Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

Molecular Cell, Год журнала: 2019, Номер 74(4), С. 640 - 650

Опубликована: Май 1, 2019

Язык: Английский

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Functions of N6-methyladenosine and its role in cancer

Molecular Cancer, Год журнала: 2019, Номер 18(1)

Опубликована: Дек. 1, 2019

N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A installed by methyltransferases, removed demethylases recognized reader proteins, regulate RNA metabolism including translation, splicing, export, degradation microRNA processing. Alteration levels participates cancer pathogenesis development via expression tumor-related genes like BRD4, MYC, SOCS2 EGFR. In this review, we elaborate recent advances research enzymes. We also highlight underlying mechanism progression. Finally, review corresponding potential targets therapy.

Язык: Английский

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m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

Cancer Cell, Год журнала: 2020, Номер 37(3), С. 270 - 288

Опубликована: Март 1, 2020

Язык: Английский

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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Cancer Cell, Год журнала: 2020, Номер 38(1), С. 79 - 96.e11

Опубликована: Июнь 11, 2020

Язык: Английский

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N ⁶ -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Science, Год журнала: 2020, Номер 367(6477), С. 580 - 586

Опубликована: Янв. 17, 2020

A new layer of transcriptional control N 6 -methyladenosine (m A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) mammalian cells. Disruption these increases their abundance and promotes gene transcription by increasing chromatin accessibility. Thus, serves as a switch to regulate carRNA levels tuning nearby state downstream transcription. Science , this issue p. 580

Язык: Английский

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Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA

Molecular Cell, Год журнала: 2019, Номер 74(6), С. 1304 - 1316.e8

Опубликована: Апрель 25, 2019

Язык: Английский

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Small RNAs are modified with N-glycans and displayed on the surface of living cells

Cell, Год журнала: 2021, Номер 184(12), С. 3109 - 3124.e22

Опубликована: Май 17, 2021

Язык: Английский

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The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

Molecular Cancer, Год журнала: 2021, Номер 20(1)

Опубликована: Янв. 18, 2021

Abstract RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances been made in understanding the functional role regulating coding and non-coding processing function, which turn thoroughly shape distinct They affect diverse biological processes, correct deposition many these is required for normal development. Alterations their are implicated several diseases, including cancer. In this Review, we focus on occurrence N 6 -methyladenosine (m A), 5-methylcytosine 5 C) pseudouridine (Ψ) RNAs describe physiopathological We will highlight latest insights into mechanisms how influence tumour development, maintenance, progression. Finally, summarize development small molecule inhibitors that target specific writers or erasers to rewind epitranscriptome a cancer cell therapeutic potential.

Язык: Английский

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N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

Nature Chemical Biology, Год журнала: 2018, Номер 15(1), С. 88 - 94

Опубликована: Дек. 4, 2018

Язык: Английский

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Cap-specific terminal N ⁶ -methylation of RNA by an RNA polymerase II–associated methyltransferase

Science, Год журнала: 2018, Номер 363(6423)

Опубликована: Ноя. 23, 2018

A cap-specific m 6 writer N ,2′- O -dimethyladenosine (m Am) is present at the transcription start nucleotide of capped mRNAs in vertebrates. Akichika et al. quantified abundance this modification transcriptome and identified protein, adenosine methyltransferase (CAPAM), needed for modification. CAPAM contains a unique structure that recognizes -methyladenosine A) as substrate. The protein interacts with RNA polymerase II, suggesting occurs cotranscriptionally. Am promotes translation eIF4E-independent fashion. Science , issue p. eaav0080

Язык: Английский

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