Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On

Annual Review of Psychology, Год журнала: 2015, Номер 67(1), С. 23 - 50

Опубликована: Авг. 8, 2015

A decade ago, we hypothesized that drug addiction can be viewed as a transition from voluntary, recreational use to compulsive drug-seeking habits, neurally underpinned by prefrontal cortical striatal control over seeking and taking well progression the ventral dorsal striatum. Here, in light of burgeoning, supportive evidence, reconsider elaborate this hypothesis, particular refinements our understanding mechanisms underlying goal-directed habitual seeking, influence drug-associated Pavlovian-conditioned stimuli on relapse, evidence for impairments top-down inhibitory behavior. We further review animal human studies have begun define etiological factors individual differences propensity become addicted drugs, leading description endophenotypes, especially cocaine addiction. consider prospect novel treatments promote abstinence relapse use.

Язык: Английский

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Coming to terms with fear

Proceedings of the National Academy of Sciences, Год журнала: 2014, Номер 111(8), С. 2871 - 2878

Опубликована: Фев. 5, 2014

Significance Research on Pavlovian fear conditioning has been very successful in revealing what come to be called the brain’s system. The field now matured point where a sharper conceptualization of is being studied could useful as we go forward. Terms like “fear conditioning” and system” blur distinction between processes that give rise conscious feelings nonconscious control defense responses elicited by threats. These interact but are not same. Using terms respect will help focus future animal research brain circuits detect respond threats, should also clarify implications this work for understanding how normal pathological about human brain.

Язык: Английский

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An Update on Memory Reconsolidation Updating

Trends in Cognitive Sciences, Год журнала: 2017, Номер 21(7), С. 531 - 545

Опубликована: Май 8, 2017

Язык: Английский

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“Eating addiction”, rather than “food addiction”, better captures addictive-like eating behavior

Neuroscience & Biobehavioral Reviews, Год журнала: 2014, Номер 47, С. 295 - 306

Опубликована: Сен. 6, 2014

"Food addiction" has become a focus of interest for researchers attempting to explain certain processes and/or behaviors that may contribute the development obesity. Although scientific discussion on "food is in its nascent stage, it potentially important implications treatment and prevention strategies. As such, critically reflect appropriateness term addiction", which combines concepts "substance-based" behavioral addiction. The currently available evidence substance-based food addiction poor, partly because systematic clinical translational studies are still at an early stage. We do however view both animal existing human data as consistent with existence addictive eating behavior. Accordingly, we stress similar other can thus predisposed individuals under specific environmental circumstances. Here, introduce current diagnostic neurobiological substance-related non-substance-related disorders, highlight similarities dissimilarities between overeating. conclude misnomer ambiguous connotation phenomenon. instead propose "eating underscore eating; future research should attempt define criteria addiction, DSM-5 now offers umbrella via introduction Non-Substance-Related Disorders within category Substance-Related Addictive Disorders.

Язык: Английский

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The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research

Psychopharmacology, Год журнала: 2013, Номер 229(3), С. 453 - 476

Опубликована: Май 17, 2013

Язык: Английский

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Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories

Cell, Год журнала: 2014, Номер 156(1-2), С. 261 - 276

Опубликована: Янв. 1, 2014

Язык: Английский

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In vivo imaging identifies temporal signature of D1 and D2 medium spiny neurons in cocaine reward

Proceedings of the National Academy of Sciences, Год журнала: 2016, Номер 113(10), С. 2726 - 2731

Опубликована: Фев. 1, 2016

Significance Strong associations between cocaine and the environmental contexts where is administered are thought to drive relapse. The nucleus accumbens (NAc) encodes these cue–reward associations, here we determined how alters ability of cells in NAc respond drug-associated stimuli drug seeking. Using fiber photometry calcium imaging define specific population cells, dopamine D1 receptor-expressing neurons, that information about show can be manipulated attenuate strength prevent Together, data a basic circuit mechanism underlying drug–context suggest pharmacotherapeutic agents aimed at D1-type neurons may help promote sustained abstinence abusers.

Язык: Английский

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Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories – indications for novel treatments of addiction

European Journal of Neuroscience, Год журнала: 2014, Номер 40(1), С. 2163 - 2182

Опубликована: Июнь 17, 2014

Abstract This review discusses the evidence for hypothesis that development of drug addiction can be understood in terms interactions between Pavlovian and instrumental learning memory mechanisms brain underlie seeking taking drugs. It is argued these behaviours initially are goal‐directed, but increasingly become elicited as stimulus–response habits by drug‐associated conditioned stimuli established conditioning. further compulsive use emerges result a loss prefrontal cortical inhibitory control over habits. Data reviewed indicate transitions from to abuse depend upon shifts ventral dorsal striatal behaviour, mediated part serial connectivity striatum midbrain dopamine systems. Only some individuals lose their use, importance behavioural impulsivity vulnerability trait predicting stimulant animals humans, together with consideration an emerging neuroendophenotype discussed. Finally, potential developing treatments considered light neuropsychological advances reviewed, including possibility targeting reconsolidation extinction reduce influences on means promoting abstinence preventing relapse.

Язык: Английский

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Rethinking Extinction

Neuron, Год журнала: 2015, Номер 88(1), С. 47 - 63

Опубликована: Окт. 1, 2015

Язык: Английский

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Extinction during reconsolidation of threat memory diminishes prefrontal cortex involvement

Proceedings of the National Academy of Sciences, Год журнала: 2013, Номер 110(50), С. 20040 - 20045

Опубликована: Ноя. 25, 2013

Significance An advantage of targeting reconsolidation to control reactions learned threats is that the memory appears be persistently altered, not inhibited. When these memories are diminished through extinction, amygdala’s representation remains largely intact and prefrontal cortex inhibits its expression, thus allowing responses recover. Targeting reconsolidation, therefore, should eliminate necessity inhibition. We tested this hypothesis by contrasting standard extinction with occurring during reconsolidation. observed behavioral interference bypass circuitry inducing a more persistent loss responses. Application strategy, which targets underlying threat processes, fear anxiety disorders may provide effective approach treatment.

Язык: Английский

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