Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance DOI Creative Commons
Ariane Lismer, Keith Siklenka, Christine Lafleur

et al.

Nucleic Acids Research, Journal Year: 2020, Volume and Issue: 48(20), P. 11380 - 11393

Published: Oct. 16, 2020

Advancing the molecular knowledge surrounding fertility and inheritance has become critical given halving of sperm counts in last 40 years, rise complex disease which cannot be explained by genetics alone. The connection between both these trends may lie alterations to epigenome occur through environmental exposures. Changes are also associated with health risks across generations such as metabolic disorders cancer. Thus, it is imperative identify epigenetic modifications that escape reprogramming during spermatogenesis embryogenesis. Here, we aimed chromatin signature(s) involved transgenerational phenotypes our genetic mouse model overexpresses histone demethylase KDM1A their germ cells. We used sperm-specific immunoprecipitation followed depth sequencing (ChIP-seq), computational analysis whether differential enrichment H3 lysine 4 trimethylation (H3K4me3), 27 (H3K27me3) serve mechanisms for paternal germline. Our on transgenic males revealed specific changes H3K4me3 predominantly occurred independently from bivalent H3K4me3/H3K27me3 regions. Many regions altered were identified allele pre-implantation embryo. These findings suggest functions transmission non-genetic transgenerationally.

Language: Английский

Advances in epigenetics link genetics to the environment and disease DOI Open Access
Giacomo Cavalli, Édith Heard

Nature, Journal Year: 2019, Volume and Issue: 571(7766), P. 489 - 499

Published: July 1, 2019

Language: Английский

Citations

1207

Genome Regulation by Polycomb and Trithorax: 70 Years and Counting DOI Creative Commons
Bernd Schuettengruber, Henri-Marc Bourbon, Luciano Di Croce

et al.

Cell, Journal Year: 2017, Volume and Issue: 171(1), P. 34 - 57

Published: Sept. 1, 2017

Language: Английский

Citations

989

Histone post-translational modifications — cause and consequence of genome function DOI
Gonzalo Millán-Zambrano,

Adam Burton,

Andrew J. Bannister

et al.

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(9), P. 563 - 580

Published: March 25, 2022

Language: Английский

Citations

632

piRNA-Guided Genome Defense: From Biogenesis to Silencing DOI

B. Czech,

Marzia Munafò, Filippo Ciabrelli

et al.

Annual Review of Genetics, Journal Year: 2018, Volume and Issue: 52(1), P. 131 - 157

Published: Nov. 23, 2018

PIWI-interacting RNAs (piRNAs) and their associated PIWI clade Argonaute proteins constitute the core of piRNA pathway. In gonadal cells, this conserved pathway is crucial for genome defense, its main function to silence transposable elements. This achieved through posttranscriptional transcriptional gene silencing. Precursors that give rise piRNAs require specialized transcription transport machineries because biogenesis a cytoplasmic process. The ping-pong cycle, silencing mechanism, combines cleavage-dependent transposon with production. also in nucleus, where they scan nascent target transcripts sequence complementarity, instructing deposition repressive chromatin marks at loci. Although studies have revealed numerous factors participate each branch pathway, precise molecular roles these often remain unclear. review, we summarize our current understanding mechanisms involved function.

Language: Английский

Citations

494

Mechanisms regulating zygotic genome activation DOI
Katharine N. Schulz, Melissa M. Harrison

Nature Reviews Genetics, Journal Year: 2018, Volume and Issue: 20(4), P. 221 - 234

Published: Dec. 20, 2018

Language: Английский

Citations

458

Functions and mechanisms of epigenetic inheritance in animals DOI
Ksenia Skvortsova, Nicola Iovino, Ozren Bogdanović

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 19(12), P. 774 - 790

Published: Nov. 13, 2018

Language: Английский

Citations

415

The maternal-to-zygotic transition revisited DOI Open Access
Nadine L. Vastenhouw,

Wen Xi Cao,

Howard D. Lipshitz

et al.

Development, Journal Year: 2019, Volume and Issue: 146(11)

Published: June 1, 2019

The development of animal embryos is initially directed by maternal gene products. Then, during the maternal-to-zygotic transition (MZT), developmental control handed to zygotic genome. Extensive research in both vertebrate and invertebrate model organisms has revealed that MZT can be subdivided into two phases, which very different modes regulation are implemented: initially, exclusively post-transcriptional post-translational, following gradual activation genome leads predominance transcriptional regulation. These changes expression program precisely controlled highly interconnected. Here, we review current understanding mechanisms underlie handover MZT.

Language: Английский

Citations

376

Dynamics of the epigenetic landscape during the maternal-to-zygotic transition DOI
Mélanie Eckersley-Maslin, Celia Alda-Catalinas, Wolf Reik

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2018, Volume and Issue: 19(7), P. 436 - 450

Published: April 23, 2018

Language: Английский

Citations

367

Chromatin analysis in human early development reveals epigenetic transition during ZGA DOI
Jingyi Wu, Jiawei Xu, Bofeng Liu

et al.

Nature, Journal Year: 2018, Volume and Issue: 557(7704), P. 256 - 260

Published: April 30, 2018

Language: Английский

Citations

307

Precision medicine in the era of artificial intelligence: implications in chronic disease management DOI Creative Commons
Murugan Subramanian, Anne Wojtusciszyn, Lucie Favre

et al.

Journal of Translational Medicine, Journal Year: 2020, Volume and Issue: 18(1)

Published: Dec. 1, 2020

Abstract Aberrant metabolism is the root cause of several serious health issues, creating a huge burden to and leading diminished life expectancy. A dysregulated induces secretion molecules which in turn trigger inflammatory pathway. Inflammation natural reaction immune system variety stimuli, such as pathogens, damaged cells, harmful substances. Metabolically triggered inflammation, also called metaflammation or low-grade chronic consequence synergic interaction between host exposome—a combination environmental drivers, including diet, lifestyle, pollutants other factors throughout span an individual. Various levels inflammation are associated with lifestyle-related diseases diabetes, obesity, metabolic fatty liver disease (MAFLD), cancers, cardiovascular disorders (CVDs), autoimmune diseases, lung diseases. Chronic growing concern worldwide, placing heavy on individuals, families, governments, health-care systems. New strategies needed empower communities worldwide prevent treat these Precision medicine provides model for next generation lifestyle modification. This will capitalize dynamic individual’s biology, behavior, environment. The aim precision design improve diagnosis, therapeutics prognostication through use large complex datasets that incorporate individual gene, function, variations. implementation high-performance computing (HPC) artificial intelligence (AI) can predict risks greater accuracy based available multidimensional clinical biological datasets. AI-powered clinicians opportunity specifically tailor early interventions each In this article, we discuss strengths limitations existing evolving recent, data-driven technologies, AI, preventing, treating reversing

Language: Английский

Citations

233