Journal of Medical Internet Research,
Год журнала:
2019,
Номер
21(10), С. e16194 - e16194
Опубликована: Окт. 14, 2019
Brain-machine
interfaces
hold
promise
for
the
restoration
of
sensory
and
motor
function
treatment
neurological
disorders,
but
clinical
brain-machine
have
not
yet
been
widely
adopted,
in
part,
because
modest
channel
counts
limited
their
potential.
In
this
white
paper,
we
describe
Neuralink's
first
steps
toward
a
scalable
high-bandwidth
interface
system.
We
built
arrays
small
flexible
electrode
"threads,"
with
as
many
3072
electrodes
per
array
distributed
across
96
threads.
also
neurosurgical
robot
capable
inserting
six
threads
(192
electrodes)
minute.
Each
thread
can
be
individually
inserted
into
brain
micron
precision
avoidance
surface
vasculature
targeting
specific
regions.
The
is
packaged
implantable
device
that
contains
custom
chips
low-power
on-board
amplification
digitization:
package
channels
occupies
less
than
23×18.5×2
mm
Measuring
the
dynamics
of
neural
processing
across
time
scales
requires
following
spiking
thousands
individual
neurons
over
milliseconds
and
months.
To
address
this
need,
we
introduce
Neuropixels
2.0
probe
together
with
newly
designed
analysis
algorithms.
The
has
more
than
5000
sites
is
miniaturized
to
facilitate
chronic
implants
in
small
mammals
recording
during
unrestrained
behavior.
High-quality
recordings
long
were
reliably
obtained
mice
rats
six
laboratories.
Improved
site
density
arrangement
combined
created
data
methods
enable
automatic
post
hoc
correction
for
brain
movements,
allowing
from
same
2
These
probes
algorithms
stable
free
behavior,
even
animals
such
as
mice.
Advanced Functional Materials,
Год журнала:
2017,
Номер
28(12)
Опубликована: Июль 19, 2017
Abstract
Advancements
in
neurotechnologies
for
electrophysiology,
neurochemical
sensing,
neuromodulation,
and
optogenetics
are
revolutionizing
scientific
understanding
of
the
brain
while
enabling
treatments
preventative
measures
a
variety
neurological
disorders.
The
grand
challenge
neural
interface
engineering
is
to
seamlessly
integrate
between
neurobiology
engineered
technology
record
from
modulate
neurons
over
chronic
timescales.
However,
biological
inflammatory
response
implants,
degeneration,
long‐term
material
stability
diminishes
quality
overtime.
Recent
advances
functional
materials
aimed
at
solutions
interfaces,
yet,
development
deployment
interfaces
designed
novel
have
introduced
new
challenges
that
been
largely
unaddressed.
Many
efforts
solely
focus
on
optimizing
individual
probe
design
parameters,
such
as
softness
or
flexibility,
downplay
critical
multidimensional
interactions
different
physical
properties
device
contribute
overall
performance
biocompatibility.
Moreover,
use
these
present
substantial
difficulties
must
be
addressed
before
regulatory
approval
human
patients
achievable.
In
this
review,
interdependence
electrode
components
highlighted
demonstrate
current
material‐based
facing
field
engineering.
