Journal of Clinical Investigation, Год журнала: 2018, Номер 128(4), С. 1208 - 1216

Опубликована: Фев. 18, 2018

Along with a general decline in overall health, most chronic degenerative human diseases are inherently associated increasing age. Age-associated cognitive impairments and neurodegenerative diseases, such as Parkinson’s Alzheimer’s potentially debilitating conditions that lack viable options for treatment, resulting tremendous economic societal cost. Most high-profile clinical trials have led to inefficacious results, suggesting novel approaches treating these pathologies needed. Numerous recent studies demonstrated senescent cells, which characterized by sustained cell cycle arrest production of distinct senescence-associated secretory phenotype, accumulate age at sites age-related throughout the body, where they actively promote tissue deterioration. Cells features senescence been detected context brain aging disease, may also dysfunction. Here, we discuss evidence implicating cells mechanistic contribution drive neurodegeneration, how or their effects be targeted therapeutically.

Язык: Английский