The multifaceted roles of fatty acid synthesis in cancer

Nature reviews. Cancer, Год журнала: 2016, Номер 16(11), С. 732 - 749

Опубликована: Сен. 23, 2016

Язык: Английский

---

Ubiquitin Ligases: Structure, Function, and Regulation

Annual Review of Biochemistry, Год журнала: 2017, Номер 86(1), С. 129 - 157

Опубликована: Апрель 4, 2017

Ubiquitin E3 ligases control every aspect of eukaryotic biology by promoting protein ubiquitination and degradation. At the end a three-enzyme cascade, ubiquitin mediate transfer from an E2 ubiquitin-conjugating enzyme to specific substrate proteins. Early investigations E3s RING (really interesting new gene) HECT (homologous E6AP carboxyl terminus) types shed light on their enzymatic activities, general architectures, degron-binding modes. Recent studies have provided deeper mechanistic insights into catalysis, activation, regulation. In this review, we summarize current progress in structure-function as well exciting discoveries novel classes diverse recognition mechanisms. Our increased understanding ligase function regulation has rationale for developing E3-targeting therapeutics treatment human diseases.

Язык: Английский

---

Induced protein degradation: an emerging drug discovery paradigm

Nature Reviews Drug Discovery, Год журнала: 2016, Номер 16(2), С. 101 - 114

Опубликована: Ноя. 25, 2016

Язык: Английский

---

Transcriptional Addiction in Cancer

Cell, Год журнала: 2017, Номер 168(4), С. 629 - 643

Опубликована: Фев. 1, 2017

Язык: Английский

---

Structural basis of PROTAC cooperative recognition for selective protein degradation

Nature Chemical Biology, Год журнала: 2017, Номер 13(5), С. 514 - 521

Опубликована: Март 13, 2017

Язык: Английский

---

YY1 Is a Structural Regulator of Enhancer-Promoter Loops

Cell, Год журнала: 2017, Номер 171(7), С. 1573 - 1588.e28

Опубликована: Дек. 1, 2017

Язык: Английский

---

The dTAG system for immediate and target-specific protein degradation

Nature Chemical Biology, Год журнала: 2018, Номер 14(5), С. 431 - 441

Опубликована: Март 26, 2018

Язык: Английский

---

Proteasome inhibitors in cancer therapy

Nature Reviews Clinical Oncology, Год журнала: 2017, Номер 14(7), С. 417 - 433

Опубликована: Янв. 24, 2017

Язык: Английский

---

Proteome-wide covalent ligand discovery in native biological systems

Nature, Год журнала: 2016, Номер 534(7608), С. 570 - 574

Опубликована: Июнь 14, 2016

Язык: Английский

---

Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

Cell, Год журнала: 2020, Номер 181(1), С. 102 - 114

Опубликована: Янв. 16, 2020

Язык: Английский

---