N6-Methyladenosine co-transcriptionally directs the demethylation of histone H3K9me2 DOI
Yuan Li, Linjian Xia,

Kaifen Tan

et al.

Nature Genetics, Journal Year: 2020, Volume and Issue: 52(9), P. 870 - 877

Published: Aug. 10, 2020

Language: Английский

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers DOI Creative Commons
Hailing Shi, Jiangbo Wei, Chuan He

et al.

Molecular Cell, Journal Year: 2019, Volume and Issue: 74(4), P. 640 - 650

Published: May 1, 2019

Language: Английский

Citations

1474
Functions of N6-methyladenosine and its role in cancer DOI Creative Commons

Liuer He,

Huiyu Li,

Anqi Wu

et al.

Molecular Cancer, Journal Year: 2019, Volume and Issue: 18(1)

Published: Dec. 1, 2019

N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A installed by methyltransferases, removed demethylases recognized reader proteins, regulate RNA metabolism including translation, splicing, export, degradation microRNA processing. Alteration levels participates cancer pathogenesis development via expression tumor-related genes like BRD4, MYC, SOCS2 EGFR. In this review, we elaborate recent advances research enzymes. We also highlight underlying mechanism progression. Finally, review corresponding potential targets therapy.

Language: Английский

Citations

1092
m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer DOI Creative Commons
Huilin Huang, Hengyou Weng, Jianjun Chen

et al.

Cancer Cell, Journal Year: 2020, Volume and Issue: 37(3), P. 270 - 288

Published: March 1, 2020

Language: Английский

Citations

935
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion DOI Creative Commons
Rui Su, Lei Dong, Yangchan Li

et al.

Cancer Cell, Journal Year: 2020, Volume and Issue: 38(1), P. 79 - 96.e11

Published: June 11, 2020

Language: Английский

Citations

583
N 6 -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription DOI Open Access
Jun Liu, Xiaoyang Dou, Chuanyuan Chen

et al.

Science, Journal Year: 2020, Volume and Issue: 367(6477), P. 580 - 586

Published: Jan. 17, 2020

A new layer of transcriptional control N 6 -methyladenosine (m A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) mammalian cells. Disruption these increases their abundance and promotes gene transcription by increasing chromatin accessibility. Thus, serves as a switch to regulate carRNA levels tuning nearby state downstream transcription. Science , this issue p. 580

Language: Английский

Citations

535
Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA DOI Creative Commons
Lisheng Zhang, Chang Liu, Honghui Ma

et al.

Molecular Cell, Journal Year: 2019, Volume and Issue: 74(6), P. 1304 - 1316.e8

Published: April 25, 2019

Language: Английский

Citations

407
Small RNAs are modified with N-glycans and displayed on the surface of living cells DOI Creative Commons
Ryan A. Flynn, Kayvon Pedram, Stacy A. Malaker

et al.

Cell, Journal Year: 2021, Volume and Issue: 184(12), P. 3109 - 3124.e22

Published: May 17, 2021

Language: Английский

Citations

403
The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities DOI Creative Commons

Paz Nombela,

Borja Miguel‐López, Sandra Blanco

et al.

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: Jan. 18, 2021

Abstract RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances been made in understanding the functional role regulating coding and non-coding processing function, which turn thoroughly shape distinct They affect diverse biological processes, correct deposition many these is required for normal development. Alterations their are implicated several diseases, including cancer. In this Review, we focus on occurrence N 6 -methyladenosine (m A), 5-methylcytosine 5 C) pseudouridine (Ψ) RNAs describe physiopathological We will highlight latest insights into mechanisms how influence tumour development, maintenance, progression. Finally, summarize development small molecule inhibitors that target specific writers or erasers to rewind epitranscriptome a cancer cell therapeutic potential.

Language: Английский

Citations

356
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation DOI
Honghui Ma, Xiaoyun Wang, Jia‐Bin Cai

et al.

Nature Chemical Biology, Journal Year: 2018, Volume and Issue: 15(1), P. 88 - 94

Published: Dec. 4, 2018

Language: Английский

Citations

341
Cap-specific terminal N 6 -methylation of RNA by an RNA polymerase II–associated methyltransferase DOI Open Access
Shinichiro Akichika, Seiichi Hirano, Yuichi Shichino

et al.

Science, Journal Year: 2018, Volume and Issue: 363(6423)

Published: Nov. 23, 2018

A cap-specific m 6 writer N ,2′- O -dimethyladenosine (m Am) is present at the transcription start nucleotide of capped mRNAs in vertebrates. Akichika et al. quantified abundance this modification transcriptome and identified protein, adenosine methyltransferase (CAPAM), needed for modification. CAPAM contains a unique structure that recognizes -methyladenosine A) as substrate. The protein interacts with RNA polymerase II, suggesting occurs cotranscriptionally. Am promotes translation eIF4E-independent fashion. Science , issue p. eaav0080

Language: Английский

Citations

321