Context-specific Polycomb mechanisms in development

Nature Reviews Genetics, Год журнала: 2022, Номер 23(11), С. 680 - 695

Опубликована: Июнь 9, 2022

Язык: Английский

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Dynamic chromatin regulatory programs during embryogenesis of hexaploid wheat

Genome biology, Год журнала: 2023, Номер 24(1)

Опубликована: Янв. 13, 2023

Abstract Background Plant and animal embryogenesis have conserved distinct features. Cell fate transitions occur during in both plants animals. The epigenomic processes regulating plant remain largely elusive. Results Here, we elucidate chromatin transcriptomic dynamics of the most cultivated crop, hexaploid wheat. Time-series analysis reveals stage-specific proximal–distal accessibility concordant with transcriptome changes. Following fertilization, remodeling kinetics H3K4me3, H3K27ac, H3K27me3 differ from that mammals, highlighting considerable species-specific zygotic genome activation. Polycomb repressive complex 2 (PRC2)-mediated deposition is important for embryo establishment. Later H3K27me3, undergo dramatic to establish a permissive environment facilitating access transcription factors cis -elements patterning. Embryonic maturation characterized by increasing decreasing accessibility, which likely participates restricting totipotency while preventing extensive organogenesis. Finally, signatures are correlated biased expression among homeolog triads divergent after polyploidization, revealing an contributor subgenome diversification allohexaploid genome. Conclusions Collectively, present invaluable resource comparative mechanistic regulation crop embryogenesis.

Язык: Английский

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Epigenetic regulation of early human embryo development

Cell stem cell, Год журнала: 2023, Номер 30(12), С. 1569 - 1584

Опубликована: Окт. 18, 2023

Studies of mammalian development have advanced our understanding the genetic, epigenetic, and cellular processes that orchestrate embryogenesis uncovered new insights into unique aspects human embryogenesis. Recent studies now produced first epigenetic maps early embryogenesis, stimulating ideas about reprogramming, cell fate control, potential mechanisms underpinning developmental plasticity in embryos. In this review, we discuss these regulation importance for safeguarding development. We also highlight unanswered questions key challenges remain to be addressed.

Язык: Английский

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Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition

Nature Structural & Molecular Biology, Год журнала: 2023, Номер 30(2), С. 200 - 215

Опубликована: Янв. 16, 2023

Abstract Poly(A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in the oocyte-to-embryo transition (OET). Nothing known about poly(A) tail dynamics during human OET. Here, we show that length and internal non-A residues are highly dynamic OET, using poly(A)-inclusive RNA isoform sequencing (PAIso-seq). Unexpectedly, undergo global remodeling: after deadenylation or partial degradation into 3ʹ-UTRs, they re-polyadenylated to produce polyadenylated intermediates, coinciding with massive incorporation residues, particularly long consecutive U newly synthesized tails. Moreover, TUT4 TUT7 contribute these BTG4-mediated produces substrates for mRNA re-polyadenylation, TENT4A TENT4B incorporate G residues. The remodeling further confirmed PAIso-seq2. Importantly, essential first cleavage embryos. Together, findings broaden our understanding

Язык: Английский

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Capturing totipotency in human cells through spliceosomal repression

Cell, Год журнала: 2024, Номер 187(13), С. 3284 - 3302.e23

Опубликована: Июнь 1, 2024

Язык: Английский

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Roles of H3K4 methylation in biology and disease

Trends in Cell Biology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 1, 2024

Epigenetic modifications, including posttranslational modifications of histones, are closely linked to transcriptional regulation. Trimethylated H3 lysine 4 (H3K4me3) is one the most studied histone owing its enrichment at start sites transcription and association with gene expression processes determining cell fate, development, disease. In this review, we focus on recent studies that have yielded insights into how levels patterns H3K4me3 regulated, contributes regulation specific phases such as RNA polymerase II initiation, pause–release, heterogeneity, consistency. The conclusion from these by itself regulates precise essential for normal development preventing

Язык: Английский

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Comparative proteomic landscapes elucidate human preimplantation development and failure

Cell, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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The subcortical maternal complex safeguards mouse oocyte-to-embryo transition by preventing nuclear entry of SPIN1

Nature Structural & Molecular Biology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 17, 2025

Язык: Английский

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Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos

Molecular Cell, Год журнала: 2019, Номер 77(4), С. 825 - 839.e7

Опубликована: Дек. 12, 2019

Язык: Английский

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Allelic H3K27me3 to allelic DNA methylation switch maintains noncanonical imprinting in extraembryonic cells

Science Advances, Год журнала: 2019, Номер 5(12)

Опубликована: Дек. 6, 2019

Maternal H3K27me3–mediated imprinting switches to allelic DNA methylation maintain imprinted expression in extraembryonic cells.

Язык: Английский

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