Molecular principles of metastasis: a hallmark of cancer revisited

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: March 12, 2020

Abstract Metastasis is the hallmark of cancer that responsible for greatest number cancer-related deaths. Yet, it remains poorly understood. The continuous evolution biology research and emergence new paradigms in study metastasis have revealed some molecular underpinnings this dissemination process. invading tumor cell, on its way to target site, interacts with other proteins cells. Recognition these interactions improved understanding biological principles metastatic cell govern mobility plasticity. Communication microenvironment allows cells overcome stromal challenges, settle, colonize. These characteristics are driven by genetic epigenetic modifications within itself microenvironment. Establishing mechanisms process crucial finding open therapeutic windows successful interventions. In review, authors explore recent advancements field highlight latest insights contribute shaping cancer.

Language: Английский

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Metabolic reprogramming and cancer progression

Science, Journal Year: 2020, Volume and Issue: 368(6487)

Published: April 9, 2020

Metabolism as cancer progresses Numerous cancer-specific alterations in metabolism have been identified but not yet resulted an effective anti therapeutic. In a Review, Faubert et al. discuss how changes develops from small, premalignant lesion to aggressive primary tumor and then metastasizes. Metabolic vulnerabilities likely change with progression, making the identification of general cancer-associated metabolic features difficult. The authors propose that more targeted approach tissues patients may be effective. Science , this issue p. eaaw5473

Language: Английский

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Lymph protects metastasizing melanoma cells from ferroptosis

Nature, Journal Year: 2020, Volume and Issue: 585(7823), P. 113 - 118

Published: Aug. 19, 2020

Language: Английский

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The metabolism of cancer cells during metastasis

Nature reviews. Cancer, Journal Year: 2021, Volume and Issue: 21(3), P. 162 - 180

Published: Jan. 18, 2021

Language: Английский

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Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine

Nature Reviews Drug Discovery, Journal Year: 2020, Volume and Issue: 19(7), P. 480 - 494

Published: June 17, 2020

Language: Английский

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The Lymphatic Vasculature in the 21st Century: Novel Functional Roles in Homeostasis and Disease

Cell, Journal Year: 2020, Volume and Issue: 182(2), P. 270 - 296

Published: July 1, 2020

Language: Английский

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Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention

Advanced Drug Delivery Reviews, Journal Year: 2020, Volume and Issue: 159, P. 245 - 293

Published: Jan. 1, 2020

With the advent of effective tools to study lipids, including mass spectrometry-based lipidomics, lipids are emerging as central players in cancer biology. Lipids function essential building blocks for membranes, serve fuel drive energy-demanding processes and play a key role signaling molecules regulators numerous cellular functions. Not unexpectedly, cells, well other cell types tumor microenvironment, exploit various ways acquire extensively rewire their metabolism part plastic context-dependent metabolic reprogramming that is driven by both oncogenic environmental cues. The resulting changes fate composition help cells thrive changing microenvironment supporting functions hallmarks, energetics, promoting feedforward signaling, resisting oxidative stresses, regulating intercellular communication immune responses. Supported close connection between altered lipid pathogenic process, specific profiles unique disease biomarkers, with diagnostic, prognostic predictive potential. Multiple preclinical studies illustrate translational promise exploiting cancer, critically, have shown context dependent actionable vulnerabilities can be rationally targeted, particularly combinatorial approaches. Moreover, themselves used membrane disrupting agents or components nanocarriers therapeutics. number compounds strategies approaching clinical trials, we at doorstep hitherto underappreciated hallmark promising target oncologist's strategy combat cancer.

Language: Английский

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Lipid metabolism in cancer: New perspectives and emerging mechanisms

Developmental Cell, Journal Year: 2021, Volume and Issue: 56(10), P. 1363 - 1393

Published: May 1, 2021

Language: Английский

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Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

Cells, Journal Year: 2020, Volume and Issue: 9(10), P. 2308 - 2308

Published: Oct. 16, 2020

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, stem cells. Well-known oncogenic signaling phosphoinositide 3-kinase (PI3K)/AKT, Myc, Hippo pathway, mediate metabolic gene expression increase enzyme activities. Vice versa, deregulated pathways contribute to defects cellular signal transduction which turn provide energy, building blocks, redox potentials for unrestrained cell proliferation. Studies clinical trials are being performed that focus on the inhibition enzymes by small molecules or dietary interventions (e.g., fasting, calorie restriction, intermittent fasting). Similar genetic heterogeneity, phenotypes cancers highly heterogeneous. This heterogeneity results from diverse cues tumor microenvironment mutations. Hence, overcoming plasticity an goal modern therapeutics. review highlights recent findings elucidates interactions between pathways. We also novel rationales designing next-generation drugs.

Language: Английский

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Metastasis

Cell, Journal Year: 2023, Volume and Issue: 186(8), P. 1564 - 1579

Published: April 1, 2023

Language: Английский

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