Liquid biopsies come of age: towards implementation of circulating tumour DNA

Nature reviews. Cancer, Год журнала: 2017, Номер 17(4), С. 223 - 238

Опубликована: Фев. 24, 2017

Язык: Английский

---

Tracking the Evolution of Non–Small-Cell Lung Cancer

New England Journal of Medicine, Год журнала: 2017, Номер 376(22), С. 2109 - 2121

Опубликована: Апрель 26, 2017

Among patients with non-small-cell lung cancer (NSCLC), data on intratumor heterogeneity and genome evolution have been limited to small retrospective cohorts. We wanted prospectively investigate in relation clinical outcome determine the clonal nature of driver events evolutionary processes early-stage NSCLC.

Язык: Английский

---

The Human Cell Atlas

eLife, Год журнала: 2017, Номер 6

Опубликована: Дек. 5, 2017

The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that time is ripe to complete 150-year-old effort identify all cell types human body. Human Cell Atlas Project an international collaborative aims define terms distinctive profiles (such as gene expression profiles) and connect this information with classical cellular descriptions location morphology). An open comprehensive reference map state cells healthy tissues would propel systematic study physiological states, developmental trajectories, regulatory circuitry interactions cells, also provide framework understanding dysregulation disease. Here we describe idea, its potential utility, early proofs-of-concept, some design considerations Atlas, including commitment data, code, community.

Язык: Английский

---

Universal Patterns of Selection in Cancer and Somatic Tissues

Cell, Год журнала: 2017, Номер 171(5), С. 1029 - 1041.e21

Опубликована: Окт. 19, 2017

Cancer develops as a result of somatic mutation and clonal selection, but quantitative measures selection in cancer evolution are lacking. We adapted methods from molecular applied them to 7,664 tumors across 29 types. Unlike species evolution, positive outweighs negative during development. On average, <1 coding base substitution/tumor is lost through with purifying almost absent outside homozygous loss essential genes. This allows exome-wide enumeration all driver mutations, including known carry ∼4 substitutions under ranging <1/tumor thyroid testicular cancers >10/tumor endometrial colorectal cancers. Half occur yet-to-be-discovered With increasing burden, numbers mutations increase, not linearly. systematically catalog genes show that vary extensively what proportion drivers versus passengers.

Язык: Английский

---

Somatic mutation in cancer and normal cells

Science, Год журнала: 2015, Номер 349(6255), С. 1483 - 1489

Опубликована: Сен. 24, 2015

Spontaneously occurring mutations accumulate in somatic cells throughout a person’s lifetime. The majority of these do not have noticeable effect, but some can alter key cellular functions. Early cause developmental disorders, whereas the progressive accumulation life lead to cancer and contribute aging. Genome sequencing has revolutionized our understanding mutation cancer, providing detailed view mutational processes genes that drive cancer. Yet, fundamental gaps remain knowledge how normal evolve into cells. We briefly summarize number lessons learned over 5 years genome discuss their implications for progression

Язык: Английский

---

A compendium of mutational cancer driver genes

Nature reviews. Cancer, Год журнала: 2020, Номер 20(10), С. 555 - 572

Опубликована: Авг. 10, 2020

Язык: Английский

---

Somatic mutant clones colonize the human esophagus with age

Science, Год журнала: 2018, Номер 362(6417), С. 911 - 917

Опубликована: Окт. 19, 2018

The mutational burden of aging As people age, they accumulate somatic mutations in healthy cells. About 25% cells normal, sun-exposed skin harbor cancer driver mutations. What about tissues not exposed to powerful mutagens like ultraviolet light? Martincorena et al. performed targeted gene sequencing normal esophageal epithelium from nine human donors varying age (see the Perspective by Chanock). mutation rate was lower esophagus than skin, but there a strong positive selection clones carrying 14 cancer-associated genes. By middle more half colonized mutant clones. Interestingly, NOTCH1 were common cancer. Science , this issue p. 911 ; see also 893

Язык: Английский

---

Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges

Cell stem cell, Год журнала: 2020, Номер 27(4), С. 523 - 531

Опубликована: Окт. 1, 2020

Язык: Английский

---

The evolutionary history of 2,658 cancers

Nature, Год журнала: 2020, Номер 578(7793), С. 122 - 128

Опубликована: Фев. 5, 2020

Cancer develops through a process of somatic evolution

Язык: Английский

---

Tissue-specific mutation accumulation in human adult stem cells during life

Nature, Год журнала: 2016, Номер 538(7624), С. 260 - 264

Опубликована: Сен. 30, 2016

Язык: Английский

---