Cell Metabolism,
Год журнала:
2019,
Номер
30(6), С. 1055 - 1074.e8
Опубликована: Ноя. 7, 2019
Accumulation
of
lactate
in
the
tissue
microenvironment
is
a
feature
both
inflammatory
disease
and
cancer.
Here,
we
assess
response
immune
cells
to
context
chronic
inflammation.
We
report
that
accumulation
inflamed
contributes
upregulation
transporter
SLC5A12
by
human
CD4+
T
cells.
SLC5A12-mediated
uptake
into
induces
reshaping
their
effector
phenotype,
resulting
increased
IL17
production
via
nuclear
PKM2/STAT3
enhanced
fatty
acid
synthesis.
It
also
leads
cell
retention
as
consequence
reduced
glycolysis
Furthermore,
antibody-mediated
blockade
ameliorates
severity
murine
model
arthritis.
Finally,
propose
lactate/SLC5A12-induced
metabolic
reprogramming
distinctive
lymphoid
synovitis
rheumatoid
arthritis
patients
potential
therapeutic
target
disorders.
Nature Communications,
Год журнала:
2020,
Номер
11(1)
Опубликована: Янв. 3, 2020
Abstract
Mitochondria
are
signaling
organelles
that
regulate
a
wide
variety
of
cellular
functions
and
can
dictate
cell
fate.
Multiple
mechanisms
contribute
to
communicate
mitochondrial
fitness
the
rest
cell.
Recent
evidence
confers
new
role
for
TCA
cycle
intermediates,
generally
thought
be
important
biosynthetic
purposes,
as
molecules
with
controlling
chromatin
modifications,
DNA
methylation,
hypoxic
response,
immunity.
This
review
summarizes
by
which
abundance
different
metabolites
controls
function
fate
in
contexts.
We
will
focus
on
how
these
mediated
affect
physiology
disease.
Frontiers in Immunology,
Год журнала:
2018,
Номер
8
Опубликована: Янв. 9, 2018
The
immune
system
is
the
most
important
protective
physiological
of
organism.
It
has
many
connections
with
other
systems
and
is,
in
fact,
often
considered
as
part
larger
neuro-endocrine-immune
axis.
Most
experimental
data
on
changes
aging
show
a
decline
parameters
when
compared
to
young
healthy
subjects.
bulk
these
termed
immunosenescence.
Immunosenescence
been
for
some
time
detrimental
because
it
leads
subclinical
accumulation
proinflammatory
factors
inflamm-aging.
Together,
immunosenescence
inflamm-aging
are
suggested
stand
at
origin
diseases
elderly,
such
infections,
cancer,
autoimmune
disorders,
chronic
inflammatory
diseases.
However,
an
increasing
number
immune-gerontologists
have
challenged
this
negative
interpretation
respect
its
significance
aging-related
alterations
system.
If
one
considers
from
evolutionary
perspective,
they
can
be
viewed
preferably
adaptive
or
remodeling
rather
than
solely
detrimental.
Whereas
conceivable
that
global
may
lead
various
diseases,
also
obvious
needed
extended
survival/longevity.
Recent
cumulative
suggest
that,
without
existence
immunosenescence/inflamm-aging
duo
(representing
two
sides
same
phenomenon),
human
longevity
would
greatly
shortened.
This
review
summarizes
recent
dynamic
reassessment
aging.
Accordingly,
attempts
intervene
by
targeting
rejuvenation,
more
suitable
aim
maintain
general
homeostasis
function
appropriately
improving
immune-inflammatory-functions.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Сен. 1, 2022
Abstract
The
current
understanding
of
lactate
extends
from
its
origins
as
a
byproduct
glycolysis
to
role
in
tumor
metabolism,
identified
by
studies
on
the
Warburg
effect.
shuttle
hypothesis
suggests
that
plays
an
important
bridging
signaling
molecule
coordinates
among
different
cells,
organs
and
tissues.
Lactylation
is
posttranslational
modification
initially
reported
Professor
Yingming
Zhao’s
research
group
2019.
Subsequent
confirmed
lactylation
vital
component
function
involved
proliferation,
neural
excitation,
inflammation
other
biological
processes.
An
indispensable
substance
for
various
physiological
cellular
functions,
regulatory
aspects
energy
metabolism
signal
transduction.
Therefore,
comprehensive
review
summary
presented
clarify
disease
provide
reference
direction
future
research.
This
offers
systematic
overview
homeostasis
roles
pathological
processes,
well
effects
diseases,
particularly
cancer.
Annual Review of Immunology,
Год журнала:
2018,
Номер
36(1), С. 461 - 488
Опубликована: Апрель 20, 2018
Metabolism
drives
function,
on
both
an
organismal
and
a
cellular
level.
In
T
cell
biology,
metabolic
remodeling
is
intrinsically
linked
to
development,
activation,
differentiation,
survival.
After
naive
cells
are
activated,
increased
demands
for
currency
in
the
form
of
ATP,
as
well
biomass
growth,
proliferation,
production
effector
molecules,
met
by
rewiring
metabolism.
Consequently,
pharmacological
strategies
being
developed
perturb
or
enhance
selective
processes
that
skewed
immune-related
pathologies.
Here
we
review
most
recent
advances
describing
changes
occur
during
lifecycle.
We
discuss
how
metabolism
can
have
profound
effects
health
disease
where
it
might
be
promising
target
treat
variety
