A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice

Cell, Год журнала: 2018, Номер 174(2), С. 481 - 496.e19

Опубликована: Июль 1, 2018

Язык: Английский

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Dissociable dopamine dynamics for learning and motivation

Nature, Год журнала: 2019, Номер 570(7759), С. 65 - 70

Опубликована: Май 22, 2019

Язык: Английский

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A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine

Neuron, Год журнала: 2019, Номер 102(4), С. 745 - 761.e8

Опубликована: Март 25, 2019

Язык: Английский

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A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Neuron, Год журнала: 2018, Номер 101(1), С. 133 - 151.e7

Опубликована: Ноя. 29, 2018

Язык: Английский

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Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks

Chemical Reviews, Год журнала: 2018, Номер 118(24), С. 11707 - 11794

Опубликована: Дек. 14, 2018

Cellular signaling networks are the foundation which determines fate and function of cells as they respond to various cues stimuli. The discovery fluorescent proteins over 25 years ago enabled development a diverse array genetically encodable biosensors that capable measuring spatiotemporal dynamics signal transduction pathways in live cells. In an effort encapsulate breadth have expanded, we endeavored assemble comprehensive list published engineered biosensors, discuss many molecular designs utilized their development. Then, review how high temporal spatial resolution afforded by has aided our understanding regulation at cellular subcellular level. Finally, highlight some emerging areas research both biosensor design applications on forefront

Язык: Английский

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Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Nature Methods, Год журнала: 2020, Номер 17(11), С. 1156 - 1166

Опубликована: Окт. 21, 2020

Язык: Английский

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Disruption of mitochondrial complex I induces progressive parkinsonism

Nature, Год журнала: 2021, Номер 599(7886), С. 650 - 656

Опубликована: Ноя. 3, 2021

Язык: Английский

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The transition to compulsion in addiction

Nature reviews. Neuroscience, Год журнала: 2020, Номер 21(5), С. 247 - 263

Опубликована: Март 30, 2020

Язык: Английский

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Variable‐Temperature Electron Transport and Dipole Polarization Turning Flexible Multifunctional Microsensor beyond Electrical and Optical Energy

Advanced Materials, Год журнала: 2020, Номер 32(10)

Опубликована: Янв. 29, 2020

Abstract Humans are undergoing a fateful transformation focusing on artificial intelligence, quantum information technology, virtual reality, etc., which is inseparable from intelligent nano–micro devices. However, the booming of “Big Data” brings about an even greater challenge by growing electromagnetic radiation. Herein, innovative flexible multifunctional microsensor proposed, opening up new horizon for It integrates “non‐crosstalk” multiple perception and green interference shielding only in one pixel, with satisfactory sensitivity fast feedback. Importantly, beneficial deep insight into variable‐temperature response, tactfully transforms urgent threat radiation “wealth,” further integrating self‐power. This result will refresh researchers' realization next‐generation devices, ushering direction aerospace engineering, remote sensing, communications, medical treatment, biomimetic robot, prosthetics, etc.

Язык: Английский

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An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

Nature Methods, Год журнала: 2020, Номер 17(11), С. 1139 - 1146

Опубликована: Сен. 28, 2020

Язык: Английский

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