Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

Molecular Cell, Journal Year: 2019, Volume and Issue: 74(4), P. 640 - 650

Published: May 1, 2019

Language: Английский

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Functions of N6-methyladenosine and its role in cancer

Molecular Cancer, Journal Year: 2019, Volume and Issue: 18(1)

Published: Dec. 1, 2019

N6-methyladenosine (m6A) is methylation that occurs in the N6-position of adenosine, which most prevalent internal modification on eukaryotic mRNA. Accumulating evidence suggests m6A modulates gene expression, thereby regulating cellular processes ranging from cell self-renewal, differentiation, invasion and apoptosis. M6A installed by methyltransferases, removed demethylases recognized reader proteins, regulate RNA metabolism including translation, splicing, export, degradation microRNA processing. Alteration levels participates cancer pathogenesis development via expression tumor-related genes like BRD4, MYC, SOCS2 EGFR. In this review, we elaborate recent advances research enzymes. We also highlight underlying mechanism progression. Finally, review corresponding potential targets therapy.

Language: Английский

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m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

Cancer Cell, Journal Year: 2020, Volume and Issue: 37(3), P. 270 - 288

Published: March 1, 2020

Language: Английский

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Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion

Cancer Cell, Journal Year: 2020, Volume and Issue: 38(1), P. 79 - 96.e11

Published: June 11, 2020

Language: Английский

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N ⁶ -methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription

Science, Journal Year: 2020, Volume and Issue: 367(6477), P. 580 - 586

Published: Jan. 17, 2020

A new layer of transcriptional control N 6 -methyladenosine (m A) is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs) mammalian cells. Disruption these increases their abundance and promotes gene transcription by increasing chromatin accessibility. Thus, serves as a switch to regulate carRNA levels tuning nearby state downstream transcription. Science , this issue p. 580

Language: Английский

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Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA

Molecular Cell, Journal Year: 2019, Volume and Issue: 74(6), P. 1304 - 1316.e8

Published: April 25, 2019

Language: Английский

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Small RNAs are modified with N-glycans and displayed on the surface of living cells

Cell, Journal Year: 2021, Volume and Issue: 184(12), P. 3109 - 3124.e22

Published: May 17, 2021

Language: Английский

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The role of m6A, m5C and Ψ RNA modifications in cancer: Novel therapeutic opportunities

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: Jan. 18, 2021

Abstract RNA modifications have recently emerged as critical posttranscriptional regulators of gene expression programmes. Significant advances been made in understanding the functional role regulating coding and non-coding processing function, which turn thoroughly shape distinct They affect diverse biological processes, correct deposition many these is required for normal development. Alterations their are implicated several diseases, including cancer. In this Review, we focus on occurrence N 6 -methyladenosine (m A), 5-methylcytosine 5 C) pseudouridine (Ψ) RNAs describe physiopathological We will highlight latest insights into mechanisms how influence tumour development, maintenance, progression. Finally, summarize development small molecule inhibitors that target specific writers or erasers to rewind epitranscriptome a cancer cell therapeutic potential.

Language: Английский

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N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

Nature Chemical Biology, Journal Year: 2018, Volume and Issue: 15(1), P. 88 - 94

Published: Dec. 4, 2018

Language: Английский

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Epigenetic regulation of aging: implications for interventions of aging and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Nov. 7, 2022

Abstract Aging is accompanied by the decline of organismal functions and a series prominent hallmarks, including genetic epigenetic alterations. These aging-associated changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA (ncRNA) regulation, all which participate in regulation aging process, hence contribute to aging-related diseases. Therefore, understanding mechanisms will provide new avenues develop strategies delay aging. Indeed, interventions based on manipulating have led alleviation or extension lifespan animal models. Small molecule-based therapies reprogramming that enable rejuvenation been developed for ameliorating reversing conditions. In addition, adopting health-promoting activities, such as caloric restriction, exercise, calibrating circadian rhythm, has demonstrated Furthermore, various clinical trials intervention are ongoing, providing more evidence safety efficacy these therapies. Here, we review recent work outline advances age-associated A better critical roles epigenetics process lead prevention human therapy

Language: Английский

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