A Cascade of Microbiota-Leaky Gut-Inflammation- Is it a Key Player in Metabolic Disorders?

Current Obesity Reports, Год журнала: 2025, Номер 14(1)

Опубликована: Апрель 10, 2025

Язык: Английский

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Emerging Roles of Modern Lifestyle Factors in Microbiome Stability and Functionality

Current Clinical Microbiology Reports, Год журнала: 2025, Номер 12(1)

Опубликована: Март 12, 2025

Язык: Английский

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Linking microbiome to cancer: A mini-review on contemporary advances

The Microbe, Год журнала: 2025, Номер unknown, С. 100279 - 100279

Опубликована: Фев. 1, 2025

Язык: Английский

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Therapeutic Potential of Prunus Species in Gastrointestinal Oncology

Cancers, Год журнала: 2025, Номер 17(6), С. 938 - 938

Опубликована: Март 10, 2025

Background: Gastrointestinal tract cancers represent a significant worldwide health concern, accounting for almost one-third of cancer-related deaths. The existing chemotherapy drugs used in gastrointestinal are ineffective, so prognosis is poor, recurrence and metastasis rates high, survival time remains short, necessitating the development novel antitumor that exhibit low toxicity less potential drug resistance. This challenge considerable, but evidence from past decades supports medicinal properties functionalities bioactive compounds such as flavonoids acid phenolics with anticancer activities. Our purpose was to find data on relationship between cancer Prunus species, focusing their molecular mechanisms action. Results: Studies highlight species modulate cell signaling pathways involved tumorigenesis. Conclusions: studies reviewed suggest polyphenols promising activities could an adjunctive therapeutic strategy treatment. Further necessary validate these compounds’ feasibility cost-effective treatments cancer.

Язык: Английский

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Microbiome analysis uncovers fruit-specific microbial community divergence between wild and cultivated watermelon varieties

Vegetable Research, Год журнала: 2025, Номер 5(1), С. 0 - 0

Опубликована: Янв. 1, 2025

Язык: Английский

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Role of gut microbiome in suppression of cancers

Gut Microbes, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 20, 2025

The pathogenesis of cancer is closely related to the disruption homeostasis in human body. gut microbiome plays crucial roles maintaining its host throughout lifespan. In recent years, a large number studies have shown that dysbiosis involved entire process initiation, development, and prognosis by influencing immune system metabolism. Some specific intestinal bacteria promote occurrence development cancers under certain conditions. Conversely, some other suppress oncogenesis progression cancers, including inhibiting delaying boosting therapeutic effect on cancers. promoting effects been comprehensively discussed previous review. This article will review latest advances mechanisms suppression, providing new perspective for developing strategies prevention treatment.

Язык: Английский

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Inverted day-night feeding during pregnancy affects the brain health of both maternal and fetal brains through increasing inflammation levels associated with dysbiosis of the gut microbiome in rats

Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)

Опубликована: Май 2, 2025

Язык: Английский

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Single-cell and bulk transcriptome sequencing identifies circadian rhythm disruption and cluster-specific clinical insights in colorectal tumorigenesis

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Май 8, 2025

Colorectal cancer (CRC) is one of the most common malignant tumors in digestive system worldwide, with its mortality ranking second among all cancers. Studies have indicated that disruptions circadian rhythm (CR) are associated occurrence various cancers; however, relationship between CR and CRC requires further evidence, research on application still limited. In this study, we employed both bulk single-cell RNA sequencing to explore dysregulation patients CRC. By constructing a subtype classifier, conducted an in-depth analysis prognostic significance, status tumor microenvironment, response immune checkpoint blockade (ICB) therapy different clusters. Furthermore, developed scoring (CRS) using machine learning predict overall survival identified several genes as potential targets affecting prognosis. Our findings revealed significant alterations normal tissues transcriptome sequencing. Patients could be categorized into two distinct clusters (CR cluster 1 2). The prognosis 2, higher epithelial-mesenchymal transition (EMT) angiogenesis scores, was significantly worser than 1. These exhibited levels tumor-infiltrating lymphocytes. 2 notably proportion microsatellite-instability-high (MSI-H), potentially benefit from ICB therapy. belonging consensus molecular 4 (CMS4) also Additionally, CRS combined stage demonstrated superior prediction efficacy compared traditional stage. We link model (LSAMP, MS4A2, NAV3, RAB3B, SIX4) disruption patient This study not only provide new insights assessment but develop based CR-related genes, offering tool for personalized risk

Язык: Английский

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Clinical challenges and patient experiences in early-onset colorectal cancer: insights from seven European countries

BMC Gastroenterology, Год журнала: 2025, Номер 25(1)

Опубликована: Май 15, 2025

Язык: Английский

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Clostridium difficile as a potent trigger of colorectal carcinogenesis

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Май 24, 2025

Язык: Английский

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