Dopamine in Motivational Control: Rewarding, Aversive, and Alerting

Neuron, Год журнала: 2010, Номер 68(5), С. 815 - 834

Опубликована: Дек. 1, 2010

Язык: Английский

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Optogenetics in Neural Systems

Neuron, Год журнала: 2011, Номер 71(1), С. 9 - 34

Опубликована: Июль 1, 2011

Язык: Английский

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The Development and Application of Optogenetics

Annual Review of Neuroscience, Год журнала: 2011, Номер 34(1), С. 389 - 412

Опубликована: Март 2, 2011

Genetically encoded, single-component optogenetic tools have made a significant impact on neuroscience, enabling specific modulation of selected cells within complex neural tissues. As the toolbox contents grow and diversify, opportunities for neuroscience continue to grow. In this review, we outline development currently available summarize application various in diverse model organisms.

Язык: Английский

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The brain reward circuitry in mood disorders

Nature reviews. Neuroscience, Год журнала: 2013, Номер 14(9), С. 609 - 625

Опубликована: Авг. 14, 2013

Язык: Английский

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Modulation of Striatal Projection Systems by Dopamine

Annual Review of Neuroscience, Год журнала: 2011, Номер 34(1), С. 441 - 466

Опубликована: Март 2, 2011

The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Two striatal projection systems—so-called direct and indirect pathways—form the functional backbone circuit. Twenty years ago, investigators proposed striatum's ability to use dopamine (DA) rise fall control selection was due segregation D 1 2 DA receptors in direct- indirect-pathway spiny neurons. Although this hypothesis sparked debate, evidence has accumulated since then clearly supports model. Recent advances means marking neural circuits with optical or molecular reporters have revealed clear-cut dichotomy between these two cell types at molecular, anatomical, physiological levels. contrast provided by studies new insights into how striatum responds fluctuations signaling diseases alter change function.

Язык: Английский

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Natural Neural Projection Dynamics Underlying Social Behavior

Cell, Год журнала: 2014, Номер 157(7), С. 1535 - 1551

Опубликована: Июнь 1, 2014

Язык: Английский

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Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders

Pharmacological Reviews, Год журнала: 2012, Номер 64(2), С. 238 - 258

Опубликована: Март 8, 2012

Brain derived neurotrophic factor (BDNF) is the most prevalent growth in central nervous system (CNS). It essential for development of CNS and neuronal plasticity. Because BDNF plays a crucial role plasticity brain, it widely implicated psychiatric diseases. This review provides summary clinical preclinical evidence involvement this ubiquitous major depressive disorder, schizophrenia, addiction, Rett syndrome, as well other neurodevelopmental In addition, includes discussion mechanism action pharmacological therapies currently used to treat these diseases, such antidepressants antipsychotics. The also covers critique experimental mimetics discusses value target future drug development.

Язык: Английский

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Optogenetics: 10 years of microbial opsins in neuroscience

Nature Neuroscience, Год журнала: 2015, Номер 18(9), С. 1213 - 1225

Опубликована: Авг. 26, 2015

Язык: Английский

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Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons

Nature, Год журнала: 2012, Номер 493(7433), С. 532 - 536

Опубликована: Дек. 11, 2012

Язык: Английский

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Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling

Neuron, Год журнала: 2011, Номер 69(4), С. 650 - 663

Опубликована: Фев. 1, 2011

Язык: Английский

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