Cell,
Год журнала:
2021,
Номер
184(6), С. 1500 - 1516
Опубликована: Март 1, 2021
Social
homeostasis
is
the
ability
of
individuals
to
detect
quantity
and
quality
social
contact,
compare
it
an
established
set-point
in
a
command
center,
adjust
effort
expended
seek
optimal
contact
expressed
via
effector
system.
becomes
positive
or
negative
valence
stimulus
when
deficient
excess,
respectively.
Chronic
deficits
lead
adaptations
such
that
reintroduction
previous
optimum
experienced
as
surplus.
Here,
we
build
upon
models
for
include
lasting
changes
environmental
conditions,
with
chronic
isolation.
The
neurobiological
mechanisms
underlying
the
induction
and
remission
of
depressive
episodes
over
time
are
not
well
understood.
Through
repeated
longitudinal
imaging
medial
prefrontal
microcircuits
in
living
brain,
we
found
that
spinogenesis
plays
a
critical
role
sustaining
specific
antidepressant
behavioral
effects
maintaining
long-term
remission.
Depression-related
behavior
was
associated
with
targeted,
branch-specific
elimination
postsynaptic
dendritic
spines
on
projection
neurons.
Antidepressant-dose
ketamine
reversed
these
by
selectively
rescuing
eliminated
restoring
coordinated
activity
multicellular
ensembles
predict
motivated
escape
behavior.
Prefrontal
required
for
maintenance
but
their
initial
induction.
Neuron,
Год журнала:
2016,
Номер
90(4), С. 692 - 707
Опубликована: Май 1, 2016
Highlights•The
anterior
cingulate
gyrus
(ACCg)
mainly
signals
other-oriented
information•The
ACCg
responds
to
others'
motivation
and
prediction
errors•ACCg
variability
may
lead
in
social
cognition
health
disease•A
computational
framework
is
proposed
accounting
for
responsesAbstractThe
cortex
(ACC)
implicated
a
broad
range
of
behaviors
cognitive
processes,
but
it
has
been
unclear
what
contribution,
if
any,
the
ACC
makes
behavior.
We
argue
that
anatomical
functional
evidence
suggests
specific
sub-region
ACC—in
(ACCg)—plays
crucial
role
processing
information.
propose
properties
support
contribution
by
estimating
how
motivated
other
individuals
are
dynamically
updating
those
estimates
when
further
they
have
erroneous.
Notably
this
model,
based
on
vicarious
error
processing,
provides
unified
account
neurophysiological
neuroimaging
sensitive
costs,
benefits,
errors
during
interactions.
Furthermore,
specific,
testable
predictions
about
key
mechanism
underpin
socio-cognitive
abilities
disease.
Frontiers in Psychology,
Год журнала:
2015,
Номер
6
Опубликована: Ноя. 26, 2015
Social
cognition
is
a
complex
process
that
requires
the
integration
of
wide
variety
behaviors,
including
salience,
reward-seeking,
motivation,
knowledge
self
and
others,
flexibly
adjusting
behavior
in
social
groups.
Not
surprisingly,
represents
sensitive
domain
commonly
disrupted
pathology
psychiatric
disorders
Autism
Spectrum
Disorder
(ASD)
Schizophrenia
(SCZ).
Here,
we
discuss
convergent
research
from
animal
models
to
human
disease
implicates
prefrontal
cortex
(PFC)
as
key
regulator
cognition,
suggesting
disruptions
microcircuitry
play
an
essential
role
pathophysiology
with
shared
deficits.
We
take
translational
perspective
review
three
behaviors
are
normal
processing
rodents
humans,
recognition,
dominance
hierarchy.
A
circuitry
may
underlie
these
behaviors.
deficits
neurodevelopmental
like
ASD
SCZ
have
been
linked
altered
balance
excitation
inhibition
(E/I
ratio)
within
generally,
PFC
specifically.
clear
picture
mechanisms
by
which
E/I
ratio
might
lead
across
not
well
understood.
Future
studies
should
explore
how
developmental
trajectory
could
subsequent
Cell,
Год журнала:
2016,
Номер
164(4), С. 617 - 631
Опубликована: Фев. 1, 2016
The
motivation
to
seek
social
contact
may
arise
from
either
positive
or
negative
emotional
states,
as
interaction
can
be
rewarding
and
isolation
aversive.
While
ventral
tegmental
area
(VTA)
dopamine
(DA)
neurons
mediate
reward,
a
cellular
substrate
for
the
affective
state
of
loneliness
has
remained
elusive.
Here,
we
identify
functional
role
DA
in
dorsal
raphe
nucleus
(DRN),
which
observe
synaptic
changes
following
acute
isolation.
DRN
show
increased
activity
upon
isolation,
revealed
by
vivo
calcium
imaging.
Optogenetic
activation
increases
preference
but
causes
place
avoidance.
Furthermore,
these
are
necessary
promoting
rebound
sociability
an
period
Finally,
degree
modulate
behavior
is
predicted
rank,
together
supporting
mediating
loneliness-like
state.
PAPERCLIP.
Science,
Год журнала:
2017,
Номер
357(6347), С. 162 - 168
Опубликована: Июль 14, 2017
The
brain
circuits
of
a
winner
Social
dominance
in
mice
depends
on
their
history
winning
social
contests.
Zhou
et
al.
found
that
this
effect
is
mediated
by
neuronal
projections
from
the
thalamus
to
region
called
dorsomedial
prefrontal
cortex.
Selective
manipulation
synapses
driven
input
revealed
causal
relationship
between
circuit
activity
and
mental
effort–based
behavior.
Thus,
pathway
store
memory
previous
or
losing
history.
Science
,
issue
p.
162
