Ultraflexible nanoelectronic probes form reliable, glial scar–free neural integration

Science Advances, Год журнала: 2017, Номер 3(2)

Опубликована: Фев. 3, 2017

Implanted brain electrodes construct the only means to electrically interface with individual neurons in vivo, but their recording efficacy and biocompatibility pose limitations on scientific clinical applications. We showed that nanoelectronic thread (NET) subcellular dimensions, ultraflexibility, cellular surgical footprints form reliable, glial scar-free neural integration. demonstrated NET reliably detected tracked units for months; impedance, noise level, single-unit yield, signal amplitude remained stable during long-term implantation. In vivo two-photon imaging postmortem histological analysis revealed seamless, integration of probes local vasculature networks, featuring fully recovered capillaries an intact blood-brain barrier complete absence chronic neuronal degradation scar.

Язык: Английский

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Glial responses to implanted electrodes in the brain

Nature Biomedical Engineering, Год журнала: 2017, Номер 1(11), С. 862 - 877

Опубликована: Ноя. 3, 2017

Язык: Английский

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Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging

Nature Communications, Год журнала: 2014, Номер 5(1)

Опубликована: Окт. 20, 2014

Язык: Английский

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Flexible and Stretchable Smart Display: Materials, Fabrication, Device Design, and System Integration

Advanced Functional Materials, Год журнала: 2018, Номер 28(35)

Опубликована: Июль 5, 2018

Abstract Recent technological advances in nanomaterials have driven the development of high‐performance light‐emitting devices with flexible and stretchable form factors. Deformability such is mainly achieved by replacing rigid materials device components their assemblies (e.g., carbon nanotubes, silver nanowires, graphene, quantum dots) or intrinsically soft composites polymers elastomers). Downscaling dimensions functional to nanometer range dramatically decreases flexural rigidity, production polymer/elastomer provides flexibility stretchability. Furthermore, monolithic integration these deformable sensors furnishes resulting display various smart functions as force/capacitive touch‐based data input, personalized health monitoring, interactive human–machine interfacing. These ultrathin, lightweight, optoelectronic attracted widespread interest from scientists engineers. Here, a comprehensive review recent progress concerning displays presented focus on development, fabrication techniques, designs. Brief overviews an integrated system advanced cutting‐edge wearable are also presented, and, conclude, discussion future research outlook given.

Язык: Английский

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Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics

Cell, Год журнала: 2015, Номер 162(3), С. 662 - 674

Опубликована: Июль 1, 2015

Язык: Английский

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