Nature Protocols, Год журнала: 2021, Номер 17(1), С. 129 - 151
Опубликована: Дек. 24, 2021
Язык: Английский
Nature Protocols, Год журнала: 2021, Номер 17(1), С. 129 - 151
Опубликована: Дек. 24, 2021
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2020, Номер 5(1)
Опубликована: Март 12, 2020
Abstract Metastasis is the hallmark of cancer that responsible for greatest number cancer-related deaths. Yet, it remains poorly understood. The continuous evolution biology research and emergence new paradigms in study metastasis have revealed some molecular underpinnings this dissemination process. invading tumor cell, on its way to target site, interacts with other proteins cells. Recognition these interactions improved understanding biological principles metastatic cell govern mobility plasticity. Communication microenvironment allows cells overcome stromal challenges, settle, colonize. These characteristics are driven by genetic epigenetic modifications within itself microenvironment. Establishing mechanisms process crucial finding open therapeutic windows successful interventions. In review, authors explore recent advancements field highlight latest insights contribute shaping cancer.
Язык: Английский
Процитировано
1828Science, Год журнала: 2020, Номер 368(6487)
Опубликована: Апрель 9, 2020
Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but not yet resulted an effective anti therapeutic. In a Review, Faubert et al. discuss how changes develops from small, premalignant lesion to aggressive primary tumor and then metastasizes. Metabolic vulnerabilities likely change with progression, making the identification of general cancer-associated metabolic features difficult. The authors propose that more targeted approach tissues patients may be effective. Science , this issue p. eaaw5473
Язык: Английский
Процитировано
1750Nature, Год журнала: 2020, Номер 585(7823), С. 113 - 118
Опубликована: Авг. 19, 2020
Язык: Английский
Процитировано
716Nature reviews. Cancer, Год журнала: 2021, Номер 21(3), С. 162 - 180
Опубликована: Янв. 18, 2021
Язык: Английский
Процитировано
687Nature Reviews Drug Discovery, Год журнала: 2020, Номер 19(7), С. 480 - 494
Опубликована: Июнь 17, 2020
Язык: Английский
Процитировано
620Cell, Год журнала: 2020, Номер 182(2), С. 270 - 296
Опубликована: Июль 1, 2020
Язык: Английский
Процитировано
532Advanced Drug Delivery Reviews, Год журнала: 2020, Номер 159, С. 245 - 293
Опубликована: Янв. 1, 2020
With the advent of effective tools to study lipids, including mass spectrometry-based lipidomics, lipids are emerging as central players in cancer biology. Lipids function essential building blocks for membranes, serve fuel drive energy-demanding processes and play a key role signaling molecules regulators numerous cellular functions. Not unexpectedly, cells, well other cell types tumor microenvironment, exploit various ways acquire extensively rewire their metabolism part plastic context-dependent metabolic reprogramming that is driven by both oncogenic environmental cues. The resulting changes fate composition help cells thrive changing microenvironment supporting functions hallmarks, energetics, promoting feedforward signaling, resisting oxidative stresses, regulating intercellular communication immune responses. Supported close connection between altered lipid pathogenic process, specific profiles unique disease biomarkers, with diagnostic, prognostic predictive potential. Multiple preclinical studies illustrate translational promise exploiting cancer, critically, have shown context dependent actionable vulnerabilities can be rationally targeted, particularly combinatorial approaches. Moreover, themselves used membrane disrupting agents or components nanocarriers therapeutics. number compounds strategies approaching clinical trials, we at doorstep hitherto underappreciated hallmark promising target oncologist's strategy combat cancer.
Язык: Английский
Процитировано
478Developmental Cell, Год журнала: 2021, Номер 56(10), С. 1363 - 1393
Опубликована: Май 1, 2021
Язык: Английский
Процитировано
428Cells, Год журнала: 2020, Номер 9(10), С. 2308 - 2308
Опубликована: Окт. 16, 2020
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, stem cells. Well-known oncogenic signaling phosphoinositide 3-kinase (PI3K)/AKT, Myc, Hippo pathway, mediate metabolic gene expression increase enzyme activities. Vice versa, deregulated pathways contribute to defects cellular signal transduction which turn provide energy, building blocks, redox potentials for unrestrained cell proliferation. Studies clinical trials are being performed that focus on the inhibition enzymes by small molecules or dietary interventions (e.g., fasting, calorie restriction, intermittent fasting). Similar genetic heterogeneity, phenotypes cancers highly heterogeneous. This heterogeneity results from diverse cues tumor microenvironment mutations. Hence, overcoming plasticity an goal modern therapeutics. review highlights recent findings elucidates interactions between pathways. We also novel rationales designing next-generation drugs.
Язык: Английский
Процитировано
410Cell, Год журнала: 2023, Номер 186(8), С. 1564 - 1579
Опубликована: Апрель 1, 2023
Язык: Английский
Процитировано
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