Neurobiology of addiction: a neurocircuitry analysis

The Lancet Psychiatry, Год журнала: 2016, Номер 3(8), С. 760 - 773

Опубликована: Июль 28, 2016

Язык: Английский

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Neuron-type-specific signals for reward and punishment in the ventral tegmental area

Nature, Год журнала: 2012, Номер 482(7383), С. 85 - 88

Опубликована: Янв. 18, 2012

Язык: Английский

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The Brain on Drugs: From Reward to Addiction

Cell, Год журнала: 2015, Номер 162(4), С. 712 - 725

Опубликована: Авг. 1, 2015

Язык: Английский

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Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Annual Review of Psychology, Год журнала: 2015, Номер 67(1), С. 23 - 50

Опубликована: Авг. 8, 2015

A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational use to compulsive drug-seeking habits, neurally underpinned by prefrontal cortical striatal control over seeking and taking well progression the ventral dorsal striatum. Here, in light of burgeoning, supportive evidence, reconsider elaborate this hypothesis, particular refinements our understanding mechanisms underlying goal-directed habitual seeking, influence drug-associated Pavlovian-conditioned stimuli on relapse, evidence for impairments top-down inhibitory behavior. We further review animal human studies have begun define etiological factors individual differences propensity become addicted drugs, leading description endophenotypes, especially cocaine addiction. consider prospect novel treatments promote abstinence relapse use.

Язык: Английский

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NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Depression (LTP/LTD)

Cold Spring Harbor Perspectives in Biology, Год журнала: 2012, Номер 4(6), С. a005710 - a005710

Опубликована: Апрель 17, 2012

Long-term potentiation and long-term depression (LTP/LTD) can be elicited by activating N-methyl-d-aspartate (NMDA)-type glutamate receptors, typically the coincident activity of pre- postsynaptic neurons. The early phases expression are mediated a redistribution AMPA-type receptors: More receptors added to potentiate synapse or removed weaken synapses. With time, structural changes become apparent, which in general require synthesis new proteins. investigation molecular cellular mechanisms underlying these forms synaptic plasticity has received much attention, because NMDA receptor-dependent LTP LTD may constitute substrates learning memory.

Язык: Английский

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Reward and aversion in a heterogeneous midbrain dopamine system

Neuropharmacology, Год журнала: 2013, Номер 76, С. 351 - 359

Опубликована: Апрель 8, 2013

Язык: Английский

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Optogenetic investigation of neural circuits underlying brain disease in animal models

Nature reviews. Neuroscience, Год журнала: 2012, Номер 13(4), С. 251 - 266

Опубликована: Март 20, 2012

Язык: Английский

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Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens

Neuron, Год журнала: 2012, Номер 76(4), С. 790 - 803

Опубликована: Ноя. 1, 2012

Язык: Английский

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Nociception, Pain, Negative Moods, and Behavior Selection

Neuron, Год журнала: 2015, Номер 87(3), С. 474 - 491

Опубликована: Авг. 1, 2015

Язык: Английский

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GABA Neurons of the VTA Drive Conditioned Place Aversion

Neuron, Год журнала: 2012, Номер 73(6), С. 1173 - 1183

Опубликована: Март 1, 2012

Язык: Английский

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