Stem cell competition orchestrates skin homeostasis and ageing

Nature, Год журнала: 2019, Номер 568(7752), С. 344 - 350

Опубликована: Апрель 3, 2019

Язык: Английский

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Prospects for gene-engineered T cell immunotherapy for solid cancers

Nature Medicine, Год журнала: 2016, Номер 22(1), С. 26 - 36

Опубликована: Янв. 1, 2016

Язык: Английский

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Antigen-Presenting Cells in the Skin

Annual Review of Immunology, Год журнала: 2017, Номер 35(1), С. 469 - 499

Опубликована: Фев. 22, 2017

Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes, and macrophages. They are highly dynamic, with capacity to enter from peripheral circulation, patrol within tissue, migrate through lymphatics draining lymph nodes. Skin APCs endowed antigen-sensing, -processing, -presenting machinery play key roles initiating, modulating, resolving cutaneous inflammation. a heterogeneous population functionally specialized subsets that developmentally imprinted modulated by local tissue microenvironmental inflammatory cues. This review explores recent advances have allowed for more accurate taxonomy of APC found both mouse human skin. It also examines functional specificity individual their collaboration other immune cell types together promote adaptive T regional responses during homeostasis, inflammation, disease.

Язык: Английский

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The genomics of oxidative DNA damage, repair, and resulting mutagenesis

Computational and Structural Biotechnology Journal, Год журнала: 2020, Номер 18, С. 207 - 219

Опубликована: Янв. 1, 2020

Reactive oxygen species are a constant threat to DNA as they modify bases with the risk of disrupting genome function, inducing instability and mutation. Such risks due primary oxidative damage also mediated by repair process. This leads delicate decision process for cell whether damaged base at specific genomic location or better leave it unrepaired. Persistent can disrupt but on other hand contribute gene regulation serving an epigenetic mark. When such processes out balance, pathophysiological conditions could get accelerated, because resulting mutagenic tightly linked ageing, inflammation, development multiple age-related diseases, cancer neurodegenerative disorders. Recent technological advancements novel data analysis strategies have revealed that damage, its repair, related mutations distribute heterogeneously over levels resolution. The involved mechanisms act in context sequence, interaction function chromatin. review addresses what we currently know about distribution intermediates, mutations. It will specifically focus various methodologies measure discuss mechanistic conclusions derived from different approaches. address consequences how gives rise mutations, instability,

Язык: Английский

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Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease

Nature Reviews Cardiology, Год журнала: 2019, Номер 17(3), С. 137 - 144

Опубликована: Авг. 12, 2019

Язык: Английский

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