Frontiers in Cell and Developmental Biology,
Год журнала:
2020,
Номер
8
Опубликована: Июнь 24, 2020
Mitochondria
are
highly
plastic
and
dynamic
organelles
that
have
graded
responses
to
the
changing
cellular,
environmental
developmental
cues.
undergo
constant
mitochondrial
fission
fusion,
biogenesis
mitophagy,
which
coordinately
control
morphology,
quantity,
quality,
turnover
inheritance.
Mitophagy
is
a
cellular
process
selectively
removes
aged
damaged
mitochondria
via
specific
sequestration
engulfment
of
for
subsequent
lysosomal
degradation.
It
plays
pivotal
role
reinstate
homeostasis
in
normal
physiology
conditions
stress.
Damaged
may
either
instigate
innate
immunity
through
overproduction
ROS
or
release
mtDNA,
trigger
cell
death
cytochrome
c
other
apoptogenic
factors
when
damage
beyond
repair.
Distinct
molecular
machineries
signaling
pathways
found
regulate
these
dynamics
behaviors.
less
clear
how
behaviors
coordinated
at
levels.
BCL2
family
proteins
interact
within
members
outer
membrane
permeabilization
apoptosis.
They
were
also
described
as
global
regulators
fate
their
interaction
with
distinct
partners
including
Drp1,
mitofusins,
PGAM5
even
LC3
involved
In
this
review,
we
summarize
recent
findings
on
governing
mitophagy
its
coordination
behaviors,
together
determine
fate.
Essays in Biochemistry,
Год журнала:
2018,
Номер
62(3), С. 341 - 360
Опубликована: Июль 20, 2018
Mitochondria
are
highly
dynamic
organelles
undergoing
coordinated
cycles
of
fission
and
fusion,
referred
as
‘mitochondrial
dynamics’,
in
order
to
maintain
their
shape,
distribution
size.
Their
transient
rapid
morphological
adaptations
crucial
for
many
cellular
processes
such
cell
cycle,
immunity,
apoptosis
mitochondrial
quality
control.
Mutations
the
core
machinery
components
defects
dynamics
have
been
associated
with
numerous
human
diseases.
These
transitions
mainly
ensured
by
large
GTPases
belonging
Dynamin
family.
Mitochondrial
is
a
multi-step
process
allowing
division
one
mitochondrion
two
daughter
mitochondria.
It
regulated
recruitment
GTPase
Dynamin-related
protein
1
(Drp1)
adaptors
at
actin-
endoplasmic
reticulum-mediated
constriction
sites.
Drp1
oligomerization
followed
leads
2
terminate
membrane
scission.
Inner
has
proposed
be
an
independent
calcium
influx.
fusion
driven
two-step
outer
mediated
mitofusins
inner
optic
atrophy
1.
In
addition
role
lipid
composition,
several
members
can
undergo
post-translational
modifications
modulating
these
processes.
Understanding
molecular
mechanisms
controlling
decipher
how
shape
meets
function
increase
knowledge
on
basis
diseases
morphology
defects.
This
article
will
describe
overview
that
govern
mammals.
Annual Review of Pathology Mechanisms of Disease,
Год журнала:
2019,
Номер
15(1), С. 235 - 259
Опубликована: Окт. 5, 2019
The
dynamic
properties
of
mitochondria-including
their
fusion,
fission,
and
degradation-are
critical
for
optimal
function
in
energy
generation.
interplay
fusion
fission
confers
widespread
benefits
on
mitochondria,
including
efficient
transport,
increased
homogenization
the
mitochondrial
population,
oxidative
phosphorylation.
These
arise
through
control
morphology,
content
exchange,
equitable
inheritance
maintenance
high-quality
DNA,
segregation
damaged
mitochondria
degradation.
key
components
machinery
mediating
belong
to
dynamin
family
GTPases
that
utilize
GTP
hydrolysis
drive
mechanical
work
biological
membranes.
Defects
this
cause
a
range
diseases
especially
affect
nervous
system.
In
addition,
several
common
diseases,
neurodegenerative
cancer,
strongly
dynamics.
