora Ditzer, Takashi Namba

et al.

Trends in Neurosciences, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

The human brain is characterized by impressive cognitive abilities. neocortex the seat of higher cognition, and expansion a hallmark evolution. While developmental programs are similar in different species, timing transitions capacity neural progenitor cells (NPCs) to proliferate differ, contributing increased production neurons during cortical development. Here, we review epigenetic regulation corticogenesis, focusing mostly on humans while building knowledge from studies mice. We discuss metabolic-epigenetic interplay as potential mechanism integrate extracellular signals into chromatin. Moreover, synthesize current understanding how metabolic deregulation can cause neurodevelopmental disorders. Finally, outline be investigated using organoid models.

Language: Английский

Citations

0
The Critical Balance Between Quiescence and Reactivation of Neural Stem Cells DOI Creative Commons
Adam M. Elkin, Sarah Robbins, Claudia S. Barros

et al.

Biomolecules, Journal Year: 2025, Volume and Issue: 15(5), P. 672 - 672

Published: May 6, 2025

Neural stem cells (NSC) are multipotent, self-renewing that give rise to all neural cell types within the central nervous system. During adulthood, most NSCs exist in a quiescent state which can be reactivated response metabolic and signalling changes, allowing for long-term continuous neurogenesis injury. Ensuring critical balance between quiescence reactivation is required maintain limited NSC reservoir replenishment throughout lifetime. The precise mechanisms pathways behind this at focus of current research. In review, we highlight discuss recent studies using Drosophila, mammalian zebrafish models contributing understanding molecular underlying NSCs.

Language: Английский

Citations

0