Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Nature Reviews Endocrinology, Год журнала: 2018, Номер 14(10), С. 576 - 590

Опубликована: Июль 25, 2018

Язык: Английский

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Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

Cell, Год журнала: 2019, Номер 178(4), С. 795 - 806.e12

Опубликована: Авг. 1, 2019

Язык: Английский

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Facing up to the global challenges of ageing

Nature, Год журнала: 2018, Номер 561(7721), С. 45 - 56

Опубликована: Авг. 30, 2018

Язык: Английский

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The Human Gut Microbiome: From Association to Modulation

Cell, Год журнала: 2018, Номер 172(6), С. 1198 - 1215

Опубликована: Март 1, 2018

Язык: Английский

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Potential roles of gut microbiome and metabolites in modulating ALS in mice

Nature, Год журнала: 2019, Номер 572(7770), С. 474 - 480

Опубликована: Июль 22, 2019

Язык: Английский

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Clinical epigenetics: seizing opportunities for translation

Nature Reviews Genetics, Год журнала: 2018, Номер 20(2), С. 109 - 127

Опубликована: Ноя. 27, 2018

Язык: Английский

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Host–microbiota interactions in immune-mediated diseases

Nature Reviews Microbiology, Год журнала: 2020, Номер 18(9), С. 521 - 538

Опубликована: Май 26, 2020

Язык: Английский

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Recognizing Depression from the Microbiota–Gut–Brain Axis

International Journal of Molecular Sciences, Год журнала: 2018, Номер 19(6), С. 1592 - 1592

Опубликована: Май 29, 2018

Major depression is one of the leading causes disability, morbidity, and mortality worldwide. The brain–gut axis functions are disturbed, revealed by a dysfunction brain, immune system, endocrine gut. Traditional treatments all target with different drugs and/or psychotherapy. Unfortunately, most patients have never received any treatment. Studies indicate that gut microbiota could be direct cause for disorder. Abnormal microbiota–gut–brain may mental disorders, while correcting these disturbance alleviate depression. Nowadays, modulation has become hot topic in treatment research disorders. Depression closely related health condition axis, maintaining/restoring normal helps prevention/therapy

Язык: Английский

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How uterine microbiota might be responsible for a receptive, fertile endometrium

Human Reproduction Update, Год журнала: 2018, Номер 24(4), С. 393 - 415

Опубликована: Март 28, 2018

Fertility depends on a receptive state of the endometrium, influenced by hormonal and anatomical adaptations, as well immune system. Local systemic immunity is greatly microbiota. Recent discoveries 16S rRNA in endometrium ability to detect low-biomass microbiota fueled notion that uterus may be indeed non-sterile compartment. To date, concept 'sterile womb' focuses utero effects offspring neonatal immunity. However, little awareness has been raised regarding importance uterine for endometrial physiology reproductive health; manifested fertility placentation.Commensal colonization widely discussed literature. The objective this review outline possible healthy, fertile uterus. We present available evidence microbiota, focusing recent findings based rRNA, depict endometrium. highlight role host tissue adaptation, conferring protection against pathogens. Based knowledge interaction mucosal cells gut with local microbiome, we want investigate potential implications commensal health.PubMed Google Scholar were searched articles English indexed from 1 January 2008 March 2018 '16S rRNA', 'uterus' related search terms assess microbiome analysis. A manual references within resulting was performed. functional contributions health, studies other body sites additionally assessed.Challenging view sterile its infancy and, no conclusions 'core microbiome' can drawn. Nevertheless, certain and/or associated compounds accumulates. presence or their constituent molecules, such polysaccharide Bacteroides fragilis capsule, go together healthy physiological function. Lessons learned suggest potentially modulate cell subsets needed implantation have morphology. Microbiota also crucial infections defending niche competing Our highlights need well-designed 'baseline' microbial representing optimal starting point subsequent placenta formation.The complex interplay processes involved pregnancy still poorly understood. correct state, including environment, not only but formation since initiation placentation highly cells. Implantation failure, recurrent loss, pathologies placenta, pre-eclampsia, represent an increasing societal burden. More robust are colonization. current data, future research needs include relevant factor order understand players pregnancy.

Язык: Английский

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Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease

European Heart Journal, Год журнала: 2020, Номер 41(31), С. 2974 - 2982

Опубликована: Янв. 9, 2020

Abstract The ongoing worldwide increase in life expectancy portends a rising prevalence of age-related cardiovascular (CV) diseases the coming decades that demands deeper understanding their molecular mechanisms. Inflammation has recently emerged as an important contributor for CV disease development. Indeed, state chronic sterile low-grade inflammation characterizes older organisms (also known inflamm-ageing) and participates pivotally development frailty, disability, most degenerative including cerebrovascular afflictions. Due to activation inflammasomes reduced endogenous anti-inflammatory mechanisms, inflamm-ageing contributes leucocytes, endothelial, vascular smooth muscle cells, thus accelerating ageing atherosclerosis. Furthermore, promotes catastrophic athero-thrombotic complications by enhancing platelet reactivity predisposing plaque rupture erosion. Thus, its contributors or mediators might furnish targets novel therapeutic strategies could promote healthy conserve resources health care systems worldwide. Here, we discuss recent findings pathophysiology inflamm-ageing, impact these processes on diseases, results from clinical trials targeting components potential implementation advances into daily practice.

Язык: Английский

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