Evaluating the causal effects of life-course adiposity on jaw anomalies DOI Creative Commons
Xin Chen, Cheng Zheng, Qianyi Wang

et al.

Progress in Orthodontics, Journal Year: 2025, Volume and Issue: 26(1)

Published: May 16, 2025

Abstract Background Observational studies indicate that obesity correlates with jaw development and remodeling; however, causality remains unclear. This study aimed to examine the potential causal relationship between life-course adiposity anomalies. Methods Utilizing summary statistics from genome-wide association predominantly of European ancestry, we conducted univariable multivariable Mendelian randomization (MR) estimate overall independent effects six traits (birth weight, childhood body size, mass index [BMI], adult BMI, fat percentage, waist circumference) on seven anomalies, including bimaxillary hypoplasia, prognathism, retrognathism, asymmetry. Comprehensive sensitivity analyses verified robustness, assessed heterogeneity, examined pleiotropy. Results In univariate analyses, genetically predicted thinner size (inverse variance weighted [IVW] OR: 0.41, 95% CI: 0.27–0.62, p < 0.001), BMI (IVW 0.65, 0.53–0.80, circumference 0.60, 0.45–0.82, = 0.001) were significantly associated risk mandibular retrognathia following Bonferroni correction. Multivariable MR analysis revealed a direct effect retrognathia, birth adiposity, growth hormones, lifestyle factors. No evidence was found for associations other Sensitivity produced broadly consistent findings. Conclusions provides new thin emphasizing critical role early nutrition weight management in craniofacial development.

Language: Английский

Relationship between BMI, indicators of lipid metabolism and diabetic neuropathy: a Mendelian randomization study DOI Creative Commons

Yuanyuan Jia,

Guanying Liu,

Xuesong Li

et al.

Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 3, 2025

Language: Английский

Citations

1
3DSlicer Software-Assisted Neuroendoscopic Surgery Compared with Traditional Surgery on Surgical Effects, Complications, and Safety Evaluation in Patients with Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis DOI Creative Commons
Han Jin,

Zhitong Han,

Ruijian Zhang

et al.

Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 108226 - 108226

Published: Jan. 1, 2025

Language: Английский

Citations

0
The curvilinear relationship between Framingham Steatosis Index and depression: insights from a nationwide study DOI Creative Commons
Chunqi Jiang, Wei Wang, Ning Wang

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 31, 2025

The Framingham Steatosis Index (FSI) serves as a diagnostic metric for fatty liver. While research has established link between depression and liver, the association with remains undocumented. aim of this study is to explore potential correlation FSI depression, addressing void. Our data originates from National Health Nutrition Examination Survey (NHANES) database. We employed PHQ-9 questionnaire evaluation depressive symptoms. investigated using weighted multiple logistic regression model stratified analysis. Non-linear associations were explored fitted smooth curves. A recursive method was identify inflection points. Subgroup analyses conducted examine differences in within subgroups. encompassed total 19,697 participants. Multivariate analysis, adjusted confounding factors, demonstrated significant positive OR 1.14 (95% CI: 1.10, 1.18). Stratified analysis indicated that exists among all groups except those BMI below 30. non-linear relationship further confirmed by restricted cubic splines which revealed an point at value 29.72. Below threshold, there no correlation, while above it, observed. statistically interactions educational attainment groups. study's discovery curvilinear depression. Factors such inflammation, hormonal levels, metabolic disruptions could be underlying mechanisms driving relationship. This finding offers valuable insights inform development comprehensive intervention strategies managing clinical settings.

Language: Английский

Citations

0
Evaluating the causal effects of life-course adiposity on jaw anomalies DOI Creative Commons
Xin Chen, Cheng Zheng, Qianyi Wang

et al.

Progress in Orthodontics, Journal Year: 2025, Volume and Issue: 26(1)

Published: May 16, 2025

Abstract Background Observational studies indicate that obesity correlates with jaw development and remodeling; however, causality remains unclear. This study aimed to examine the potential causal relationship between life-course adiposity anomalies. Methods Utilizing summary statistics from genome-wide association predominantly of European ancestry, we conducted univariable multivariable Mendelian randomization (MR) estimate overall independent effects six traits (birth weight, childhood body size, mass index [BMI], adult BMI, fat percentage, waist circumference) on seven anomalies, including bimaxillary hypoplasia, prognathism, retrognathism, asymmetry. Comprehensive sensitivity analyses verified robustness, assessed heterogeneity, examined pleiotropy. Results In univariate analyses, genetically predicted thinner size (inverse variance weighted [IVW] OR: 0.41, 95% CI: 0.27–0.62, p < 0.001), BMI (IVW 0.65, 0.53–0.80, circumference 0.60, 0.45–0.82, = 0.001) were significantly associated risk mandibular retrognathia following Bonferroni correction. Multivariable MR analysis revealed a direct effect retrognathia, birth adiposity, growth hormones, lifestyle factors. No evidence was found for associations other Sensitivity produced broadly consistent findings. Conclusions provides new thin emphasizing critical role early nutrition weight management in craniofacial development.

Language: Английский

Citations

0