Nucleic Acids Research,
Год журнала:
2020,
Номер
48(20), С. 11380 - 11393
Опубликована: Окт. 16, 2020
Advancing
the
molecular
knowledge
surrounding
fertility
and
inheritance
has
become
critical
given
halving
of
sperm
counts
in
last
40
years,
rise
complex
disease
which
cannot
be
explained
by
genetics
alone.
The
connection
between
both
these
trends
may
lie
alterations
to
epigenome
occur
through
environmental
exposures.
Changes
are
also
associated
with
health
risks
across
generations
such
as
metabolic
disorders
cancer.
Thus,
it
is
imperative
identify
epigenetic
modifications
that
escape
reprogramming
during
spermatogenesis
embryogenesis.
Here,
we
aimed
chromatin
signature(s)
involved
transgenerational
phenotypes
our
genetic
mouse
model
overexpresses
histone
demethylase
KDM1A
their
germ
cells.
We
used
sperm-specific
immunoprecipitation
followed
depth
sequencing
(ChIP-seq),
computational
analysis
whether
differential
enrichment
H3
lysine
4
trimethylation
(H3K4me3),
27
(H3K27me3)
serve
mechanisms
for
paternal
germline.
Our
on
transgenic
males
revealed
specific
changes
H3K4me3
predominantly
occurred
independently
from
bivalent
H3K4me3/H3K27me3
regions.
Many
regions
altered
were
identified
allele
pre-implantation
embryo.
These
findings
suggest
functions
transmission
non-genetic
transgenerationally.
Annual Review of Genetics,
Год журнала:
2018,
Номер
52(1), С. 131 - 157
Опубликована: Ноя. 23, 2018
PIWI-interacting
RNAs
(piRNAs)
and
their
associated
PIWI
clade
Argonaute
proteins
constitute
the
core
of
piRNA
pathway.
In
gonadal
cells,
this
conserved
pathway
is
crucial
for
genome
defense,
its
main
function
to
silence
transposable
elements.
This
achieved
through
posttranscriptional
transcriptional
gene
silencing.
Precursors
that
give
rise
piRNAs
require
specialized
transcription
transport
machineries
because
biogenesis
a
cytoplasmic
process.
The
ping-pong
cycle,
silencing
mechanism,
combines
cleavage-dependent
transposon
with
production.
also
in
nucleus,
where
they
scan
nascent
target
transcripts
sequence
complementarity,
instructing
deposition
repressive
chromatin
marks
at
loci.
Although
studies
have
revealed
numerous
factors
participate
each
branch
pathway,
precise
molecular
roles
these
often
remain
unclear.
review,
we
summarize
our
current
understanding
mechanisms
involved
function.
The
development
of
animal
embryos
is
initially
directed
by
maternal
gene
products.
Then,
during
the
maternal-to-zygotic
transition
(MZT),
developmental
control
handed
to
zygotic
genome.
Extensive
research
in
both
vertebrate
and
invertebrate
model
organisms
has
revealed
that
MZT
can
be
subdivided
into
two
phases,
which
very
different
modes
regulation
are
implemented:
initially,
exclusively
post-transcriptional
post-translational,
following
gradual
activation
genome
leads
predominance
transcriptional
regulation.
These
changes
expression
program
precisely
controlled
highly
interconnected.
Here,
we
review
current
understanding
mechanisms
underlie
handover
MZT.
Journal of Translational Medicine,
Год журнала:
2020,
Номер
18(1)
Опубликована: Дек. 1, 2020
Abstract
Aberrant
metabolism
is
the
root
cause
of
several
serious
health
issues,
creating
a
huge
burden
to
and
leading
diminished
life
expectancy.
A
dysregulated
induces
secretion
molecules
which
in
turn
trigger
inflammatory
pathway.
Inflammation
natural
reaction
immune
system
variety
stimuli,
such
as
pathogens,
damaged
cells,
harmful
substances.
Metabolically
triggered
inflammation,
also
called
metaflammation
or
low-grade
chronic
consequence
synergic
interaction
between
host
exposome—a
combination
environmental
drivers,
including
diet,
lifestyle,
pollutants
other
factors
throughout
span
an
individual.
Various
levels
inflammation
are
associated
with
lifestyle-related
diseases
diabetes,
obesity,
metabolic
fatty
liver
disease
(MAFLD),
cancers,
cardiovascular
disorders
(CVDs),
autoimmune
diseases,
lung
diseases.
Chronic
growing
concern
worldwide,
placing
heavy
on
individuals,
families,
governments,
health-care
systems.
New
strategies
needed
empower
communities
worldwide
prevent
treat
these
Precision
medicine
provides
model
for
next
generation
lifestyle
modification.
This
will
capitalize
dynamic
individual’s
biology,
behavior,
environment.
The
aim
precision
design
improve
diagnosis,
therapeutics
prognostication
through
use
large
complex
datasets
that
incorporate
individual
gene,
function,
variations.
implementation
high-performance
computing
(HPC)
artificial
intelligence
(AI)
can
predict
risks
greater
accuracy
based
available
multidimensional
clinical
biological
datasets.
AI-powered
clinicians
opportunity
specifically
tailor
early
interventions
each
In
this
article,
we
discuss
strengths
limitations
existing
evolving
recent,
data-driven
technologies,
AI,
preventing,
treating
reversing
