MYC on the Path to Cancer

Cell, Год журнала: 2012, Номер 149(1), С. 22 - 35

Опубликована: Март 1, 2012

Язык: Английский

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Transcriptional architecture of the mammalian circadian clock

Nature Reviews Genetics, Год журнала: 2016, Номер 18(3), С. 164 - 179

Опубликована: Дек. 19, 2016

Язык: Английский

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Central and Peripheral Circadian Clocks in Mammals

Annual Review of Neuroscience, Год журнала: 2012, Номер 35(1), С. 445 - 462

Опубликована: Май 20, 2012

The circadian system of mammals is composed a hierarchy oscillators that function at the cellular, tissue, and systems levels. A common molecular mechanism underlies cell-autonomous oscillator throughout body, yet this clock adapted to different functional contexts. In central suprachiasmatic nucleus (SCN) hypothalamus, coupled population neuronal acts as master pacemaker for organism drive rhythms in activity rest, feeding, body temperature, hormones. Coupling within SCN network confers robustness pacemaker, which turn provides stability overall temporal architecture organism. Throughout majority cells clocks are intimately enmeshed metabolic pathways. Thus, an emerging view adaptive significance their fundamental role orchestrating metabolism.

Язык: Английский

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Mammalian Sirtuins: Biological Insights and Disease Relevance

Annual Review of Pathology Mechanisms of Disease, Год журнала: 2010, Номер 5(1), С. 253 - 295

Опубликована: Янв. 1, 2010

Aging is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as type II diabetes mellitus, neurodegenerative diseases, cancer, cardiovascular disease. Historically, researchers have focused on investigating individual pathways isolated organs strategy identify root cause disease, with hopes designing better drugs. Studies aging yeast led discovery family conserved enzymes known sirtuins, which affect that increase life span overall health organisms. Since first mammalian sirtuin, SIRT1, 10 years ago, there been major advances our understanding enzymology their regulation, ability broadly improve physiology span. This review summarizes discusses past decade challenges will confront field coming years.

Язык: Английский

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Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet

Cell Metabolism, Год журнала: 2012, Номер 15(6), С. 848 - 860

Опубликована: Май 17, 2012

Язык: Английский

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Circadian Integration of Metabolism and Energetics

Science, Год журнала: 2010, Номер 330(6009), С. 1349 - 1354

Опубликована: Дек. 2, 2010

Circadian clocks align behavioral and biochemical processes with the day/night cycle. Nearly all vertebrate cells possess self-sustained that couple endogenous rhythms changes in cellular environment. Genetic disruption of clock genes mice perturbs metabolic functions specific tissues at distinct phases sleep/wake desynchrony, a characteristic shift work sleep humans, also leads to pathologies. Here, we review advances understanding interrelationship among circadian disruption, deprivation, obesity, diabetes implications for rational therapeutics these conditions.

Язык: Английский

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NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Cell Metabolism, Год журнала: 2015, Номер 22(1), С. 31 - 53

Опубликована: Июнь 25, 2015

Язык: Английский

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Molecular architecture of the mammalian circadian clock

Trends in Cell Biology, Год журнала: 2013, Номер 24(2), С. 90 - 99

Опубликована: Авг. 1, 2013

Язык: Английский

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NAD+ and sirtuins in aging and disease

Trends in Cell Biology, Год журнала: 2014, Номер 24(8), С. 464 - 471

Опубликована: Апрель 29, 2014

Язык: Английский

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Suprachiasmatic Nucleus: Cell Autonomy and Network Properties

Annual Review of Physiology, Год журнала: 2010, Номер 72(1), С. 551 - 577

Опубликована: Фев. 11, 2010

The suprachiasmatic nucleus (SCN) is the primary circadian pacemaker in mammals. Individual SCN neurons dispersed culture can generate independent oscillations of clock gene expression and neuronal firing. However, rhythmicity depends on sufficient membrane depolarization levels intracellular calcium cAMP. In intact SCN, cellular are synchronized reinforced by rhythmic synaptic input from other cells, resulting a reproducible topographic pattern distinct phases amplitudes specified circuit organization. network synchronizes its component oscillators, reinforces their oscillations, responds to light altering phase distribution, increases robustness genetic perturbations, enhances precision. Thus, even though individual be cell-autonomous properties integral normal function SCN.

Язык: Английский

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