A positively tuned voltage indicator for extended electrical recordings in the brain

Nature Methods, Год журнала: 2023, Номер 20(7), С. 1104 - 1113

Опубликована: Июль 1, 2023

Язык: Английский

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Cortico-basal ganglia plasticity in motor learning

Neuron, Год журнала: 2024, Номер 112(15), С. 2486 - 2502

Опубликована: Июль 12, 2024

Язык: Английский

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Genetic changes linked to two different syndromic forms of autism enhance reinforcement learning in adolescent male but not female mice

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Autism Spectrum Disorder (ASD) is characterized by restricted and repetitive behaviors social differences, both of which may manifest, in part, from underlying differences corticostriatal circuits reinforcement learning. Here, we investigated learning mice with mutations either Tsc2 or Shank3 , high-confidence ASD risk genes associated major syndromic forms ASD. Using an odor-based two-alternative forced choice (2AFC) task, tested adolescent sexes found male Shank3B heterozygote (Het) showed enhanced performance compared to their wild type (WT) siblings. No gain function was observed females. a novel (RL) based computational model infer rate as well policy-level task engagement disengagement, that the males driven positive Het mice. The absent when were trained probabilistic reward schedule. These findings two mouse models reveal convergent phenotype shows similar sensitivity sex environmental uncertainty. data can inform our understanding strengths challenges autism, while providing further evidence experience uncertainty modulate autism-related phenotypes. Reinforcement foundational form widely used behavioral interventions for autism. measured carrying genetic linked different We siblings, females no differences. This longer introduced into schedule correct choices. support diverse changes interact generate common phenotypes Our idea autism produce function.

Язык: Английский

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Synaptic architecture of a memory engram in the mouse hippocampus

Science, Год журнала: 2025, Номер 387(6740)

Опубликована: Март 20, 2025

Memory engrams are formed through experience-dependent plasticity of neural circuits, but their detailed architectures remain unresolved. Using three-dimensional electron microscopy, we performed nanoscale reconstructions the hippocampal CA3-CA1 pathway after chemogenetic labeling cellular ensembles recruited during associative learning. Neurons with a remote history activity coinciding memory acquisition showed no strong preference for wiring each other. Instead, connectomes expanded multisynaptic boutons independently coactivation state postsynaptic partners. The rewiring representing an initial engram was accompanied by input-specific, spatially restricted upscaling individual synapses, as well remodeling mitochondria, smooth endoplasmic reticulum, and interactions astrocytes. Our findings elucidate physical hallmarks long-term offer structural basis flexibility information coding.

Язык: Английский

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The dendritic engram

Frontiers in Behavioral Neuroscience, Год журнала: 2023, Номер 17

Опубликована: Июль 27, 2023

Accumulating evidence from a wide range of studies, including behavioral, cellular, molecular and computational findings, support key role dendrites in the encoding recall new memories. Dendrites can integrate synaptic inputs non-linear ways, provide substrate for local protein synthesis facilitate orchestration signaling pathways that regulate plasticity. These capabilities allow them to act as second layer computation within neuron serve fundamental unit As such, are integral parts memory engram, namely physical representation memories brain increasingly studied during learning tasks. Here, we review experimental studies novel, dendritic view engram is centered on branches elementary units. We highlight potential implications engrams field discuss future research directions.

Язык: Английский

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Early excitatory-inhibitory cortical modifications following skill learning are associated with motor memory consolidation and plasticity overnight

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Янв. 30, 2024

Abstract Consolidation of motor memories is vital to offline enhancement new skills and involves short longer-term processes following learning. While emerging evidence link glutamate GABA dynamics in the primary cortex (M1) online skill practice, its relationship with consolidation humans unclear. Using two-day repeated measures behavioral multimodal neuroimaging data before sequence learning, we show that short-term glutamatergic GABAergic responses M1 within minutes after learning were associated learning-induced functional, structural, modifications overnight. Furthermore, Glutamatergic differentially different facets memory consolidation. Our results point unique distinct roles Glutamate human brain across timescales mechanistic levels, tying changes on neurochemical level overnight macroscale structure, function, behavior.

Язык: Английский

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Information flow between motor cortex and striatum reverses during skill learning

Current Biology, Год журнала: 2024, Номер 34(9), С. 1831 - 1843.e7

Опубликована: Апрель 10, 2024

The coordination of neural activity across brain areas during a specific behavior is often interpreted as communication involved in controlling the behavior. However, whether information relevant to actually transferred between untested. Here, we used information-theoretic tools quantify how motor cortex and striatum encode exchange behaviorally about reach-to-grasp movement features skill learning rats. We found temporal shift encoding learning, well reversal primary direction flow, from cortex-to-striatum naive movements striatum-to-cortex skilled movements. Standard analytical methods that evolution overall learning-such changes signal amplitude or areas-failed capture these dynamics. Using standard methods, instead consistent coactivation signals production bidirectional increase propagation learning. Our results show achieved through transformation routed cortical subcortical isolating components informative critical uncover directional interactions within coactive coordinated network.

Язык: Английский

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A fast and responsive voltage indicator with enhanced sensitivity for unitary synaptic events

Neuron, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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A nociceptive amygdala-striatal pathway for chronic pain aversion

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 13, 2024

The basolateral amygdala (BLA) is essential for assigning positive or negative valence to sensory stimuli. Noxious stimuli that cause pain are encoded by an ensemble of

Язык: Английский

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Neuromorphic Optical Data Storage Enabled by Nanophotonics: A Perspective

ACS Photonics, Год журнала: 2024, Номер 11(3), С. 874 - 891

Опубликована: Март 5, 2024

The development of cloud computing and artificial intelligence technology has increased data storage demands, causing an urgency to progress nanophotonics-enabled optical storage. Inspiration can be taken from the working principles brain's memory that high capacity parallelism, integration between processing with self-learning ability, low-power consumption. correlation emerging neuroscience concept cell engrams as basic units nanophotonics techniques materials aid neuromorphic enabled by toward higher throughput lower energy In this perspective, we explore feasibility a counterpart biology emulating based on We overview materials, well challenges opportunities such implementation for future nanophotonics.

Язык: Английский

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