Proceedings of the National Academy of Sciences,
Год журнала:
2014,
Номер
111(47), С. 16647 - 16653
Опубликована: Ноя. 17, 2014
Although
major
research
efforts
have
focused
on
how
specific
components
of
foodstuffs
affect
health,
relatively
little
is
known
about
a
more
fundamental
aspect
diet,
the
frequency
and
circadian
timing
meals,
potential
benefits
intermittent
periods
with
no
or
very
low
energy
intakes.
The
most
common
eating
pattern
in
modern
societies,
three
meals
plus
snacks
every
day,
abnormal
from
an
evolutionary
perspective.
Emerging
findings
studies
animal
models
human
subjects
suggest
that
restriction
as
16
h
can
improve
health
indicators
counteract
disease
processes.
mechanisms
involve
metabolic
shift
to
fat
metabolism
ketone
production,
stimulation
adaptive
cellular
stress
responses
prevent
repair
molecular
damage.
As
data
optimal
crystalizes,
it
will
be
critical
develop
strategies
incorporate
those
patterns
into
care
policy
practice,
lifestyles
population.
Proceedings of the National Academy of Sciences,
Год журнала:
2013,
Номер
110(14), С. 5695 - 5700
Опубликована: Март 11, 2013
Insufficient
sleep
is
associated
with
obesity,
yet
little
known
about
how
repeated
nights
of
insufficient
influence
energy
expenditure
and
balance.
We
studied
16
adults
in
a
14-
to
15-d-long
inpatient
study
quantified
effects
5
d
sleep,
equivalent
work
week,
on
intake
compared
adequate
sleep.
found
that
increased
total
daily
by
∼5%;
however,
intake--especially
at
night
after
dinner--was
excess
needed
maintain
led
0.82
±
0.47
kg
(±SD)
weight
gain
despite
changes
hunger
satiety
hormones
ghrelin
leptin,
peptide
YY,
which
signaled
stores.
delayed
circadian
melatonin
phase
also
an
earlier
wake
time.
Sex
differences
showed
women,
not
men,
maintained
during
whereas
reduced
dietary
restraint
women.
Our
findings
suggest
food
physiological
adaptation
provide
sustain
additional
wakefulness;
when
easily
accessible,
surpasses
needed.
transitioning
from
adequate/recovery
schedule
decreased
intake,
especially
fats
carbohydrates,
-0.03
0.50
loss.
These
evidence
plays
key
role
metabolism.
Importantly,
they
demonstrate
behavioral
mechanisms
may
contribute
overweight
obesity.
Science,
Год журнала:
2016,
Номер
354(6315), С. 1004 - 1008
Опубликована: Ноя. 24, 2016
Disruptions
of
normal
circadian
rhythms
and
sleep
cycles
are
consequences
aging
can
profoundly
affect
health.
Accumulating
evidence
indicates
that
disturbances,
which
have
long
been
considered
symptoms
many
neurodegenerative
conditions,
may
actually
drive
pathogenesis
early
in
the
course
these
diseases.
In
this
Review,
we
explore
potential
cellular
molecular
mechanisms
linking
dysfunction
loss
to
diseases,
with
a
focus
on
Alzheimer’s
disease.
We
examine
interplay
between
central
peripheral
rhythms,
clock
gene
function,
maintaining
brain
homeostasis,
discuss
therapeutic
implications.
The
influence
number
key
processes
involved
neurodegeneration,
suggesting
systems
might
be
manipulated
promote
healthy
aging.
Annual Review of Nutrition,
Год журнала:
2017,
Номер
37(1), С. 371 - 393
Опубликована: Июль 18, 2017
The
objective
of
this
review
is
to
provide
an
overview
intermittent
fasting
regimens,
summarize
the
evidence
on
health
benefits
fasting,
and
discuss
physiological
mechanisms
by
which
might
lead
improved
outcomes.
A
MEDLINE
search
was
performed
using
PubMed
terms
"intermittent
fasting,"
"fasting,"
"time-restricted
feeding,"
"food
timing."
Modified
regimens
appear
promote
weight
loss
may
improve
metabolic
health.
Several
lines
also
support
hypothesis
that
eating
patterns
reduce
or
eliminate
nighttime
prolong
nightly
intervals
result
in
sustained
improvements
human
Intermittent
are
hypothesized
influence
regulation
via
effects
(a)
circadian
biology,
(b)
gut
microbiome,
(c)
modifiable
lifestyle
behaviors,
such
as
sleep.
If
proven
be
efficacious,
these
offer
promising
nonpharmacological
approaches
improving
at
population
level,
with
multiple
public
benefits.
Journal of Clinical Investigation,
Год журнала:
2011,
Номер
121(6), С. 2133 - 2141
Опубликована: Июнь 1, 2011
The
discovery
of
the
genetic
basis
for
circadian
rhythms
has
expanded
our
knowledge
temporal
organization
behavior
and
physiology.
observations
that
gene
network
is
present
in
most
living
organisms
from
eubacteria
to
humans,
cells
tissues
express
autonomous
clocks,
disruption
clock
genes
results
metabolic
dysregulation
have
revealed
interactions
between
metabolism
at
neural,
molecular,
cellular
levels.
A
major
challenge
remains
understanding
interplay
brain
peripheral
clocks
determining
how
these
promote
energy
homeostasis
across
sleep-wake
cycle.
In
this
Review,
we
evaluate
investigation
molecular
timing
may
create
new
opportunities
understand
develop
therapies
obesity
diabetes.
Science,
Год журнала:
2013,
Номер
341(6153), С. 1483 - 1488
Опубликована: Авг. 23, 2013
Circadian
clocks
have
evolved
to
regulate
physiologic
and
behavioral
rhythms
in
anticipation
of
changes
the
environment.
Although
molecular
clock
is
present
innate
immune
cells,
its
role
monocyte
homeostasis
remains
unknown.
Here,
we
report
that
Ly6C(hi)
inflammatory
monocytes
exhibit
diurnal
variation,
which
controls
their
trafficking
sites
inflammation.
This
cyclic
pattern
confers
protection
against
Listeria
monocytogenes
regulated
by
repressive
activity
circadian
gene
Bmal1.
Accordingly,
myeloid
cell-specific
deletion
Bmal1
induces
expression
monocyte-attracting
chemokines
disrupts
rhythmic
cycling
monocytes,
predisposing
mice
development
pathologies
associated
with
acute
chronic
These
findings
unveiled
a
critical
for
BMAL1
controlling
numbers.
