Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

Cancer Discovery, Год журнала: 2018, Номер 8(9), С. 1069 - 1086

Опубликована: Авг. 16, 2018

Immune checkpoint blockade is able to induce durable responses across multiple types of cancer, which has enabled the oncology community begin envision potentially curative therapeutic approaches. However, remarkable immunotherapies are currently limited a minority patients and indications, highlighting need for more effective novel Indeed, an extraordinary amount preclinical clinical investigation exploring potential negative positive costimulatory molecules. Insights into underlying biological mechanisms functions these molecules have, however, lagged significantly behind. Such understanding will be essential rational design next-generation immunotherapies. Here, we review current state our T-cell blockade, primarily CTLA4 PD-1, highlight conceptual gaps in knowledge.Significance: This provides overview immune therapy from basic biology immunologic perspective cancer research community. Cancer Discov; 8(9); 1069-86. ©2018 AACR.

Язык: Английский

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Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer

Chemical Society Reviews, Год журнала: 2018, Номер 48(7), С. 2053 - 2108

Опубликована: Сен. 27, 2018

The nonradiative conversion of light energy into heat (photothermal therapy, PTT) or sound (photoacoustic imaging, PAI) has been intensively investigated for the treatment and diagnosis cancer, respectively. By taking advantage nanocarriers, both imaging therapeutic functions together with enhanced tumour accumulation have thoroughly studied to improve pre-clinical efficiency PAI PTT. In this review, we first summarize development inorganic organic nano photothermal transduction agents (PTAs) strategies improving PTT outcomes, including applying appropriate laser dosage, guiding via techniques, developing PTAs absorption in second NIR window, increasing (PCE), also tumours. Second, introduce advantages combining other therapies cancer treatment. Third, emerging applications cancer-related research are exemplified. Finally, perspectives challenges combating especially regarding their clinical translation, discussed. We believe that having noteworthy features would become promising next-generation non-invasive theranostic techniques our ability combat cancers.

Язык: Английский

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Delivery technologies for cancer immunotherapy

Nature Reviews Drug Discovery, Год журнала: 2019, Номер 18(3), С. 175 - 196

Опубликована: Янв. 8, 2019

Язык: Английский

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A view on drug resistance in cancer

Nature, Год журнала: 2019, Номер 575(7782), С. 299 - 309

Опубликована: Ноя. 13, 2019

Язык: Английский

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TISIDB: an integrated repository portal for tumor–immune system interactions

Bioinformatics, Год журнала: 2019, Номер 35(20), С. 4200 - 4202

Опубликована: Март 20, 2019

The interaction between tumor and immune system plays a crucial role in both cancer development treatment response. To facilitate comprehensive investigation of tumor-immune interactions, we have designed user-friendly web portal TISIDB, which integrated multiple types data resources oncoimmunology. First, manually curated 4176 records from 2530 publications, reported 988 genes related to anti-tumor immunity. Second, associated with the resistance or sensitivity cells T cell-mediated killing immunotherapy were identified by analyzing high-throughput screening genomic profiling data. Third, associations any gene features, such as lymphocytes, immunomodulators chemokines, pre-calculated for 30 TCGA types. In biologists can cross-check interest about its interactions through literature mining analysis, generate testable hypotheses high quality figures publication.http://cis.hku.hk/TISIDB.Supplementary are available at Bioinformatics online.

Язык: Английский

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Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance

Annual Review of Pathology Mechanisms of Disease, Год журнала: 2020, Номер 16(1), С. 223 - 249

Опубликована: Ноя. 16, 2020

Immune checkpoint inhibitors (ICIs) have made an indelible mark in the field of cancer immunotherapy. Starting with approval anti-cytotoxic T lymphocyte-associated protein 4 (anti-CTLA-4) for advanced-stage melanoma 2011, ICIs-which now also include antibodies against programmed cell death 1 (PD-1) and its ligand (PD-L1)-quickly gained US Food Drug Administration treatment a wide array types, demonstrating unprecedented extension patient survival. However, despite success ICIs, resistance to these agents restricts number patients able achieve durable responses, immune-related adverse events complicate treatment. Thus, better understanding requirements effective safe antitumor immune response following ICI therapy is needed. Studies both tumoral systemic changes system yielded insight into basis efficacy resistance. Ultimately, by building on insights, researchers should be combine ICIs other agents, or design new immunotherapies, broader more as well greater safety. Here, we review history clinical utility mechanisms therapy, local associated outcome.

Язык: Английский

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CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

Annual Review of Immunology, Год журнала: 2019, Номер 37(1), С. 457 - 495

Опубликована: Янв. 24, 2019

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections and cancers in animal models humans. Tex characterized by progressive loss of effector functions, high sustained inhibitory receptor expression, metabolic dysregulation, poor memory recall homeostatic self-renewal, transcriptional epigenetic programs. The ability to reinvigorate through blockade, such as αPD-1, highlights the therapeutic potential targeting this population. Emerging insights into mechanisms exhaustion informing immunotherapies for cancer infections. However, like other immune cells, heterogeneous include progenitor terminal subsets with unique characteristics responses checkpoint blockade. Here, we review our current understanding biology, including developmental paths, features, intrinsic extrinsic factors contributing how knowledge may inform infections, autoimmunity, cancer.

Язык: Английский

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Tertiary lymphoid structures in the era of cancer immunotherapy

Nature reviews. Cancer, Год журнала: 2019, Номер 19(6), С. 307 - 325

Опубликована: Май 15, 2019

Язык: Английский

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Tumor microenvironment as a therapeutic target in cancer

Pharmacology & Therapeutics, Год журнала: 2020, Номер 221, С. 107753 - 107753

Опубликована: Ноя. 28, 2020

Язык: Английский

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Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

Immunity, Год журнала: 2019, Номер 50(1), С. 195 - 211.e10

Опубликована: Янв. 1, 2019

Язык: Английский

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