Parkinson's disease and Parkinson's disease medications have distinct signatures of the gut microbiome DOI

Erin M. Hill‐Burns,

Justine W. Debelius, James T. Morton

и другие.

Movement Disorders, Год журнала: 2017, Номер 32(5), С. 739 - 749

Опубликована: Фев. 14, 2017

There is mounting evidence for a connection between the gut and Parkinson's disease (PD). Dysbiosis of microbiota could explain several features PD.

Язык: Английский

The Microbiota-Gut-Brain Axis DOI Open Access
John F. Cryan, Kenneth J. O’Riordan, Caitlin S.M. Cowan

и другие.

Physiological Reviews, Год журнала: 2019, Номер 99(4), С. 1877 - 2013

Опубликована: Авг. 28, 2019

The importance of the gut-brain axis in maintaining homeostasis has long been appreciated. However, past 15 yr have seen emergence microbiota (the trillions microorganisms within and on our bodies) as one key regulators function led to appreciation a distinct microbiota-gut-brain axis. This is gaining ever more traction fields investigating biological physiological basis psychiatric, neurodevelopmental, age-related, neurodegenerative disorders. brain communicate with each other via various routes including immune system, tryptophan metabolism, vagus nerve enteric nervous involving microbial metabolites such short-chain fatty acids, branched chain amino peptidoglycans. Many factors can influence composition early life, infection, mode birth delivery, use antibiotic medications, nature nutritional provision, environmental stressors, host genetics. At extreme diversity diminishes aging. Stress, particular, significantly impact at all stages life. Much recent work implicated gut many conditions autism, anxiety, obesity, schizophrenia, Parkinson’s disease, Alzheimer’s disease. Animal models paramount linking regulation fundamental neural processes, neurogenesis myelination, microbiome activation microglia. Moreover, translational human studies are ongoing will greatly enhance field. Future focus understanding mechanisms underlying attempt elucidate microbial-based intervention therapeutic strategies for neuropsychiatric

Язык: Английский

Процитировано

3512

The Human Intestinal Microbiome in Health and Disease DOI
Susan V. Lynch, Oluf Pedersen

New England Journal of Medicine, Год журнала: 2016, Номер 375(24), С. 2369 - 2379

Опубликована: Дек. 14, 2016

The large majority of studies on the role microbiome in pathogenesis disease are correlative and preclinical; several have influenced clinical practice.

Язык: Английский

Процитировано

3016

Environment dominates over host genetics in shaping human gut microbiota DOI
Daphna Rothschild, Omer Weissbrod, Elad Barkan

и другие.

Nature, Год журнала: 2018, Номер 555(7695), С. 210 - 215

Опубликована: Фев. 28, 2018

Язык: Английский

Процитировано

2309

Role of the gut microbiota in nutrition and health DOI Creative Commons
Ana M. Valdes, Jens Walter, Eran Segal

и другие.

BMJ, Год журнала: 2018, Номер unknown, С. k2179 - k2179

Опубликована: Июнь 13, 2018

Role of the gut microbiota in nutrition and healthAna M Valdes colleagues discuss strategies for modulating

Язык: Английский

Процитировано

1905

Microbiota in health and diseases DOI Creative Commons
Kejun Hou,

Zhuo‐Xun Wu,

Xuan-Yu Chen

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2022, Номер 7(1)

Опубликована: Апрель 23, 2022

Abstract The role of microbiota in health and diseases is being highlighted by numerous studies since its discovery. Depending on the localized regions, can be classified into gut, oral, respiratory, skin microbiota. microbial communities are symbiosis with host, contributing to homeostasis regulating immune function. However, dysbiosis lead dysregulation bodily functions including cardiovascular (CVDs), cancers, respiratory diseases, etc. In this review, we discuss current knowledge how links host or pathogenesis. We first summarize research healthy conditions, gut-brain axis, colonization resistance modulation. Then, highlight pathogenesis disease development progression, primarily associated community composition, modulation response, induction chronic inflammation. Finally, introduce clinical approaches that utilize for treatment, such as fecal transplantation.

Язык: Английский

Процитировано

1666

Extensive impact of non-antibiotic drugs on human gut bacteria DOI
Lisa Maier, Mihaela Pruteanu, Michael Kuhn

и другие.

Nature, Год журнала: 2018, Номер 555(7698), С. 623 - 628

Опубликована: Март 19, 2018

Язык: Английский

Процитировано

1632

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity DOI
Alexandra Zhernakova, Alexander Kurilshikov, Marc Jan Bonder

и другие.

Science, Год журнала: 2016, Номер 352(6285), С. 565 - 569

Опубликована: Апрель 28, 2016

“Normal” for the gut microbiota For benefit of future clinical studies, it is critical to establish what constitutes a “normal” microbiome, if exists at all. Through fecal samples and questionnaires, Falony et al. Zhernakova targeted general populations in Belgium Netherlands, respectively. Gut composition correlated with range factors including diet, use medication, red blood cell counts, chromogranin A, stool consistency. The data give some hints possible biomarkers normal communities. Science , this issue pp. 560 565

Язык: Английский

Процитировано

1622

The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota DOI Open Access
Christian Milani, Sabrina Duranti, Francesca Bottacini

и другие.

Microbiology and Molecular Biology Reviews, Год журнала: 2017, Номер 81(4)

Опубликована: Ноя. 8, 2017

SUMMARY The human gut microbiota is engaged in multiple interactions affecting host health during the host's entire life span. Microbes colonize neonatal immediately following birth. establishment and interactive development of this early are believed to be (at least partially) driven modulated by specific compounds present milk. It has been shown that certain genomes infant commensals, particular those bifidobacterial species, genetically adapted utilize glycans secretory fluid, thus representing a very intriguing example host-microbe coevolution, where both partners benefit. In recent years, various metagenomic studies have tried dissect composition functionality microbiome explore distribution across different ecological niches biogeography corresponding microbial consortia, including bacteria viruses, healthy ill subjects. Such analyses linked features microbiota/microbiome, such as reduced diversity or aberrant composition, intestinal illnesses infants disease states manifested at later stages life, asthma, inflammatory bowel disease, metabolic disorders. Thus, growing number reported on how composition/development may affect risk factors related adult conditions. This concept fueled strategies shape based functional food products. review, we describe microbiota, mechanisms drive its consortia molded natural artificial interventions. Finally, discuss relevance key players bifidobacteria, with respect their role disease.

Язык: Английский

Процитировано

1586

The neuroactive potential of the human gut microbiota in quality of life and depression DOI
Mireia Valles‐Colomer, Gwen Falony, Youssef Darzi

и другие.

Nature Microbiology, Год журнала: 2019, Номер 4(4), С. 623 - 632

Опубликована: Фев. 4, 2019

Язык: Английский

Процитировано

1562

Shotgun metagenomics, from sampling to analysis DOI
Christopher Quince, Alan W. Walker, Jared T. Simpson

и другие.

Nature Biotechnology, Год журнала: 2017, Номер 35(9), С. 833 - 844

Опубликована: Сен. 1, 2017

Язык: Английский

Процитировано

1555