Diversity of astrocyte functions and phenotypes in neural circuits

Nature Neuroscience, Год журнала: 2015, Номер 18(7), С. 942 - 952

Опубликована: Июнь 25, 2015

Язык: Английский

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From the neuron doctrine to neural networks

Nature reviews. Neuroscience, Год журнала: 2015, Номер 16(8), С. 487 - 497

Опубликована: Июль 8, 2015

Язык: Английский

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In vivo imaging of neural activity

Nature Methods, Год журнала: 2017, Номер 14(4), С. 349 - 359

Опубликована: Март 31, 2017

Язык: Английский

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Cooperative and Competitive Spreading Dynamics on the Human Connectome

Neuron, Год журнала: 2015, Номер 86(6), С. 1518 - 1529

Опубликована: Июнь 1, 2015

Язык: Английский

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Single-Cell Transcriptomics Meets Lineage Tracing

Cell stem cell, Год журнала: 2018, Номер 23(2), С. 166 - 179

Опубликована: Май 10, 2018

Язык: Английский

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Molecular basis of astrocyte diversity and morphology across the CNS in health and disease

Science, Год журнала: 2022, Номер 378(6619)

Опубликована: Ноя. 3, 2022

Astrocytes, a type of glia, are abundant and morphologically complex cells. Here, we report astrocyte molecular profiles, diversity, morphology across the mouse central nervous system (CNS). We identified shared region-specific astrocytic genes functions explored cellular origins their regional diversity. gene networks correlated with morphology, several which unexpectedly contained Alzheimer’s disease (AD) risk genes. CRISPR/Cas9–mediated reduction candidate reduced morphological complexity resulted in cognitive deficits. The same were down-regulated human AD, an AD model that displayed other brain disorders. thus provide comprehensive data on diversity mechanisms CNS basis health disease.

Язык: Английский

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Heterogeneity of Alcohol Use Disorder: Understanding Mechanisms to Advance Personalized Treatment

Alcoholism Clinical and Experimental Research, Год журнала: 2015, Номер 39(4), С. 579 - 584

Опубликована: Апрель 1, 2015

Язык: Английский

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A prospective randomized evaluation of the TriGuard™ HDH embolic DEFLECTion device during transcatheter aortic valve implantation: results from the DEFLECT III trial

European Heart Journal, Год журнала: 2015, Номер 36(31), С. 2070 - 2078

Опубликована: Май 19, 2015

AimsTo evaluate the safety, efficacy, and performance of TriGuard™ HDH Embolic Deflection Device (TriGuard) compared with no cerebral protection in patients undergoing transcatheter aortic valve implantation (TAVI).

Язык: Английский

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Progress and challenges in probing the human brain

Nature, Год журнала: 2015, Номер 526(7573), С. 371 - 379

Опубликована: Окт. 1, 2015

Язык: Английский

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Comparing spatial null models for brain maps

NeuroImage, Год журнала: 2021, Номер 236, С. 118052 - 118052

Опубликована: Апрель 19, 2021

Technological and data sharing advances have led to a proliferation of high-resolution structural functional maps the brain. Modern neuroimaging research increasingly depends on identifying correspondences between topographies these maps; however, most standard methods for statistical inference fail account their spatial properties. Recently, multiple been developed generate null distributions that preserve autocorrelation brain yield more accurate estimates. Here, we comprehensively assess performance ten published frameworks in analyses data. To test efficacy situations with known ground truth, first apply them series controlled simulations examine impact resolution family-wise error rates. Next, use each framework two empirical datasets, investigating when testing (1) correspondence (e.g., correlating activation maps) (2) distribution feature within partition quantifying specificity an map intrinsic network). Finally, investigate how differences implementation models may performance. In agreement previous reports, find naive do not consistently elevated false positive rates unrealistically liberal While spatially-constrained yielded realistic, conservative estimates, even suffer from inflated variable across analyses. Throughout our results, observe minimal parcellation model Altogether, findings highlight need continued development statistically-rigorous comparing maps. The present report provides harmonised benchmarking future advancements.

Язык: Английский

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