A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Cell, Год журнала: 2017, Номер 169(7), С. 1276 - 1290.e17

Опубликована: Июнь 1, 2017

Язык: Английский

---

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease

Cell, Год журнала: 2016, Номер 167(6), С. 1469 - 1480.e12

Опубликована: Дек. 1, 2016

Язык: Английский

---

Interaction between microbiota and immunity in health and disease

Cell Research, Год журнала: 2020, Номер 30(6), С. 492 - 506

Опубликована: Май 20, 2020

Abstract The interplay between the commensal microbiota and mammalian immune system development function includes multifold interactions in homeostasis disease. microbiome plays critical roles training of major components host’s innate adaptive system, while orchestrates maintenance key features host-microbe symbiosis. In a genetically susceptible host, imbalances microbiota-immunity under defined environmental contexts are believed to contribute pathogenesis multitude immune-mediated disorders. Here, we review microbiome-immunity crosstalk their health disease, providing examples molecular mechanisms orchestrating these intestine extra-intestinal organs. We highlight aspects current knowledge, challenges limitations achieving causal understanding host immune-microbiome interactions, as well impact on diseases, discuss how insights may translate towards future microbiome-targeted therapeutic interventions.

Язык: Английский

---

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

Immunity, Год журнала: 2017, Номер 47(3), С. 566 - 581.e9

Опубликована: Сен. 1, 2017

Язык: Английский

---

Microglia Function in the Central Nervous System During Health and Neurodegeneration

Annual Review of Immunology, Год журнала: 2017, Номер 35(1), С. 441 - 468

Опубликована: Фев. 22, 2017

Microglia are resident cells of the brain that regulate development, maintenance neuronal networks, and injury repair. serve as macrophages but distinct from other tissue owing to their unique homeostatic phenotype tight regulation by central nervous system (CNS) microenvironment. They responsible for elimination microbes, dead cells, redundant synapses, protein aggregates, particulate soluble antigens may endanger CNS. Furthermore, primary source proinflammatory cytokines, microglia pivotal mediators neuroinflammation can induce or modulate a broad spectrum cellular responses. Alterations in functionality implicated development aging, well neurodegeneration. Recent observations about ontogeny combined with extensive gene expression profiling novel tools study biology have allowed us characterize microglial phenotypes during homeostasis, disease. In this article, we review recent advances our understanding microglia, contribution involvement Moreover, highlight complexity targeting therapeutic intervention neurodegenerative diseases.

Язык: Английский

---

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

Immunity, Год журнала: 2018, Номер 50(1), С. 253 - 271.e6

Опубликована: Ноя. 21, 2018

Язык: Английский

---

Microglia and macrophages in brain homeostasis and disease

Nature reviews. Immunology, Год журнала: 2017, Номер 18(4), С. 225 - 242

Опубликована: Ноя. 20, 2017

Язык: Английский

---

Interactions between the microbiota, immune and nervous systems in health and disease

Nature Neuroscience, Год журнала: 2017, Номер 20(2), С. 145 - 155

Опубликована: Янв. 16, 2017

Язык: Английский

---

Microglia emerge as central players in brain disease

Nature Medicine, Год журнала: 2017, Номер 23(9), С. 1018 - 1027

Опубликована: Сен. 1, 2017

Язык: Английский

---

The Central Nervous System and the Gut Microbiome

Cell, Год журнала: 2016, Номер 167(4), С. 915 - 932

Опубликована: Ноя. 1, 2016

Язык: Английский

---