Role of Lactobacillus reuteri in Human Health and Diseases

Frontiers in Microbiology, Год журнала: 2018, Номер 9

Опубликована: Апрель 19, 2018

Lactobacillus reuteri (L. reuteri) is a well-studied probiotic bacterium that can colonize large number of mammals. In humans, L. found in different body sites, including the gastrointestinal tract, urinary skin, and breast milk. The abundance varies among individuals. Several beneficial effects have been noted. First, produce antimicrobial molecules, such as organic acids, ethanol, reuterin. Due to its activity, able inhibit colonization pathogenic microbes remodel commensal microbiota composition host. Second, benefit host immune system. For instance, some strains reduce production pro-inflammatory cytokines while promoting regulatory T cell development function. Third, bearing ability strengthen intestinal barrier, may decrease microbial translocation from gut lumen tissues. Microbial across epithelium has hypothesized an initiator inflammation. Therefore, inflammatory diseases, those located well remote tissues, be ameliorated by increasing reuteri. Notably, humans past decades correlated with increase incidences diseases over same period time. Direct supplementation or prebiotic modulation attractive preventive and/or therapeutic avenue against diseases.

Язык: Английский

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Intestinal Microbiota Is Influenced by Gender and Body Mass Index

PLoS ONE, Год журнала: 2016, Номер 11(5), С. e0154090 - e0154090

Опубликована: Май 26, 2016

Intestinal microbiota changes are associated with the development of obesity. However, studies in humans have generated conflicting results due to high inter-individual heterogeneity terms diet, age, and hormonal factors, largely unexplored influence gender. In this work, we aimed identify differential gut signatures obesity, as a function gender body mass index (BMI). Differences bacterial community structure were analyzed by 16S sequencing 39 men 36 post-menopausal women, who had similar dietary background, matched age stratified according BMI. We observed that abundance Bacteroides genus was lower than women (P<0.001, Q = 0.002) when BMI > 33. fact, decreased an increase Q<0.001). it remained unchanged within different ranges higher presence Veillonella (84.6% vs. 47.2%; X2 test P 0.001, 0.019) Methanobrevibacter genera 0.002, 0.026) fecal samples compared women. also Bilophila regardless (P 0.041). Additionally, after correcting for sex, 66 taxa at level found be plasma lipids. Microbiota explained 31.17% variation BMI, 29.04% triglycerides, 33.70% high-density lipoproteins, 46.86% low-density 28.55% total cholesterol. Our suggest may differ between these differences influenced grade The divergence might dominant role definition prevalence metabolic intestinal inflammatory diseases.

Язык: Английский

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Intestinal Dysbiosis Associated with Systemic Lupus Erythematosus

mBio, Год журнала: 2014, Номер 5(5)

Опубликована: Окт. 1, 2014

ABSTRACT Systemic lupus erythematosus (SLE) is the prototypical systemic autoimmune disease in humans and characterized by presence of hyperactive immune cells aberrant antibody responses to nuclear cytoplasmic antigens, including characteristic anti–double-stranded DNA antibodies. We performed a cross-sectional study order determine if an SLE-associated gut dysbiosis exists patients without active disease. A group 20 SLE remission, for which there was strict inclusion exclusion criteria, recruited, we used optimized Ion Torrent 16S rRNA gene-based analysis protocol decipher fecal microbial profiles these compare them with those age- sex-matched healthy control subjects. found diversity be comparable based on Shannon’s index. However, saw significantly lower Firmicutes / Bacteroidetes ratio individuals (median ratio, 1.97) than subjects 4.86; P < 0.002). corroborated quantitative PCR analysis. Notably, decrease some families also detected. This reflected, silico functional inference, overrepresentation oxidative phosphorylation glycan utilization pathways patient microbiota. IMPORTANCE Growing evidence suggests that microbiota might impact symptoms progression diseases. how why this community influences remains elucidated. first report describing intestinal dysbiosis, it contributes understanding interplay between host disorders.

Язык: Английский

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Our Gut Microbiome: The Evolving Inner Self

Cell, Год журнала: 2017, Номер 171(7), С. 1481 - 1493

Опубликована: Дек. 1, 2017

Язык: Английский

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Intestinal Microbial Diversity during Early-Life Colonization Shapes Long-Term IgE Levels

Cell Host & Microbe, Год журнала: 2013, Номер 14(5), С. 559 - 570

Опубликована: Ноя. 1, 2013

Microbial exposure following birth profoundly impacts mammalian immune system development. Microbiota alterations are associated with increased incidence of allergic and autoimmune disorders elevated serum IgE as a hallmark. The previously reported abnormally high levels in germ-free mice suggests that immunoregulatory signals from microbiota required to control basal levels. We report those low-diversity develop early life. B cells neonatal undergo isotype switching at mucosal sites CD4 T-cell- IL-4-dependent manner. A critical level microbial diversity is order inhibit induction. Elevated lead mast-cell-surface-bound exaggerated oral-induced systemic anaphylaxis. Thus, appropriate intestinal stimuli during life for inducing an network protects induction sites.

Язык: Английский

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