Science,
Год журнала:
2024,
Номер
383(6690), С. 1478 - 1483
Опубликована: Март 28, 2024
Experiences
need
to
be
tagged
during
learning
for
further
consolidation.
However,
neurophysiological
mechanisms
that
select
experiences
lasting
memory
are
not
known.
By
combining
large-scale
neural
recordings
in
mice
with
dimensionality
reduction
techniques,
we
observed
successive
maze
traversals
were
tracked
by
continuously
drifting
populations
of
neurons,
providing
neuronal
signatures
both
places
visited
and
events
encountered.
When
the
brain
state
changed
reward
consumption,
sharp
wave
ripples
(SPW-Rs)
occurred
on
some
trials,
their
specific
spike
content
decoded
trial
blocks
surrounded
them.
During
postexperience
sleep,
SPW-Rs
continued
replay
those
reactivated
most
frequently
waking
SPW-Rs.
Replay
awake
may
thus
provide
a
tagging
mechanism
aspects
experience
preserved
consolidated
future
use.
Nature,
Год журнала:
2022,
Номер
609(7926), С. 327 - 334
Опубликована: Авг. 24, 2022
Abstract
In
the
hippocampus,
spatial
maps
are
formed
by
place
cells
while
contextual
memories
thought
to
be
encoded
as
engrams
1–6
.
Engrams
typically
identified
expression
of
immediate
early
gene
Fos
,
but
little
is
known
about
neural
activity
patterns
that
drive,
and
shaped
by,
in
behaving
animals
7–10
Thus,
it
unclear
whether
Fos-expressing
hippocampal
neurons
also
encode
correlates
with
affects
specific
features
code
11
Here
we
measured
CA1
calcium
imaging
monitoring
induction
mice
performing
a
hippocampus-dependent
learning
task
virtual
reality.
We
find
high
form
ensembles
highly
correlated
activity,
exhibit
reliable
fields
evenly
tile
environment
have
more
stable
tuning
across
days
than
nearby
non-Fos-induced
cells.
Comparing
neighbouring
without
function
using
sparse
genetic
loss-of-function
approach,
disrupted
less
decreased
selectivity
lower
across-day
stability.
Our
results
demonstrate
Fos-induced
contribute
codes
encoding
accurate,
spatially
uniform
itself
has
causal
role
shaping
these
codes.
may
therefore
link
two
key
aspects
function:
for
underlie
cognitive
maps.
Molecular Psychiatry,
Год журнала:
2022,
Номер
27(8), С. 3119 - 3128
Опубликована: Май 18, 2022
Abstract
How
does
cognition
regulate
innate
behaviors?
While
the
cognitive
functions
of
cortex
have
been
extensively
studied,
we
know
much
less
about
how
can
motivated
behaviors
to
fulfill
physiological,
safety
and
social
needs.
Selection
appropriate
depends
on
external
stimuli
past
experiences
that
helps
scale
priorities.
With
its
abundant
inputs
from
neocortical
allocortical
regions,
lateral
septum
(LS)
is
ideally
positioned
integrate
perception
experience
signals
in
order
activity
hypothalamic
midbrain
nuclei
control
behaviors.
In
addition,
LS
receives
numerous
subcortical
modulatory
inputs,
which
represent
animal
internal
states
also
participate
this
regulation.
perspective,
argue
sub-circuits
distinct
by
integrating
neural
neocortical,
neuromodulatory
inputs.
propose
inhibition
between
may
allow
emergence
functional
units
orchestrates
competing
Neuron,
Год журнала:
2022,
Номер
110(17), С. 2790 - 2801.e5
Опубликована: Июль 8, 2022
Learning
and
consolidation
of
new
motor
skills
require
plasticity
in
the
cortex
striatum,
two
key
regions
brain.
However,
how
neurons
undergo
synaptic
changes
become
recruited
during
learning
to
form
a
memory
engram
remains
unknown.
Here,
we
train
mice
on
task
use
genetic
approach
identify
manipulate
behavior-relevant
selectively
primary
(M1).
We
find
that
degree
M1
neuron
reactivation
correlates
with
performance.
further
demonstrate
learning-induced
dendritic
spine
reorganization
specifically
occurs
these
neurons.
In
addition,
leads
an
increase
strength
outputs
onto
striatal
spiny
projection
(SPNs)
synapses
clusters
along
SPN
dendrites.
These
results
highly
specific
formation
long-lasting
traces
corticostriatal
circuit.
Neuron,
Год журнала:
2022,
Номер
110(8), С. 1416 - 1431.e13
Опубликована: Фев. 8, 2022
The
empathic
ability
to
vicariously
experience
the
other's
fearful
situation,
a
process
called
observational
fear
(OF),
is
critical
survive
in
nature
and
function
society.
OF
can
be
facilitated
by
both
prior
similar
observer
social
familiarity
with
demonstrator.
However,
neural
circuit
mechanisms
of
experience-dependent
(Exp
OF)
remain
unknown.
Here,
we
demonstrate
that
hippocampal-basolateral
amygdala
(HPC-BLA)
circuits
mice
without
involving
anterior
cingulate
cortex,
considered
center
OF,
mediate
Exp
OF.
Dorsal
HPC
neurons
generate
memory
engram
cells
BLA
encoding
experiences,
which
are
essential
for
On
other
hand,
ventral
respond
familiar
demonstrator's
aversive
situation
during
reactivates
elicit
Our
study
provides
new
insights
into
engram-dependent
perception-action
coupling
underlies
behaviors
like
