Progress in Lipid Research,
Год журнала:
2023,
Номер
91, С. 101235 - 101235
Опубликована: Май 15, 2023
Lipids
play
important
roles
in
energy
metabolism
along
with
diverse
aspects
of
biological
membrane
structure,
signaling
and
other
functions.
Perturbations
lipid
are
responsible
for
the
development
various
pathologies
comprising
metabolic
syndrome,
obesity,
type
2
diabetes.
Accumulating
evidence
suggests
that
circadian
oscillators,
operative
most
cells
our
body,
coordinate
temporal
homeostasis.
In
this
review
we
summarize
current
knowledge
on
regulation
digestion,
absorption,
transportation,
biosynthesis,
catabolism,
storage.
Specifically,
focus
molecular
interactions
between
functional
clockwork
biosynthetic
pathways
major
classes
cholesterol,
fatty
acids,
triacylglycerols,
glycerophospholipids,
glycosphingolipids,
sphingomyelins.
A
growing
body
epidemiological
studies
associate
a
socially
imposed
misalignment
common
modern
society
incidence
disorders,
however
disruption
rhythms
connection
has
only
been
recently
revealed.
Here,
highlight
recent
unravel
mechanistic
link
intracellular
clocks,
homeostasis
diseases
based
animal
models
clock
innovative
translational
humans.
We
also
discuss
perspectives
manipulating
oscillators
as
potentially
powerful
approach
preventing
managing
disorders
human
patients.
Science,
Год журнала:
2016,
Номер
354(6315), С. 1008 - 1015
Опубликована: Ноя. 24, 2016
A
majority
of
mammalian
genes
exhibit
daily
fluctuations
in
expression
levels,
making
circadian
rhythms
the
largest
known
regulatory
network
normal
physiology.
Cell-autonomous
clocks
interact
with
light-dark
and
feeding-fasting
cycles
to
generate
approximately
24-hour
oscillations
function
thousands
genes.
Circadian
secreted
molecules
signaling
components
transmits
timing
information
between
cells
tissues.
Such
intra-
intercellular
optimize
physiology
both
by
managing
energy
use
temporally
segregating
incompatible
processes.
Experimental
animal
models
epidemiological
data
indicate
that
chronic
rhythm
disruption
increases
risk
metabolic
diseases.
Conversely,
time-restricted
feeding,
which
imposes
feeding
fasting
without
caloric
reduction,
sustains
robust
diurnal
can
alleviate
These
findings
highlight
an
integrative
role
offer
a
new
perspective
for
treating
diseases
is
hallmark.
Science,
Год журнала:
2016,
Номер
354(6315), С. 994 - 999
Опубликована: Ноя. 24, 2016
Biological
clocks
are
autonomous
anticipatory
oscillators
that
play
a
critical
role
in
the
organization
and
information
processing
from
genome
to
whole
organisms.
Transformative
advances
into
clock
system
have
opened
insight
fundamental
mechanisms
through
which
program
energy
transfer
sunlight
organic
matter
potential
energy,
addition
cell
development
genotoxic
stress
response.
The
identification
of
nearly
every
single
body
raises
questions
as
how
this
gives
rise
rhythmic
physiology
multicellular
organisms
environmental
signals
entrain
geophysical
time.
Here,
we
consider
understanding
regulatory
networks
emergent
give
type-specific
functions
within
tissues
affect
homeostasis.
Abstract
Circadian
clocks
are
endogenous
oscillators
that
control
24-h
physiological
and
behavioral
processes.
The
central
circadian
clock
exerts
over
myriad
aspects
of
mammalian
physiology,
including
the
regulation
sleep,
metabolism,
immune
system.
Here,
we
review
advances
in
understanding
genetic
sleep
through
system,
as
well
impact
dysregulated
gene
expression
on
metabolic
function.
We
also
recent
studies
have
begun
to
unravel
clock’s
role
controlling
cardiovascular
nervous
systems,
gut
microbiota,
cancer,
aging.
Such
these
systems
relies,
part,
transcriptional
regulation,
with
evidence
for
genome-wide
chromosome
organization.
These
novel
insights
into
genomic
human
physiology
provide
opportunities
discovery
improved
treatment
strategies
new
biological
underpinnings
disease.
New England Journal of Medicine,
Год журнала:
2021,
Номер
384(6), С. 550 - 561
Опубликована: Фев. 10, 2021
Molecular
insights
into
diurnal
variations
in
human
physiology
and
behavior
are
extending
our
understanding
of
a
wide
range
disease
processes.
Chronobiology
is
also
providing
testable
hypotheses
regarding
the
timing
treatments.
