Brain Behavior & Immunity - Health, Год журнала: 2025, Номер unknown, С. 101024 - 101024
Опубликована: Май 1, 2025
Язык: Английский
Diabetology & Metabolic Syndrome, Год журнала: 2025, Номер 17(1)
Опубликована: Янв. 3, 2025
Язык: Английский
Процитировано
1
Journal of Stroke and Cerebrovascular Diseases, Год журнала: 2025, Номер unknown, С. 108226 - 108226
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Frontiers in Psychiatry, Год журнала: 2025, Номер 15
Опубликована: Янв. 31, 2025
The Framingham Steatosis Index (FSI) serves as a diagnostic metric for fatty liver. While research has established link between depression and liver, the association with remains undocumented. aim of this study is to explore potential correlation FSI depression, addressing void. Our data originates from National Health Nutrition Examination Survey (NHANES) database. We employed PHQ-9 questionnaire evaluation depressive symptoms. investigated using weighted multiple logistic regression model stratified analysis. Non-linear associations were explored fitted smooth curves. A recursive method was identify inflection points. Subgroup analyses conducted examine differences in within subgroups. encompassed total 19,697 participants. Multivariate analysis, adjusted confounding factors, demonstrated significant positive OR 1.14 (95% CI: 1.10, 1.18). Stratified analysis indicated that exists among all groups except those BMI below 30. non-linear relationship further confirmed by restricted cubic splines which revealed an point at value 29.72. Below threshold, there no correlation, while above it, observed. statistically interactions educational attainment groups. study's discovery curvilinear depression. Factors such inflammation, hormonal levels, metabolic disruptions could be underlying mechanisms driving relationship. This finding offers valuable insights inform development comprehensive intervention strategies managing clinical settings.
Язык: Английский
Процитировано
0
Progress in Orthodontics, Год журнала: 2025, Номер 26(1)
Опубликована: Май 16, 2025
Abstract Background Observational studies indicate that obesity correlates with jaw development and remodeling; however, causality remains unclear. This study aimed to examine the potential causal relationship between life-course adiposity anomalies. Methods Utilizing summary statistics from genome-wide association predominantly of European ancestry, we conducted univariable multivariable Mendelian randomization (MR) estimate overall independent effects six traits (birth weight, childhood body size, mass index [BMI], adult BMI, fat percentage, waist circumference) on seven anomalies, including bimaxillary hypoplasia, prognathism, retrognathism, asymmetry. Comprehensive sensitivity analyses verified robustness, assessed heterogeneity, examined pleiotropy. Results In univariate analyses, genetically predicted thinner size (inverse variance weighted [IVW] OR: 0.41, 95% CI: 0.27–0.62, p < 0.001), BMI (IVW 0.65, 0.53–0.80, circumference 0.60, 0.45–0.82, = 0.001) were significantly associated risk mandibular retrognathia following Bonferroni correction. Multivariable MR analysis revealed a direct effect retrognathia, birth adiposity, growth hormones, lifestyle factors. No evidence was found for associations other Sensitivity produced broadly consistent findings. Conclusions provides new thin emphasizing critical role early nutrition weight management in craniofacial development.
Язык: Английский
Процитировано
0
Brain Behavior & Immunity - Health, Год журнала: 2025, Номер unknown, С. 101024 - 101024
Опубликована: Май 1, 2025
Язык: Английский
Процитировано
0