Antioxidants,
Год журнала:
2018,
Номер
7(1), С. 13 - 13
Опубликована: Янв. 16, 2018
Mitochondria
are
organelles
with
a
highly
dynamic
ultrastructure
maintained
by
delicate
equilibrium
between
its
fission
and
fusion
rates.
Understanding
the
factors
influencing
this
balance
is
important
as
perturbations
to
mitochondrial
dynamics
can
result
in
pathological
states.
As
terminal
site
of
nutrient
oxidation
for
cell,
powerhouses
harness
energy
form
ATP
process
driven
electron
transport
chain.
Contemporaneously,
electrons
translocated
within
chain
undergo
spontaneous
side
reactions
oxygen,
giving
rise
superoxide
variety
other
downstream
reactive
oxygen
species
(ROS).
Mitochondrially-derived
ROS
mediate
redox
signaling
or,
excess,
cause
cell
injury
even
death.
Recent
evidence
suggests
that
tightly
coupled
generation
depending
on
physiological
status
cell.
Yet,
mechanism
which
changes
shape
modulate
function
homeostasis
less
clear.
Aberrant
morphology
may
lead
enhanced
formation,
which,
turn,
deteriorate
health
further
exacerbate
oxidative
stress
self-perpetuating
vicious
cycle.
Here,
we
review
latest
findings
intricate
relationship
production,
focusing
mainly
role
malignant
disease.
Essays in Biochemistry,
Год журнала:
2018,
Номер
62(3), С. 341 - 360
Опубликована: Июль 20, 2018
Mitochondria
are
highly
dynamic
organelles
undergoing
coordinated
cycles
of
fission
and
fusion,
referred
as
‘mitochondrial
dynamics’,
in
order
to
maintain
their
shape,
distribution
size.
Their
transient
rapid
morphological
adaptations
crucial
for
many
cellular
processes
such
cell
cycle,
immunity,
apoptosis
mitochondrial
quality
control.
Mutations
the
core
machinery
components
defects
dynamics
have
been
associated
with
numerous
human
diseases.
These
transitions
mainly
ensured
by
large
GTPases
belonging
Dynamin
family.
Mitochondrial
is
a
multi-step
process
allowing
division
one
mitochondrion
two
daughter
mitochondria.
It
regulated
recruitment
GTPase
Dynamin-related
protein
1
(Drp1)
adaptors
at
actin-
endoplasmic
reticulum-mediated
constriction
sites.
Drp1
oligomerization
followed
leads
2
terminate
membrane
scission.
Inner
has
proposed
be
an
independent
calcium
influx.
fusion
driven
two-step
outer
mediated
mitofusins
inner
optic
atrophy
1.
In
addition
role
lipid
composition,
several
members
can
undergo
post-translational
modifications
modulating
these
processes.
Understanding
molecular
mechanisms
controlling
decipher
how
shape
meets
function
increase
knowledge
on
basis
diseases
morphology
defects.
This
article
will
describe
overview
that
govern
mammals.
Annual Review of Pathology Mechanisms of Disease,
Год журнала:
2019,
Номер
15(1), С. 235 - 259
Опубликована: Окт. 5, 2019
The
dynamic
properties
of
mitochondria-including
their
fusion,
fission,
and
degradation-are
critical
for
optimal
function
in
energy
generation.
interplay
fusion
fission
confers
widespread
benefits
on
mitochondria,
including
efficient
transport,
increased
homogenization
the
mitochondrial
population,
oxidative
phosphorylation.
These
arise
through
control
morphology,
content
exchange,
equitable
inheritance
maintenance
high-quality
DNA,
segregation
damaged
mitochondria
degradation.
key
components
machinery
mediating
belong
to
dynamin
family
GTPases
that
utilize
GTP
hydrolysis
drive
mechanical
work
biological
membranes.
Defects
this
cause
a
range
diseases
especially
affect
nervous
system.
In
addition,
several
common
diseases,
neurodegenerative
cancer,
strongly
dynamics.
