Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Cell Death and Differentiation, Год журнала: 2018, Номер 25(3), С. 486 - 541

Опубликована: Янв. 23, 2018

Over the past decade, Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for definition and interpretation of cell death from morphological, biochemical, functional perspectives. Since field continues to expand novel mechanisms that orchestrate multiple pathways are unveiled, we propose an updated classification subroutines focusing mechanistic essential (as opposed correlative dispensable) aspects process. As provide molecularly oriented definitions terms including intrinsic apoptosis, extrinsic mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic death, NETotic lysosome-dependent autophagy-dependent immunogenic cellular senescence, mitotic catastrophe, discuss utility neologisms refer highly specialized instances these processes. The mission NCCD is a widely accepted nomenclature in support continued development field.

Язык: Английский

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Neutrophil recruitment and function in health and inflammation

Nature reviews. Immunology, Год журнала: 2013, Номер 13(3), С. 159 - 175

Опубликована: Фев. 25, 2013

Язык: Английский

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Ischemia and reperfusion—from mechanism to translation

Nature Medicine, Год журнала: 2011, Номер 17(11), С. 1391 - 1401

Опубликована: Ноя. 1, 2011

Язык: Английский

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Neutrophils in the activation and regulation of innate and adaptive immunity

Nature reviews. Immunology, Год журнала: 2011, Номер 11(8), С. 519 - 531

Опубликована: Июль 25, 2011

Язык: Английский

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Cell Biology of Ischemia/Reperfusion Injury

International review of cell and molecular biology, Год журнала: 2012, Номер unknown, С. 229 - 317

Опубликована: Янв. 1, 2012

Язык: Английский

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Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

Annual Review of Immunology, Год журнала: 2014, Номер 32(1), С. 659 - 702

Опубликована: Март 21, 2014

Chemokines are chemotactic cytokines that control the migratory patterns and positioning of all immune cells. Although chemokines were initially appreciated as important mediators acute inflammation, we now know this complex system approximately 50 endogenous chemokine ligands 20 G protein–coupled seven-transmembrane signaling receptors is also critical for generation primary secondary adaptive cellular humoral responses. Recent studies demonstrate roles in priming naive T cells, cell fate decisions such effector memory differentiation, regulatory function. In review, focus on recent advances understanding how orchestrates migration at organismic level homeostasis, during regulation adoptive responses lymphoid peripheral nonlymphoid tissue.

Язык: Английский

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Mitochondria in innate immune responses

Nature reviews. Immunology, Год журнала: 2011, Номер 11(6), С. 389 - 402

Опубликована: Май 20, 2011

Язык: Английский

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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

Archives of Toxicology, Год журнала: 2013, Номер 87(8), С. 1315 - 1530

Опубликована: Авг. 1, 2013

This review encompasses the most important advances in liver functions and hepatotoxicity analyzes which mechanisms can be studied vitro. In a complex architecture of nested, zonated lobules, consists approximately 80 % hepatocytes 20 non-parenchymal cells, latter being involved secondary phase that may dramatically aggravate initial damage. Hepatotoxicity, as well hepatic metabolism, is controlled by set nuclear receptors (including PXR, CAR, HNF-4α, FXR, LXR, SHP, VDR PPAR) signaling pathways. When isolating some pathways are activated, e.g., RAS/MEK/ERK pathway, whereas others silenced (e.g. HNF-4α), resulting up- downregulation hundreds genes. An understanding these changes crucial for correct interpretation vitro data. The possibilities limitations useful systems summarized, including three-dimensional culture techniques, co-cultures with hepatospheres, precision cut slices isolated perfused liver. Also discussed how closely hepatoma, stem cell iPS cell-derived hepatocyte-like-cells resemble real hepatocytes. Finally, summary given state art mathematical modeling currently used pharmaceutical industry an emphasis on drug prediction clearance, interaction, transporter studies hepatotoxicity. One key message despite our enthusiasm systems, we must never lose sight vivo situation. Although have been decades, hunt relevant alternative has only just begun.

Язык: Английский

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The Multifaceted Functions of Neutrophils

Annual Review of Pathology Mechanisms of Disease, Год журнала: 2013, Номер 9(1), С. 181 - 218

Опубликована: Сен. 20, 2013

Neutrophils and neutrophil-like cells are the major pathogen-fighting immune in organisms ranging from slime molds to mammals. Central their function is ability be recruited sites of infection, recognize phagocytose microbes, then kill pathogens through a combination cytotoxic mechanisms. These include production reactive oxygen species, release antimicrobial peptides, recently discovered expulsion nuclear contents form neutrophil extracellular traps. Here we discuss these primordial functions, which also play key roles tissue injury, by providing details functions congenital disorders neutrophils. In addition, present more recent evidence that interactions between neutrophils adaptive establish feed-forward mechanism amplifies pathologic inflammation. newly appreciated contributions described setting several inflammatory autoimmune diseases.

Язык: Английский

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Liver macrophages in tissue homeostasis and disease

Nature reviews. Immunology, Год журнала: 2017, Номер 17(5), С. 306 - 321

Опубликована: Март 20, 2017

Язык: Английский

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