A Genetically Encoded Fluorescent Sensor Enables Rapid and Specific Detection of Dopamine in Flies, Fish, and Mice

Cell, Journal Year: 2018, Volume and Issue: 174(2), P. 481 - 496.e19

Published: July 1, 2018

Language: Английский

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Dissociable dopamine dynamics for learning and motivation

Nature, Journal Year: 2019, Volume and Issue: 570(7759), P. 65 - 70

Published: May 22, 2019

Language: Английский

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A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine

Neuron, Journal Year: 2019, Volume and Issue: 102(4), P. 745 - 761.e8

Published: March 25, 2019

Language: Английский

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A Neural Circuit Mechanism for Encoding Aversive Stimuli in the Mesolimbic Dopamine System

Neuron, Journal Year: 2018, Volume and Issue: 101(1), P. 133 - 151.e7

Published: Nov. 29, 2018

Language: Английский

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Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks

Chemical Reviews, Journal Year: 2018, Volume and Issue: 118(24), P. 11707 - 11794

Published: Dec. 14, 2018

Cellular signaling networks are the foundation which determines fate and function of cells as they respond to various cues stimuli. The discovery fluorescent proteins over 25 years ago enabled development a diverse array genetically encodable biosensors that capable measuring spatiotemporal dynamics signal transduction pathways in live cells. In an effort encapsulate breadth have expanded, we endeavored assemble comprehensive list published engineered biosensors, discuss many molecular designs utilized their development. Then, review how high temporal spatial resolution afforded by has aided our understanding regulation at cellular subcellular level. Finally, highlight some emerging areas research both biosensor design applications on forefront

Language: Английский

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Next-generation GRAB sensors for monitoring dopaminergic activity in vivo

Nature Methods, Journal Year: 2020, Volume and Issue: 17(11), P. 1156 - 1166

Published: Oct. 21, 2020

Language: Английский

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Disruption of mitochondrial complex I induces progressive parkinsonism

Nature, Journal Year: 2021, Volume and Issue: 599(7886), P. 650 - 656

Published: Nov. 3, 2021

Language: Английский

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The transition to compulsion in addiction

Nature reviews. Neuroscience, Journal Year: 2020, Volume and Issue: 21(5), P. 247 - 263

Published: March 30, 2020

Language: Английский

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Variable‐Temperature Electron Transport and Dipole Polarization Turning Flexible Multifunctional Microsensor beyond Electrical and Optical Energy

Advanced Materials, Journal Year: 2020, Volume and Issue: 32(10)

Published: Jan. 29, 2020

Abstract Humans are undergoing a fateful transformation focusing on artificial intelligence, quantum information technology, virtual reality, etc., which is inseparable from intelligent nano–micro devices. However, the booming of “Big Data” brings about an even greater challenge by growing electromagnetic radiation. Herein, innovative flexible multifunctional microsensor proposed, opening up new horizon for It integrates “non‐crosstalk” multiple perception and green interference shielding only in one pixel, with satisfactory sensitivity fast feedback. Importantly, beneficial deep insight into variable‐temperature response, tactfully transforms urgent threat radiation “wealth,” further integrating self‐power. This result will refresh researchers' realization next‐generation devices, ushering direction aerospace engineering, remote sensing, communications, medical treatment, biomimetic robot, prosthetics, etc.

Language: Английский

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An optimized acetylcholine sensor for monitoring in vivo cholinergic activity

Nature Methods, Journal Year: 2020, Volume and Issue: 17(11), P. 1139 - 1146

Published: Sept. 28, 2020

Language: Английский

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