Nature Reviews Endocrinology, Год журнала: 2013, Номер 9(3), С. 144 - 152
Опубликована: Янв. 22, 2013
Язык: Английский
Nature Reviews Endocrinology, Год журнала: 2013, Номер 9(3), С. 144 - 152
Опубликована: Янв. 22, 2013
Язык: Английский
Comprehensive physiology, Год журнала: 2013, Номер unknown, С. 1191 - 1212
Опубликована: Июль 1, 2013
Bile acids are important physiological agents for intestinal nutrient absorption and biliary secretion of lipids, toxic metabolites, xenobiotics. also signaling molecules metabolic regulators that activate nuclear receptors G protein-coupled receptor (GPCR) to regulate hepatic lipid, glucose, energy homeostasis maintain homeostasis. Conversion cholesterol bile is critical maintaining preventing accumulation cholesterol, triglycerides, injury in the liver other organs. Enterohepatic circulation from intestine back plays a central role distribution, regulation This process regulated by complex membrane transport system receptors. Toxic may cause inflammation, apoptosis, cell death. On hand, acid-activated GPCR protects against inflammation liver, intestine, macrophages. Disorders acid metabolism cholestatic diseases, dyslipidemia, fatty cardiovascular diabetes. acids, derivatives, sequestrants therapeutic treating chronic obesity, diabetes humans. © 2013 American Physiological Society. Compr Physiol 3:1191-1212, 2013.
Язык: Английский
Процитировано
1291Nature, Год журнала: 2014, Номер 510(7503), С. 84 - 91
Опубликована: Июнь 1, 2014
Язык: Английский
Процитировано
1019Cell Metabolism, Год журнала: 2012, Номер 15(3), С. 279 - 291
Опубликована: Март 1, 2012
Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets. Recent discoveries essential lipolytic enzymes and characterization numerous regulatory proteins mechanisms have fundamentally changed our perception lipolysis its impact on metabolism. New findings that products intermediates participate signaling processes "lipolytic signaling" particularly important many nonadipose tissues unveil a previously underappreciated aspect lipolysis, which may be relevant for human disease.
Язык: Английский
Процитировано
1000Cell Metabolism, Год журнала: 2016, Номер 23(5), С. 770 - 784
Опубликована: Май 1, 2016
Язык: Английский
Процитировано
896Journal of Gastroenterology, Год журнала: 2013, Номер 48(4), С. 434 - 441
Опубликована: Фев. 9, 2013
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation in the absence of excess alcohol intake. NAFLD most common chronic disease, and ongoing research efforts are focused on understanding underlying pathobiology steatosis with anticipation that these will identify novel therapeutic targets. Under physiological conditions, low steady-state triglyceride concentrations attributable to a precise balance between acquisition uptake non-esterified acids from plasma de novo lipogenesis, versus disposal acid oxidation secretion triglyceride-rich lipoproteins. In patients, insulin resistance leads multiple mechanisms. Greater rates increased release an expanded mass adipose tissue as consequence diminished responsiveness. Hyperinsulinemia promotes transcriptional upregulation genes promote lipogenesis liver. Increased not offset or This review discusses molecular mechanisms which homeostasis achieved under normal well metabolic alterations occur setting contribute pathogenesis NAFLD.
Язык: Английский
Процитировано
849Pharmacological Reviews, Год журнала: 2014, Номер 66(4), С. 948 - 983
Опубликована: Июль 29, 2014
Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis accounts for a major fraction daily turnover in humans. Biliary secretion generates flow and facilitates hepatobiliary lipids, lipophilic metabolites, xenobiotics. In intestine, essential absorption, transport, metabolism dietary fats lipid-soluble vitamins. Extensive research last 2 decades has unveiled new functions as signaling molecules metabolic integrators. The acid-activated nuclear receptors farnesoid X receptor, pregnane constitutive androstane vitamin D G protein-coupled receptor play critical roles regulation lipid, glucose, energy metabolism, inflammation, drug detoxification. exhibits strong diurnal rhythm, which is entrained by fasting refeeding well nutrient status plays an important role maintaining homeostasis. Recent revealed interaction liver gut microbiota metabolism. Circadian disturbance altered contribute to pathogenesis diseases, inflammatory bowel nonalcoholic fatty disease, diabetes, obesity. their derivatives potential therapeutic agents treating diseases liver.
Язык: Английский
Процитировано
804Nature Reviews Endocrinology, Год журнала: 2012, Номер 8(12), С. 743 - 754
Опубликована: Ноя. 21, 2012
Язык: Английский
Процитировано
802Gastroenterology, Год журнала: 2014, Номер 147(4), С. 765 - 783.e4
Опубликована: Июль 18, 2014
Язык: Английский
Процитировано
687Cancer Communications, Год журнала: 2018, Номер 38(1), С. 1 - 14
Опубликована: Май 21, 2018
Abstract Reprogramming of lipid metabolism is a newly recognized hallmark malignancy. Increased uptake, storage and lipogenesis occur in variety cancers contribute to rapid tumor growth. Lipids constitute the basic structure membranes also function as signaling molecules energy sources. Sterol regulatory element‐binding proteins (SREBPs), family membrane‐bound transcription factors endoplasmic reticulum, play central role regulation metabolism. Recent studies have revealed that SREBPs are highly up‐regulated various promote SREBP cleavage‐activating protein key transporter trafficking activation well critical glucose sensor, thus linking de novo synthesis. Targeting altered metabolic pathways has become promising anti‐cancer strategy. This review summarizes recent progress our understanding malignancy, highlights potential molecular targets their inhibitors for cancer treatment.
Язык: Английский
Процитировано
686Hepatology, Год журнала: 2013, Номер 59(2), С. 713 - 723
Опубликована: Авг. 8, 2013
Nonalcoholic fatty liver disease (NAFLD), hepatic insulin resistance, and type 2 diabetes are all strongly associated reaching epidemic proportions. Whether there is a causal link between NAFLD resistance controversial. This review will discuss recent studies in both humans animal models of that have implicated increases diacylglycerol (DAG) content leading to activation novel protein kinase Cϵ (PKCϵ) resulting decreased signaling the pathogenesis NAFLD-associated diabetes. The DAG-PKCϵ hypothesis can explain occurrence observed most cases with obesity, lipodystrophy,
Язык: Английский
Процитировано
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